RNA editing modulates the binding of drugs and highly unsaturated fatty acids to the open pore of Kv potassium channels

No abstract is available for this paper.

• Publication year

  2010

• Venue

  EMBO Journal

• Publication date

  2010-07-07

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/emboj.2010.88PMID 20461057PMCID PMC2905254
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Polyunsaturated Fatty Acid Modulation of Voltage-Gated Ion Channels

  2008cited by this paper
• Lipid Bilayer–mediated Regulation of Ion Channel Function by Amphiphilic Drugs

  2008cited by this paper
• Structural determinants of Kvβ1.3‐induced channel inactivation: a hairpin modulated by PIP2

  2008cited by this paper
• Endocannabinoid signaling as a synaptic circuit breaker in neurological disease

  2008cited by this paper
• Arachidonic acid and ion channels: an update

  2008cited by this paper
• Characterization of Five RNA Editing Sites in Shab Potassium Channels

  2008cited by this paper
• Probing the Cavity of the Slow Inactivated Conformation of Shaker Potassium Channels

  2007cited by this paper
• Phospholipases and fatty acid signalling in exocytosis

  2007cited by this paper
• Short- and long-term plasticity of the endocannabinoid system in neuropsychiatric and neurological disorders.

  2007cited by this paper
• Biosynthetic Pathways of the Endocannabinoid Anandamide

  2007cited by this paper
• Phospholipase A2-generated lipid mediators in the brain: the good, the bad, and the ugly.

  2006cited by this paper
• Phospholipase A₂-Generated Lipid Mediators in the Brain: The Good, the Bad, and the Ugly

  2006cited by this paper
• Binding Site of a Novel Kv1.5 Blocker: A “Foot in the Door” against Atrial Fibrillation

  2006cited by this paper
• Block of neural Kv1.1 potassium channels for neuroinflammatory disease therapy

  2006cited by this paper
• Structural Basis for Competition between Drug Binding and Kvβ1.3 Accessory Subunit-Induced N-Type Inactivation of Kv1.5 Channels

  2005cited by this paper
• Molecular Basis for Kv1.5 Channel Block

  2004cited by this paper
• Localization of voltage-gated ion channels in mammalian brain.

  2004cited by this paper
• Control of human potassium channel inactivation by editing of a small mRNA hairpin

  2004cited by this paper
• Functional Conversion Between A-Type and Delayed Rectifier K+ Channels by Membrane Lipids

  2004cited by this paper
• Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators.

  2004cited by this paper
• Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model.

  2004cited by this paper
• Novel Docosanoids Inhibit Brain Ischemia-Reperfusion-mediated Leukocyte Infiltration and Pro-inflammatory Gene Expression*

  2003cited by this paper
• Nervous System Targets of RNA Editing Identified by Comparative Genomics

  2003cited by this paper
• Phospholipase A2 regulation of arachidonic acid mobilization

  2002cited by this paper
• Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors

  2001cited by this paper
• Arachidonic acid as a bioactive molecule.

  2001cited by this paper
• Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin‐like activity

  2000cited by this paper
• Subunit Composition of Brain Voltage-gated Potassium Channels Determined by Hongotoxin-1, a Novel Peptide Derived fromCentruroides limbatus Venom*

  1998cited by this paper
• The moving parts of voltage-gated ion channels

  1998cited by this paper
• Quantitative assessment of sustained‐release 4‐aminopyridine for symptomatic treatment of multiple sclerosis

  1997cited by this paper
• RNA editing generates a diverse array of transcripts encoding squid Kv2 K+ channels with altered functional properties.

  1997cited by this paper
• External blockade of the major cardiac delayed-rectifier K+ channel (Kv1.5) by polyunsaturated fatty acids.

  1994cited by this paper
• Inactivation properties of voltage-gated K+ channels altered by presence of β-subunit

  1994cited by this paper
• Different Types of Potassium Outward Current in Relay Neurons Acutely Isolated from the Rat Lateral Geniculate Nucleus

  1992cited by this paper
• Tetraethylammonium blockade distinguishes two inactivation mechanisms in voltage-activated K+ channels.

  1991cited by this paper
• Gating mechanism of a cloned potassium channel expressed in frog oocytes and mammalian cells.

  1990cited by this paper
• Potassium channels expressed from rat brain cDNA have delayed rectifier properties

  1988cited by this paper
• Sodium and calcium channels in bovine chromaffin cells

  1982cited by this paper
• Modulation of the excitatory synaptic response by fast transient K+ current in snail neurones.

  1973cited by this paper
• Voltage clamp studies of a transient outward membrane current in gastropod neural somata

  1971cited by this paper
• Interaction of Tetraethylammonium Ion Derivatives with the Potassium Channels of Giant Axons

  1971cited by this paper

• Advances in Detection Methods for A‐to‐I RNA Editing

  2025cites this paper
• Characterization of Kv1.2-mediated outward current in TRIP8b-deficient mice

  2023cites this paper
• Handbook of Ion Channels

  2023cites this paper
• Recommendations for detection, validation, and evaluation of RNA editing events in cardiovascular and neurological/neurodegenerative diseases

  2023cites this paper
• RNA epitranscriptomics dysregulation: A major determinant for significantly increased risk of ASD pathogenesis

  2023cites this paper
• RNA editing of ion channels and receptors in physiology and neurological disorders.

