Neuroprotective effect of N-acetylcysteine in the development of diabetic encephalopathy in streptozotocin-induced diabetes

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Metabolic brain disease

• Publication date

  2008-09-19

• Fields of study

  Medicine

• Identifiers
  DOI 10.1007/s11011-008-9104-7PMID 18802743
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Methods of Enzymatic Analysis

  2019cited by this paper
• Glucose neurotoxicity

  2008cited by this paper
• Vanadium improves brain acetylcholinesterase activity on early stage alloxan-diabetic rats.

  2008cited by this paper
• Antioxidative and anti-inflammatory effects of four cysteine-containing agents in striatum of MPTP-treated mice.

  2007cited by this paper
• N-acetylcysteine attenuates PKCbeta2 overexpression and myocardial hypertrophy in streptozotocin-induced diabetic rats.

  2007influential reference
• Curcumin attenuates diabetic encephalopathy in rats: behavioral and biochemical evidences.

  2007cited by this paper
• Antioxidant N-acetylcysteine restores myocardial Mn-SOD activity and attenuates myocardial dysfunction in diabetic rats.

  2006cited by this paper
• Controlling oxidative stress as a novel molecular approach to protecting the vascular wall in diabetes

  2006cited by this paper
• Risk of dementia in diabetes mellitus: a systematic review.

  2006cited by this paper
• Effect of melatonin and vitamin E on diabetes-induced learning and memory impairment in rats.

  2006cited by this paper
• Brain Imaging in Patients With Diabetes

  2006cited by this paper
• Carbofuran-induced neurochemical and neurobehavioral alterations in rats: attenuation by N-acetylcysteine

  2006influential reference
• N-Benzoyl-D-phenylalanine attenuates brain acetylcholinesterase in neonatal streptozotocin-diabetic rats.

  2006influential reference
• Protective effect of N-acetyl-L-cysteine on amyloid beta-peptide-induced learning and memory deficits in mice.

  2006cited by this paper
• Effects of the Ca2+ antagonist nimodipine on functional deficits in the peripheral and central nervous system of streptozotocin-diabetic rats.

  2005cited by this paper
• Clinical trials update from the American Heart Association meeting: ACORN‐CSD, primary care trial of chronic disease management, PEACE, CREATE, SHIELD, A‐HeFT, GEMINI, vitamin E meta‐analysis, ESCAPE, CARP, and SCD‐HeFT cost‐effectiveness study

  2005cited by this paper
• Insulin, C-peptide, hyperglycemia, and central nervous system complications in diabetes.

  2004cited by this paper
• Administration of N‐acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke

  2004cited by this paper
• Hippocampal synaptic plasticity and glutamate receptor regulation: influences of diabetes mellitus.

  2004cited by this paper
• Preventive effect of antioxidants in MPTP-induced mouse model of Parkinson's disease.

  2004cited by this paper
• Evidence That Glutathione Depletion Is a Mechanism Responsible for the Anti-Inflammatory Effects of Ethyl Pyruvate in Cultured Lipopolysaccharide-Stimulated RAW 264.7 Cells

  2004cited by this paper
• Apoptosis of vasopressinergic hypothalamic neurons in chronic diabetes mellitus.

  2004cited by this paper
• The relationship between type 2 diabetes and cognitive dysfunction: longitudinal studies and their methodological limitations.

  2004cited by this paper
• Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function.

  2004cited by this paper
• Pentose Phosphate Pathway, Glutathione-Dependent Enzymes and Antioxidant Defense During Oxidative Stress in Diabetic Rodent Brain and Peripheral Organs: Effects of Stobadine and Vitamin E

  2003cited by this paper
• The antioxidants α‐lipoic acid and N‐acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice

  2003cited by this paper
• New insights on oxidative stress and diabetic complications may lead to a "causal" antioxidant therapy.

  2003cited by this paper
• Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics

  2003cited by this paper
• Angiotensin converting enzyme inhibition partially prevents deficits in water maze performance, hippocampal synaptic plasticity and cerebral blood flow in streptozotocin-diabetic rats

  2003cited by this paper
• N-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: possible role of oxidative stress.

  2003cited by this paper
• Dehydroepiandrosterone modulates nuclear factor-kappaB activation in hippocampus of diabetic rats.

