Aurora kinase A gene copy number is associated with the malignant transformation of colorectal adenomas but not with the serrated neoplasia progression.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Human Pathology

• Publication date

  2015-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.humpath.2014.11.016PMID 25596657
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update.

  2013cited by this paper
• The serrated pathway to colorectal carcinoma: current concepts and challenges

  2013influential reference
• Occurrence of Aurora A positive multipolar mitoses in distinct molecular classes of colorectal carcinomas and effect of Aurora A inhibition

  2012cited by this paper
• Causes and consequences of aneuploidy in cancer

  2012cited by this paper
• Serrated Lesions of the Colorectum: Review and Recommendations From an Expert Panel

  2012cited by this paper
• The natural history of colorectal adenomas and early cancer

  2012cited by this paper
• European guidelines for quality assurance in colorectal cancer screening and diagnosis. First Edition – Principles of evidence assessment and methods for reaching recommendations

  2012cited by this paper
• Update on the serrated pathway to colorectal carcinoma.

  2011cited by this paper
• TPX2 and AURKA promote 20q amplicon-driven colorectal adenoma to carcinoma progression

  2011cited by this paper
• Copy number increase of aurora kinase A in colorectal cancers: a correlation with tumor progression.

  2010cited by this paper
• Shared and separate functions of polo-like kinases and aurora kinases in cancer

  2010cited by this paper
• Quality assurance in pathology in colorectal cancer screening and diagnosis—European recommendations

  2010cited by this paper
• Aurora A is differentially expressed and regulated in chromosomal and microsatellite instable sporadic colorectal cancers

  2009influential reference
• A pooled analysis of advanced colorectal neoplasia diagnoses after colonoscopic polypectomy.

  2009cited by this paper
• Sessile Serrated Adenoma (SSA) vs. Traditional Serrated Adenoma (TSA)

  2008cited by this paper
• Aurora kinase expression in colorectal adenocarcinoma: correlations with clinicopathological features, p16 expression, and telomerase activity.

  2008cited by this paper
• CpG Island Methylator Phenotype Associates with Low-Degree Chromosomal Abnormalities in Colorectal Cancer

  2008cited by this paper
• Frequent overexpression of Aurora Kinase A in upper gastrointestinal adenocarcinomas correlates with potent antiapoptotic functions

  2008cited by this paper
• Multiple putative oncogenes at the chromosome 20q amplicon contribute to colorectal adenoma to carcinoma progression

  2008cited by this paper
• Colorectal serrated adenocarcinoma

  2007cited by this paper
• Chromosomal 20q gain in the DNA diploid component of aneuploid colorectal carcinomas

  2007cited by this paper
• Subcellular Localization of the Spindle Proteins Aurora A, Mad2, and BUBR1 Assessed by Immunohistochemistry

  2007cited by this paper
• High copy amplification of the aurora-A gene is associated with chromosomal instability phenotype in human colorectal cancers

  2007cited by this paper
• Aurora-A kinase interacting protein 1 (AURKAIP1) promotes Aurora-A degradation through an alternative ubiquitin-independent pathway.

  2007cited by this paper
• Advanced colorectal polyps with the molecular and morphological features of serrated polyps and adenomas: concept of a ‘fusion’ pathway to colorectal cancer

  2006cited by this paper
• American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer.

  2006cited by this paper
• Centrosome‐, chromosomal‐passenger‐ and cell‐cycle‐associated mRNAs are differentially regulated in the development of sporadic colorectal cancer

  2006cited by this paper
• Senescence and serration: a new twist to an old tale

  2006cited by this paper
• Demographic and pathological characteristics of serrated polyps of colorectum

  2005cited by this paper
• Apoptosis Index and Apoptosis-Related Antigen Expression in Serrated Adenoma of the Colorectum: The Saw-Toothed Structure May Be Related to Inhibition of Apoptosis

  2002cited by this paper
• Colorectal adenoma to carcinoma progression follows multiple pathways of chromosomal instability.

