Highly purified lipopolysaccharides from Burkholderia cepacia complex clinical isolates induce inflammatory cytokine responses via TLR4‐mediated MAPK signalling pathways and activation of NFκB

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Cellular Microbiology

• Publication date

  2007-02-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1111/j.1462-5822.2006.00808.xPMID 17002785
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The multifarious, multireplicon Burkholderia cepacia complex

  2005cited by this paper
• Recognition of Staphylococcus aureus-derived peptidoglycan (PGN) but not intact bacteria is mediated by CD14 in microglia.

  2005cited by this paper
• Complete structural characterization of the lipid A fraction of a clinical strain of B. cepacia genomovar I lipopolysaccharide.

  2005cited by this paper
• CD14 is required for MyD88-independent LPS signaling

  2005cited by this paper
• Differential Induction of the Toll-Like Receptor 4-MyD88-Dependent and -Independent Signaling Pathways by Endotoxins

  2005cited by this paper
• Signal transduction by the lipopolysaccharide receptor, Toll‐like receptor‐4

  2004cited by this paper
• Burkholderia cenocepacia lipopolysaccharide, lipid A, and proinflammatory activity.

  2004influential reference
• Burkholderia cepacia complex infection in cystic fibrosis patients: mechanisms of pathogenesis

  2004cited by this paper
• Lipopolysaccharides of Bacteroides fragilis, Chlamydia trachomatis and Pseudomonas aeruginosa signal via toll-like receptor 2.

  2004cited by this paper
• Biosynthesis, transport, and modification of lipid A.

  2004cited by this paper
• Contribution of Burkholderia cenocepacia Flagella to Infectivity and Inflammation

  2004cited by this paper
• Endotoxins: relationships between structure, function, and activity.

  2004cited by this paper
• Lipopolysaccharide of Burkholderia cepacia complex.

  2003cited by this paper
• Unusual Interaction of a Lipopolysaccharide Isolated from Burkholderia cepacia with Polymyxin B

  2003cited by this paper
• Toll-like Receptors 2 and 4 Activate STAT1 Serine Phosphorylation by Distinct Mechanisms in Macrophages*

  2003influential reference
• Burkholderia cepacia–Induced IL-8 Gene Expression in an Alveolar Epithelial Cell Line: Signaling Through CD14 and Mitogen-Activated Protein Kinase

  2003cited by this paper
• Burkholderia cepacia complex infection in patients with cystic fibrosis: laboratory investigations, epidemiology and clinical management

  2003cited by this paper
• Human Toll-like receptor 4 recognizes host-specific LPS modifications

  2002cited by this paper
• CFTR is a pattern recognition molecule that extracts Pseudomonas aeruginosa LPS from the outer membrane into epithelial cells and activates NF-κB translocation

  2002influential reference
• Of mice and men: species variations of Toll-like receptor expression.

  2002cited by this paper
• MAP kinase activation in macrophages

  2001cited by this paper
• LPS induction of gene expression in human monocytes.

  2001influential reference
• Lipopolysaccharide of Burkholderia cepacia and Its Unique Character To Stimulate Murine Macrophages with Relative Lack of Interleukin-1β-Inducing Ability

  2001cited by this paper
• Disproportionate distribution of Burkholderia cepacia complex species and transmissibility markers in cystic fibrosis.

  2001influential reference
• Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism

  2001cited by this paper
• Lipopolysaccharide Is in Close Proximity to Each of the Proteins in Its Membrane Receptor Complex

  2001cited by this paper
• Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes1

  2001cited by this paper
• Burkholderia cepacia complex genomovars and pulmonary transplantation outcomes in patients with cystic fibrosis.

  2001cited by this paper
• Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

  2000cited by this paper
• Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.

  2000cited by this paper
• Tlr4: central component of the sole mammalian LPS sensor.

  2000cited by this paper
• DNA-Based Diagnostic Approaches for Identification of Burkholderia cepacia Complex, Burkholderia vietnamiensis, Burkholderia multivorans,Burkholderia stabilis, and Burkholderia cepacia Genomovars I and III

  2000cited by this paper
• Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa.

  1999cited by this paper
• An intracellular signaling pathway linking lipopolysaccharide stimulation to cellular responses of the human neutrophil: the p38 MAP kinase cascade and its functional significance.

  1999influential reference
• Lipopolysaccharide (LPS) from Burkholderia cepacia Is More Active than LPS from Pseudomonas aeruginosa and Stenotrophomonas maltophilia in Stimulating Tumor Necrosis Factor Alpha from Human Monocytes

  1999cited by this paper
• A Melanin Pigment Purified from an Epidemic Strain of Burkholderia cepacia Attenuates Monocyte Respiratory Burst Activity by Scavenging Superoxide Anion

  1999cited by this paper
• BURKHOLDERIA CEPACIA: Management Issues and New Insights

  1998cited by this paper
• Human Toll-like Receptor 2 Confers Responsiveness to Bacterial Lipopolysaccharide

  1998influential reference
• Cross infection between cystic fibrosis patients colonised with Burkholderia cepacia

  1998cited by this paper
• Priming of neutrophil respiratory burst activity by lipopolysaccharide from Burkholderia cepacia

  1997cited by this paper
• Burkholderia cepacia: medical, taxonomic and ecological issues.