  2002cited by this paper
• Does insulin dysfunction play a role in Alzheimer's disease?

  2002cited by this paper
• Comparative analysis of the protective effects of melatonin and vitamin E on streptozocin‐induced diabetes mellitus

  2002cited by this paper
• Glucose and reactive oxygen species

  2002cited by this paper
• Diabetes, the brain, and behavior: is there a biological mechanism underlying the association between diabetes and depression?

  2002cited by this paper
• N-acetylcysteine reduced the effect of ethanol on antioxidant system in rat plasma and brain tissue.

  2002cited by this paper
• Hippocampal neuronal apoptosis in type 1 diabetes.

  2002cited by this paper
• Ageing and diabetes: implications for brain function.

  2002cited by this paper
• G6PD deficiency: its role in the high prevalence of hypertension and diabetes mellitus.

  2001cited by this paper
• High glucose inhibits renal proximal tubule cell proliferation and involves PKC, oxidative stress, and TGF-beta 1.

  2001cited by this paper
• Cardiovascular risk factors and cognitive decline in middle-aged adults

  2001cited by this paper
• Diabetes-induced changes in calcium homeostasis and the effects of calcium channel blockers in rat and mice nociceptive neurons

  2001cited by this paper
• The potential mechanism of the diabetogenic action of streptozotocin: inhibition of pancreatic beta-cell O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase.

  2001cited by this paper
• Hyperglycemia in diabetic rats reduces the glutathione content in the aortic tissue.

  2001cited by this paper
• Effects of L-phenylalanine on acetylcholinesterase and Na(+), K(+)-ATPase activities in adult and aged rat brain.

  2001cited by this paper
• Chronic exposure of human mesangial cells to high glucose environments activates the p38 MAPK pathway.

  2001cited by this paper
• Oxidative derangement in rat synaptosomes induced by hyperglycaemia: restorative effect of dehydroepiandrosterone treatment.

  2000cited by this paper
• The effect of topical insulin on the release of excitotoxic and other amino acids from the rat cerebral cortex during streptozotocin-induced hyperglycemic ischemia.

  2000cited by this paper
• Dehydroepiandrosterone prevents oxidative injury induced by transient ischemia/reperfusion in the brain of diabetic rats.

  2000cited by this paper
• N-Acetylcysteine delays age-associated memory impairment in mice: role in synaptic mitochondria.

  2000cited by this paper
• Cognition and synaptic plasticity in diabetes mellitus.

  2000cited by this paper
• Detection of Cell Death of Cultured Mouse Mesangial Cells Induced by Oxidized Low-Density Lipoprotein

  1999cited by this paper
• Change in the lipid profile, lipogenic and related enzymes in the livers of experimental diabetic rats: effect of insulin and vanadate.

  1999cited by this paper
• Pentoxifylline and N-acetylcysteine in hepatic ischemia/reperfusion injury.

  1998cited by this paper
• Oxidant-mediated repression of mitochondrial transcription in diabetic rats.

  1997cited by this paper
• N-acetylcysteine does not protect against type II cell injury after prolonged exposure to hyperoxia in rats.

  1997cited by this paper
• Antioxidant inhibition of protein kinase C-signaled increases in transforming growth factor-beta in mesangial cells.

  1997cited by this paper
• The Roles of Oxidative Stress and Antioxidant Treatment in Experimental Diabetic Neuropathy

  1997cited by this paper
• Prostaglandin E2 increases 7-pS Cl- channel density in the apical membrane of A6 distal nephron cells.

  1997cited by this paper
• Interaction of exercise and ethanol on antioxidant enzymes in brain regions of the rat.

  1996cited by this paper
• Alterations in tissue glutathione antioxidant system in streptozotocin-induced diabetic rats

  1996influential reference
• Aldose reductase and sorbitol dehydrogenase activities in diabetic brain: in vivo kinetic studies using 19F 3‐FDG NMR in rats

  1996cited by this paper
• Mesostriatal dopamine markers in aged Long-Evans rats with sensorimotor impairment.

  1995cited by this paper
• Lipoperoxidative damage on lead exposure in rat brain and its implications on membrane bound enzymes.

  1994cited by this paper
• The importance of sample preparation and storage in glutathione analysis.