  2002cited by this paper
• Emerging concepts in colorectal neoplasia.

  2002cited by this paper
• A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

  1998cited by this paper
• Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup.

  1993cited by this paper
• Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup.

  1993cited by this paper
• Risk of colorectal cancer in adenoma‐bearing individuals within a defined population

  1986cited by this paper

• Discovery of N-(3-fluorophenyl)-2-(4-((7-(1-methyl-1H-pyrazol-4-yl)quinazolin-4-yl)amino)phenyl)acetamide as the first orally active selective aurora kinase B inhibitor.

  2025cites this paper
• Discovery of a Potent and Highly Selective Inhibitor of Aurora A Kinase.

  2025cites this paper
• RNAi delivery mediated by milk extracellular vesicles in colon cancer

  2025cites this paper
• A comprehensive review on role of Aurora kinase inhibitors (AKIs) in cancer therapeutics.

  2024cites this paper
• AURORA KINASES: THEIR ROLE IN CANCER AND CELLULAR PROCESSES

  2024cites this paper
• WGCNA and Network Pharmacology Reveal Targets and Mechanisms of Action of Berberine in Colorectal Cancer Treatment

  2024cites this paper
• Discovery of a first-in-class Aurora A covalent inhibitor for the treatment of triple negative breast cancer.

  2023cites this paper
• Exploring Core Genes by Comparative Transcriptomics Analysis for Early Diagnosis, Prognosis, and Therapies of Colorectal Cancer

  2023cites this paper
• A Comprehension on Synthetic Strategies of Aurora kinase A and B Inhibitors

  2023cites this paper
• Comprehensive analysis identifies as a critical prognostic prediction gene in breast cancer

  2022cites this paper
• Aurora Kinase A Is an Independent Predictor of Invasive Recurrence in Breast Ductal Carcinoma in situ

  2022cites this paper
• Sequential gene expression analysis of cervical malignant transformation identifies RFC4 as a novel diagnostic and prognostic biomarker

  2022cites this paper
• Role of Stress-Survival Pathways and Transcriptomic Alterations in Progression of Colorectal Cancer: A Health Disparities Perspective

  2021cites this paper
• Knockdown of AURKA sensitizes the efficacy of radiation in human colorectal cancer.

  2021cites this paper
• Aurora kinase inhibitors as potential anticancer agents: Recent advances.

  2021cites this paper
• Aurora B kinase: a potential drug target for cancer therapy

  2021cites this paper
• Current progress, challenges and future prospects of indazoles as protein kinase inhibitors for the treatment of cancer

  2021cites this paper
• Bioinformatics Analysis of Global Proteomic and Phosphoproteomic Data Sets Revealed Activation of NEK2 and AURKA in Cancers

  2020cites this paper
• The landscape of genomic copy number alterations in colorectal cancer and their consequences on gene expression levels and disease outcome.

  2019cites this paper
• Novel combination strategies with Aurora Kinase Inhibitors : using pre-clinical data to guide clinical trial design

  2019influential citation
• Increased AURKA Gene Copy Number Correlates with Poor Prognosis and Predicts the Efficacy of High-dose Interferon Therapy in Acral Melanoma

  2018cites this paper
• The role of Aurora-A in cancer stem cells.

  2018cites this paper
• Aurora kinases: novel therapy targets in cancers

  2017cites this paper
• Endoscopic and molecular characterization of colorectal sessile serrated adenoma/polyps with cytologic dysplasia.

  2017cites this paper
• Immunohistochemical Expression of Heparanase Isoforms and Syndecan-1 Proteins in Colorectal Adenomas

  2016cites this paper
• Over-expression of AURKA, SKA3 and DSN1 contributes to colorectal adenoma to carcinoma progression

  2016cites this paper
• Aurora Kinase A Is a Prognostic Marker in Colorectal Adenocarcinoma

  2016influential citation