  2022cites this paper
• Adenosine-to-inosine RNA editing in neurological development and disease

  2021cites this paper
• Conservation of A-to-I RNA editing in bowhead whale and pig

  2021cites this paper
• Endocannabinoids Tune Intrinsic Excitability in O-LM Interneurons by Direct Modulation of Postsynaptic Kv7 Channels

  2021cites this paper
• Subtype specific responses in hKv7.4 and hKv7.5 channels to polyunsaturated fatty acids

  2021cites this paper
• Long-lasting reduction of intrinsic excitability in O-LM interneurons is mediated by endocannabinoid-dependent up-regulation of Kv7 channels

  2021cites this paper
• Functional Differences Between Two Kv1.1 RNA Editing Isoforms: a Comparative Study on Neuronal Overexpression in Mouse Prefrontal Cortex

  2021cites this paper
• Mutations underlying Episodic Ataxia type-1 antagonize Kv1.1 RNA editing

  2017cites this paper
• Actions and Mechanisms of Polyunsaturated Fatty Acids on Voltage-Gated Ion Channels

  2017cites this paper
• Modulation of thalamocortical oscillations by TRIP8b, an auxiliary subunit for HCN channels

  2017cites this paper
• The Structural Dynamics of Soluble and Membrane Proteins Explored through Molecular Simulations

  2016cites this paper
• Interaction of lipids with the neurotensin receptor 1.

  2016cites this paper
• The Molecular Basis of Polyunsaturated Fatty Acid Interactions with the Shaker Voltage-Gated Potassium Channel

  2016cites this paper
• Alternative Splicing and RNA Editing of Voltage-Gated Ion Channels: Implications in Health and Disease

  2016cites this paper
• Regulation of Ion Channel and Transporter Function Through RNA Editing.

  2015cites this paper
• Endocannabinoids and Their Pharmacological Actions.

  2015cites this paper
• Kv1.5 blockers preferentially inhibit TASK-1 channels: TASK-1 as a target against atrial fibrillation and obstructive sleep apnea?

  2014cites this paper
• Microsoft Word-Streit et al. Kv1 Editing trafficking 2014-08-05 ohne.docx

  2014influential citation
• RNA Editing in the Central Cavity as a Mechanism to Regulate Surface Expression of the Voltage-gated Potassium Channel Kv1.1*

  2014cites this paper
• Homology model and targeted mutagenesis identify critical residues for arachidonic acid inhibition of Kv4 channels

  2013cites this paper
• Q/R site interactions with the M3 helix in GluK2 kainate receptor channels revealed by thermodynamic mutant cycles

  2013influential citation
• The ADAR RNA editing enzyme controls neuronal excitability in Drosophila melanogaster

  2013cites this paper
• K+ channelepsy: progress in the neurobiology of potassium channels and epilepsy

  2013cites this paper
• Putative Impact of RNA Editing on Drug Discovery

  2013cites this paper
• A-to-I RNA editing: effects on proteins key to neural excitability.

  2012cites this paper
• Multiple Binding Sites for Fatty Acids on the Potassium Channel KcsA

  2012cites this paper
• Transcript Diversification in the Nervous System: A to I RNA Editing in CNS Function and Disease Development

  2012cites this paper
• Editing of neurotransmitter receptor and ion channel RNAs in the nervous system.

  2012cites this paper
• Identification of Putative Potassium Channel Homologues in Pathogenic Protozoa

  2012cites this paper
• Mechanism of Electromechanical Coupling in Voltage-Gated Potassium Channels

  2012cites this paper
• Characterizing the Fatty Acid Binding Site in the Cavity of Potassium Channel KcsA

  2012cites this paper
• Polyunsaturated Fatty Acids Modify the Gating of Kv Channels

  2012influential citation
• The intricate relationship between RNA structure, editing, and splicing.

  2012cites this paper
• Biological membranes: the importance of molecular detail.

  2011cites this paper
• RNA editing of Kv1.1 channels may account for reduced ictogenic potential of 4‐aminopyridine in chronic epileptic rats

  2011cites this paper
• Polyunsaturated Fatty Acids Modifying Ion Channel Voltage Gating

  2011cites this paper
• Visualizing adenosine-to-inosine RNA editing in the Drosophila nervous system

  2011cites this paper
• An electrostatic potassium channel opener targeting the final voltage sensor transition

  2011cites this paper
• Editing of human KV1.1 channel mRNAs disrupts binding of the N-terminus tip at the intracellular cavity

  2011cites this paper
• A-type K+ currents in intralaminar thalamocortical relay neurons

  2011cites this paper
• A-to-I RNA editing modulates the pharmacology of neuronal ion channels and receptors

  2011cites this paper
• Structure and molecular recognition of proteins linked to pre-mRNA splicing and transcriptional regulation

  2010cites this paper
• Channels get in an HUFA: RNA editing gets them out of a jam

  2010influential citation