  1993cited by this paper
• Glycation of Brain Actin in Experimental Diabetes

  1993cited by this paper
• N‐acetyl‐l‐cysteine

  1993cited by this paper
• Reactive Oxygen Species and the Central Nervous System

  1992influential reference
• Utility of an elevated plus-maze for dissociation of amnesic and behavioral effects of drugs in mice.

  1991cited by this paper
• Hippocampal and prefrontal cortex contributions to learning and memory: analysis of lesion and aging effects on maze learning in rats.

  1990cited by this paper
• Regional Brain Glucose Metabolism and Blood Flow in Streptozocin-Induced Diabetic Rats

  1990cited by this paper
• The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid.

  1989cited by this paper
• Glutathione transferases from human liver.

  1985cited by this paper
• [59] Glutathione reductase

  1985cited by this paper
• Glutathione reductase.

  1985cited by this paper
• [62] Glutathione transferases from human liver

  1985cited by this paper
• Catalase in vitro.

  1984cited by this paper
• Assays of glutathione peroxidase.

  1984cited by this paper
• Changes of glutathione and protein bound SH-groups concentration in rat adrenals under acute and repeated stress.

  1982cited by this paper
• Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.

  1979cited by this paper
• Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase.

  1978cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper
• Cholinesterases

  1948cited by this paper

• N-acetyl-L-cysteine mitigates diabetes-induced impairments in sciatic nerve

  2025cites this paper
• Fluimucil as a neuroprotective, is there anything new? Bibliometric study from 1996 to 2024

  2025cites this paper
• Comparison of therapeutic effects of N-Acetylcysteine with pregabalin in improving the clinical symptoms of painful diabetic neuropathy: a randomized, double-blind clinical trial

  2024cites this paper
• Neuroprotective Potential of Hygrophila auriculata Targeting Oxidative Stress-Mediated Deficits in Streptozotocin-Induced Sciatic Nerve Injury

  2024cites this paper
• Investigation of the effect of N-acetylcysteine on serum levels of oxidative inflammatory biomarkers in patients with stroke

  2023cites this paper
• Hydrogen sulfide: From a toxic gas to a potential therapy for COVID-19 and inflammatory disorders.

  2023cites this paper
• N-acetylcysteine ameliorates chemotherapy-induced impaired anxiety and depression-like behaviors by regulating inflammation, oxidative and cholinergic status, and BDNF release.

  2023cites this paper
• Synthesis, Characterization and Inhibitor Properties of Benzimidazolium Salts Bearing 4-(methylsulfonyl)benzyl Side Arms

  2022cites this paper
• Hyperoside attenuates neuroinflammation, cognitive impairment and oxidative stress via suppressing TNF-α/NF-κB/caspase-3 signaling in type 2 diabetes rats

  2021cites this paper
• Synthesis, Characterization, and Inhibition Study of Novel Substituted Phenylureido Sulfaguanidine Derivatives as α‐Glycosidase and Cholinesterase Inhibitors

  2021cites this paper
• N-Acetylcysteine Reverses Monocrotophos Exposure-Induced Hepatic Oxidative Damage via Mitigating Apoptosis, Inflammation and Structural Changes in Rats

  2021cites this paper
• N-Acetylcysteine Attenuates Monocrotophos-induced Toxicity by Mitigating Oxidative Stress and Structural Changes in Rat Liver

  2021cites this paper
• N-Acetylcysteine Ameliorates Neurotoxic Effects of Manganese Intoxication in Rats: A Biochemical and Behavioral Study

  2021cites this paper
• Role of Antioxidants in Hypoxia-Induced Learning and Memory Deficit

  2020cites this paper
• Diabetic Encephalopathy Affecting Mitochondria and Axonal Transport Proteins

  2020cites this paper
• Benzenesulfonamide derivatives as potent acetylcholinesterase, α-glycosidase, and glutathione S-transferase inhibitors: biological evaluation and molecular docking studies

  2020influential citation
• Diabetes–Alzheimer's Disease Link: Targeting Mitochondrial Dysfunction and Redox Imbalance

  2020cites this paper
• Neuroscientific Research for Management of Dementia

  2019cites this paper
• Energy Metabolism and Redox State in Brains of Wistar Audiogenic Rats, a Genetic Model of Epilepsy

  2019cites this paper
• Agomelatine pretreatment prevents development of hyperglycemia and hypoinsulinemia in streptozotocin‐induced diabetes in mice

  2018cites this paper
• N-Acetylcysteine supplementation decreased brain lipid and protein oxidations produced by experimental homocysteine thiolactone exposure: Relevance to neurodegeneration.

