Unusual site of Langerhans cell histiocytosis: cervical and vaginal involvement

Liang Song,Qingli Li,R. Yin,Danqing Wang

Published 2019 in Journal of Obstetrics and Gynaecology Research

ABSTRACT

Langerhans cell histiocytosis (LCH) is a rare disorder with many morphological features that involve alterations in the immunohistochemical markers of Langerhans cells and in clonal neoplastic histiocyte proliferation. Clinically, LCH can present as a limited indolent disease, a chronic progressive disease, or a fulminant systemic illness. Lesions can appear in multiple areas; however, an LCH lesion localised to the cervix and vagina is uncommon. Genital LCH in adults is unusual and the rarity of cervical and vaginal LCH precludes the determination of the best staging procedures and treatments. We describe a Chinese woman with cervical and vaginal LCH.

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