  1996influential reference
• Outcome for patients colonised with Burkholderia cepacia in a Birmingham adult cystic fibrosis clinic and the end of an epidemic.

  1996cited by this paper
• Epidemiology of Burkholderia cepacia infection in patients with cystic fibrosis: analysis by randomly amplified polymorphic DNA fingerprinting

  1996cited by this paper
• Characterisation of Burkholderia cepacia from cystic fibrosis patients living in Wales by PCR ribotyping.

  1995cited by this paper
• Biological activity of Burkholderia (Pseudomonas) cepacia lipopolysaccharide.

  1995influential reference
• Effects of oxidants and antioxidants on nuclear factor kappa B activation in three different cell lines: evidence against a universal hypothesis involving oxygen radicals.

  1995influential reference
• Distinct patterns of differentiation induced in the monocytic cell line Mono Mac 6

  1994cited by this paper
• Pseudomonas cepacia infection in cystic fibrosis: an emerging problem.

  1984cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976influential reference

• Burkholderia cepacia in cystic fibrosis children and adolescents: overall survival and immune alterations

  2024cites this paper
• Advances in Phage Therapy: Targeting the Burkholderia cepacia Complex

  2021cites this paper
• Outer membrane vesicles produced by Burkholderia cepacia cultured with subinhibitory concentrations of ceftazidime enhance pro-inflammatory responses

  2020cites this paper
• TLRs between Dendritic Cells Extracellular Vesicles with Exosome-like Features Transfer

  2019influential citation
• Evaluation of the proinflammatory effects of contaminated bathing water

  2019cites this paper
• Parkin in early stage LPS-stimulated BV-2 cells regulates pro-inflammatory response and mitochondrial quality via mitophagy.

  2019cites this paper
• Extracellular Vesicles with Exosome-like Features Transfer TLRs between Dendritic Cells

  2019influential citation
• Intracellular survival and innate immune evasion of Burkholderia cepacia: Improved understanding of quorum sensing‐controlled virulence factors, biofilm, and inhibitors

  2019cites this paper
• Study on the anti-endotoxin effect of sinomenine using an Agilent genome array

  2018cites this paper
• A putative lateral flagella of the cystic fibrosis pathogen Burkholderia dolosa regulates swimming motility and host cytokine production

  2018cites this paper
• The LpxL acyltransferase is required for normal growth and penta‐acylation of lipid A in Burkholderia cenocepacia

  2017cites this paper
• Immune Recognition of the Epidemic Cystic Fibrosis Pathogen Burkholderia dolosa

  2017cites this paper
• Evaluation of recombinant factor C assay for the detection of divergent lipopolysaccharide structural species and comparison with Limulus amebocyte lysate‐based assays and a human monocyte activity assay

  2017cites this paper
• Propofol regulates the expression of TLR4 through miR‑21 in human umbilical vein endothelial cells.

  2017cites this paper
• PM2.5‐induced lung inflammation in mice: Differences of inflammatory response in macrophages and type II alveolar cells

  2017cites this paper
• Lactoferrin and Cystic Fibrosis Airway Infection

  2015cites this paper
• Activation of Human Toll-like Receptor 4 (TLR4)·Myeloid Differentiation Factor 2 (MD-2) by Hypoacylated Lipopolysaccharide from a Clinical Isolate of Burkholderia cenocepacia*

  2015cites this paper
• Assay Development for Image-Based Quantification of Intracellular Bacterial Replication and Analysis of the Innate Immune Response to Infection

  2015cites this paper
• Activation of human TLR4/MD-2 by hypoacylated lipopolysaccharide from a clinical isolate of Burkholderia cenocepacia Activation of human TLR4/MD-2 by hypoacylated from a clinical isolate

  2015cites this paper
• Activation of Human Toll-like Receptor 4 (TLR4)center dot Myeloid Differentiation Factor 2 (MD-2) by Hypoacylated Lipopolysaccharide from a Clinical Isolate of Burkholderia cenocepacia

  2015cites this paper
• The role of LPCAT in regulating cellular inflammatory responses to toll-like receptor ligands

  2014cites this paper
• Lipopolysaccharide in marine bathing water; a potential real-time biomarker of bacterial contamination and relevance to human health

  2014cites this paper
• Inhibition of co-colonizing cystic fibrosis-associated pathogens by Pseudomonas aeruginosa and Burkholderia multivorans.