  2018cites this paper
• Control of macrophage autophagy by miR-384-5p in the development of diabetic encephalopathy.

  2018cites this paper
• Application of N-Acetylcysteine in Neurological Disorders

  2018cites this paper
• The effect of N‐acetylcysteine (NAC) on human cognition – A systematic review

  2017cites this paper
• The Impact of Microbiota-Gut-Brain Axis on Diabetic Cognition Impairment

  2017cites this paper
• Comparative histological study on the effect of ginger versus &agr;-lipoic acid on the cerebellum of a male albino rat model of induced diabetes

  2016cites this paper
• Calycosin ameliorates diabetes-induced cognitive impairments in rats by reducing oxidative stress via the PI3K/Akt/GSK-3β signaling pathway.

  2016cites this paper
• Investigation of the Hypoglycemic and Antioxidant Effects of Lycopene in Chlorpyrifos-Ethyl Treated Diabetic Rats

  2015cites this paper
• Changes in mitochondrial morphology induced by calcium or rotenone in primary astrocytes occur predominantly through ros‐mediated remodeling

  2015cites this paper
• Prolonged hyperglycemia & hyperinsulinemia increases BDNF mRNA expression in the posterior ventromedial hypothalamus and the dorsomedial hypothalamus of fed female rats.

  2015cites this paper
• Asiaticoside attenuates diabetes-induced cognition deficits by regulating PI3K/Akt/NF-κB pathway.

  2015cites this paper
• Inflammatory Macrophages Promotes Development of Diabetic Encephalopathy

  2015cites this paper
• The mature/pro nerve growth factor ratio is decreased in the brain of diabetic rats: Analysis by ELISA methods.

  2015cites this paper
• Avocado Oil Improves Mitochondrial Function and Decreases Oxidative Stress in Brain of Diabetic Rats

  2015cites this paper
• Effect of an Inhibitor of Sphingomyelinases, N-Acetylcysteine, on Cognitive Functions in Old Rats

  2014cites this paper
• Mitochondrial cofactors in experimental Huntington's disease: behavioral, biochemical and histological evaluation.

  2014cites this paper
• Anti-oxidant, anti-inflammatory and anti-cholinergic action of Adhatoda vasica Nees contributes to amelioration of diabetic encephalopathy in rats: Behavioral and biochemical evidences

  2014cites this paper
• Rosmarinic acid prevents lipid peroxidation and increase in acetylcholinesterase activity in brain of streptozotocin‐induced diabetic rats

  2014cites this paper
• Reversal of neurobehavioral and neurochemical alterations in STZ-induced diabetic rats by FeTMPyP, a peroxynitrite decomposition catalyst and 1,5-Isoquinolinediol a poly(ADP-ribose) polymerase inhibitor

  2014cites this paper
• Amelioration of diabetes-induced neurobehavioral and neurochemical changes by melatonin and nicotinamide: implication of oxidative stress-PARP pathway.

  2013cites this paper
• Neuroprotective effect of paeonol on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat.

  2013cites this paper
• The combined effect of metformin and L-cysteine on inflammation, oxidative stress and insulin resistance in streptozotocin-induced type 2 diabetes in rats.

  2013cites this paper
• Luteolin attenuates diabetes-associated cognitive decline in rats.

  2013cites this paper
• Protective effects of N-acetylcysteine on 3, 4-methylenedioxymethamphetamine-induced neurotoxicity in male Sprague–Dawley rats

  2013cites this paper
• Hypothalamic S-Nitrosylation Contributes to the Counter-Regulatory Response Impairment following Recurrent Hypoglycemia

  2013cites this paper
• Myosins Are Differentially Expressed under Oxidative Stress in Chronic Streptozotocin-Induced Diabetic Rat Brains

  2013cites this paper
• Crocin Improved Learning and Memory Impairments in Streptozotocin-Induced Diabetic Rats

  2013influential citation
• Antidiabetic and antiacetylcholinesterase effects of ethyl acetate fraction of Chaenomeles sinensis (Thouin) Koehne fruits in streptozotocin-induced diabetic rats.

