A novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Cell Science

• Publication date

  2008-07-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1242/jcs.024018PMID 18559893PMCID PMC2902979
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Discovery and biochemical characterization of selective ATP competitive inhibitors of the human mitotic kinesin KSP.

  2008cited by this paper
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  2004cited by this paper
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• Modeling and mechanical perturbations reveal how spatially regulated anchorage gives rise to spatially distinct mechanics across the mammalian spindle

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• A gelation transition enables the self-organization of bipolar metaphase spindles

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• Microtubule-sliding modules based on kinesins EG5 and PRC1-dependent KIF4A drive human spindle elongation

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• Chemical tools for dissecting cell division

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• Various effects of two types of kinesin-5 inhibitors on mitosis and cell proliferation.

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• Mechanism of microtubule-trapped human kinesin-5 inhibition revealed using cryo-EM

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• Centrosomal and Non-centrosomal Functions Emerged through Eliminating Centrosomes

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• Active forces shape the metaphase spindle through a mechanical instability

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• Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy

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  2017influential citation
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• Loss‐of‐Function Mutations in KIF15 Underlying a Braddock–Carey Genocopy

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