  2014cites this paper
• Adhesins from the human pathogen Burkholderia cenocepacia

  2014cites this paper
• UNIVERSIDADE DE LISBOA FACULDADE DE CIÊNCIAS DEPARTAMENTO DE BIOLOGIA ANIMAL Functional characterization of virulence-associated Trimeric Autotransporter Adhesins from the human pathogen Burkholderia cenocepacia

  2014cites this paper
• Unraveling the Interaction between the LPS O‐Antigen of Burkholderia anthina and the 5D8 Monoclonal Antibody by Using a Multidisciplinary Chemical Approach, with Synthesis, NMR, and Molecular Modeling Methods

  2013cites this paper
• Involvement of Toll-like receptor 4 and Fc receptors gamma in human neutrophil priming by endotoxins from Escherichia coli

  2013cites this paper
• Experimental and bioinformatics approaches to identify potential targets and develop novel strategies to fight infections caused by multiresistant Burkholderia cepacia complex bacteria

  2013cites this paper
• Development of a multicellular co-culture model of normal and cystic fibrosis human airways in vitro

  2012cites this paper
• Persistence of Burkholderia pseudomallei, B. multivorans and B. cenocepacia : differential analysis by proteomics and activation of phosphoinositide-3 kinase

  2012influential citation
• Activation of the Pyrin Inflammasome by Intracellular Burkholderia cenocepacia

  2012cites this paper
• Functions of Burkholderia virulence factors: input from proteomics and DNA microarray analyses

  2012cites this paper
• Host Evasion by Burkholderia cenocepacia

  2012cites this paper
• Mechanisms of Altered Cholesterol Metabolism in Cystic Fibrosis

  2011cites this paper
• The intracellular behaviour of Burkholderia cenocepacia in murine macrophages

  2011cites this paper
• Three-dimensional spheroid cultures of A549 and HepG2 cells exhibit different lipopolysaccharide (LPS) receptor expression and LPS-induced cytokine response compared with monolayer cultures

  2011cites this paper
• TLR4 is involved in mediating fatal murine pneumonia due to Burkholderia cenocepacia

  2011cites this paper
• Evaluation of inflammatory effects of airborne endotoxin emitted from composting sources

  2011cites this paper
• Disparate Regulation of LPS-Induced MAPK Signaling and IL-12p40 Expression Between Different Myeloid Cell Types with and without HIV Infection

  2010cites this paper
• Macrophage responses to CF pathogens: JNK MAP kinase signaling by Burkholderia cepacia complex lipopolysaccharide.

  2010influential citation
• Inflammation in Achromobacter xylosoxidans infected cystic fibrosis patients.

  2010cites this paper
• Stenotrophomonas maltophilia and Burkholderia cepacia Complex

  2010cites this paper
• A Decade of Burkholderia cenocepacia Virulence Determinant Research

  2010cites this paper
• Surfactant lipids regulate LPS-induced interleukin-8 production in A549 lung epithelial cells by inhibiting translocation of TLR4 into lipid raft domains

  2010cites this paper
• Inflammation in chronic granulomatous disease and modulation of human dendritic cell functions by Burkholderia cenocepacia and Burkholderia multivorans

  2009cites this paper
• Burkholderia cepacia complex: epithelial cell-pathogen confrontations and potential for therapeutic intervention.

  2009cites this paper
• Study on the antiendotoxin action of Pulsatillae Decoction using an Affymetrix rat genome array.

  2009cites this paper
• A PTP4A3 Peptide PIMAP39 Modulates TNF-Alpha Levels and Endotoxic Shock

  2009cites this paper
• Gut-derived endotoxin translocation is the main aggravating mechanism of acute severe pancreatitis☆

  2009cites this paper
• Regulation of ornibactin synthesis and utilisationin Burkholderia cenocepacia

  2008cites this paper
• Review: Chemical and biological features of Burkholderia cepacia complex lipopolysaccharides

  2008cites this paper
• TLR 5, but neither TLR2 nor TLR4, is involved in lung epithelial cell response to Burkholderia cenocepacia.

  2008cites this paper
• Differential modulation of innate immune cell functions by the Burkholderia cepacia complex: Burkholderia cenocepacia but not Burkholderia multivorans disrupts maturation and induces necrosis in human dendritic cells

  2008cites this paper
• The structure and proinflammatory activity of the lipopolysaccharide from Burkholderia multivorans and the differences between clonal strains colonizing pre and posttransplanted lungs.

  2008cites this paper
• Lysophospholipid metabolism facilitates Toll‐like receptor 4 membrane translocation to regulate the inflammatory response

  2008cites this paper
• Burkholderia mallei expresses a unique lipopolysaccharide mixture that is a potent activator of human Toll-like receptor 4 complexes

  2007cites this paper