  2013cites this paper
• Mapping the brain in type II diabetes: Voxel-based morphometry using DARTEL.

  2012cites this paper
• The Beneficial Effect Of Trifolium Flower Extracts On Paracetamol- Intoxicated Male Rats

  2012cites this paper
• Ginsenoside Re attenuates diabetes-associated cognitive deficits in rats.

  2012cites this paper
• Hyperglycemia Induces the Variations of 11β-Hydroxysteroid Dehydrogenase Type 1 and Peroxisome Proliferator-Activated Receptor-γ Expression in Hippocampus and Hypothalamus of Diabetic Rats

  2012cites this paper
• High-Glucose and S100B Stimulate Glutamate Uptake in C6 Glioma Cells

  2012cites this paper
• Effects of Infantile Repeated Hyperglycemia on Behavioral Alterations in Adult male and female Rats

  2012cites this paper
• Anti-inflammation and antioxidant effect of Cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis, in middle cerebral artery occlusion-induced focal cerebral ischemia in rats

  2012cites this paper
• Protective effect of NAC against malathion-induced oxidative stress in freshly isolated rat hepatocytes.

  2012cites this paper
• N-Acetylcysteine Reverses Mitochondrial Dysfunctions and Behavioral Abnormalities in 3-Nitropropionic Acid-Induced Huntington’s Disease

  2012cites this paper
• Protective effect of N-acetylcysteine supplementation on mitochondrial oxidative stress and mitochondrial enzymes in cerebral cortex of streptozotocin-treated diabetic rats.

  2011cites this paper
• Anti-oxidant treatment in obstructive sleep apnoea syndrome.

  2011cites this paper
• Amelioration of aluminium - intake oxidative stress by some antioxidants in male albino rats

  2011cites this paper
• High Blood Glucose and Damage to Neuronal Tissue

  2011cites this paper
• EFEITO DO TRATAMENTO COM N-ACETILCISTEÍNA SOBRE PARÂMETROS NOCICEPTIVO E DE ESTRESSE OXIDATIVO E NITROSATIVO EM MEDULA ESPINAL DE RATOS COM CONSTRIÇÃO NO NERVO ISQUIÁTICO

  2011cites this paper
• Davunetide (NAP) as a preventative treatment for central nervous system complications in a diabetes rat model

  2011cites this paper
• Emblica officinalis Corrects Functional, Biochemical and Molecular Deficits in Experimental Diabetic Neuropathy by Targeting the Oxido‐nitrosative Stress Mediated Inflammatory Cascade

  2011cites this paper
• Type 1 diabetes mellitus and major depressive disorder: evidence for a biological link

  2011cites this paper
• N‐acetylcysteine inhibits hyperglycemia‐induced oxidative stress and apoptosis markers in diabetic neuropathy

  2010cites this paper
• Diabetes and vascular disease: basic concepts of nitric oxide physiology, endothelial dysfunction, oxidative stress and therapeutic possibilities.

  2010cites this paper
• Repetitive exposures to low-dose X-rays attenuate testicular apoptotic cell death in streptozotocin-induced diabetes rats.

  2010cites this paper
• Micronutrients for the Prevention of Diabetes and Improvement of the Standard Therapy

  2010cites this paper
• Sex differences in neuroactive steroid levels in the nervous system of diabetic and non-diabetic rats.

  2010cites this paper
• Hyperglycemia-induced oxidative-stress, apoptosis, and embryopathy

  2010cites this paper
• Effects of adult-onset streptozotocin-induced diabetes on the rat brain antioxidant status and the activities of acetylcholinesterase, (Na+,K+)- and Mg2+-ATPase: modulation by L-cysteine

  2009cites this paper
• Inflammation in Diabetic Encephalopathy is Prevented by C-Peptide.

  2009cites this paper
• Hyperglycemia-induced alterations in synaptosomal membrane fluidity and activity of membrane bound enzymes: beneficial effect of N-acetylcysteine supplementation.

  2009cites this paper
• N-Acetylcysteine Prevents Mitochondria from Oxidative Injury Induced by Conventional Peritoneal Dialysate in Human Peritoneal Mesothelial Cells

  2009cites this paper