Acute hazard of biocides for the aquatic environmental compartment from a life-cycle perspective.

One of the aims of the European project LIFE-COMBASE is to build a computational tool to predict the acute toxicity for aquatic organisms of biocidal active substances and its environmental degradation products. A database was implemented compiling toxicity data for these substances in organisms of the freshwater/marine and sewage treatment plant compartments. The goal of this study is to analyze the compiled data to identify the possible hazard of these compounds for the aquatic compartments. Several official and scientific databases were consulted. Data from 196 biocidal substances and 206 environmental metabolites were collected for the taxonomic groups, including fish, invertebrates, algae and sewage treatment plant (STP) microorganisms. Substances were categorized for their toxicity in four groups, considering values of L(E)C50, according to EU Regulation (EC) No 1272/2008. >50% of the parent were located in category 1 (L(E)C50 ≤ 1 mg/L) for fish, invertebrates and algae, indicating a high toxicity for the freshwater/marine compartments. However >60% were not toxic for STP microorganisms. Metabolites were mainly less toxic than the parent compounds, but 22-36% presented the same toxicity and ~6% were more toxic. No toxicological information was found for ~50% of the metabolites for fish, invertebrates and algae, reaching the 96% for the microorganisms. In addition, information on toxicity to the STP microorganisms was only found for 40% of the parent compounds. The high percentage of toxic metabolites and the scarcity of data for these compounds indicate the need to further study their impact in the aquatic compartments.

• Publication year

  2019

• Venue

  Science of the Total Environment

• Publication date

  2019-03-25

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1016/j.scitotenv.2018.12.186PMID 30579199
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Contact Details

  2023cited by this paper
• Risk assessment and risk management: Review of recent advances on their foundation

  2016cited by this paper
• Residue profiles of brodifacoum in coastal marine species following an island rodent eradication.

  2015cited by this paper
• Biocides in hydraulic fracturing fluids: a critical review of their usage, mobility, degradation, and toxicity.

  2015cited by this paper
• Acute aquatic toxicity of metofluthrin metabolites in the environment

  2013cited by this paper
• Risks of Using Antifouling Biocides in Aquaculture

  2012cited by this paper
• Occurrence of Azoxystrobin, Propiconazole, and Selected Other Fungicides in US Streams, 2005–2006

  2011cited by this paper
• Environmental Monitoring for Brodifacoum Residues after Aerial Application of Baits for Rodent Eradication

  2010cited by this paper
• Trends in EU biocides regulation

  2010cited by this paper
• Fate and toxicity of emerging pollutants, their metabolites and transformation products in the aquatic environment

  2008cited by this paper
• Is there a risk associated with the insect repellent DEET (N,N-diethyl-m-toluamide) commonly found in aquatic environments?

  2007cited by this paper
• Impact of surface water conditions on preservative leaching and aquatic toxicity from treated wood products.

  2007cited by this paper
• Assessing the ecotoxicity of pesticide transformation products.

  2003cited by this paper
• Survey for the occurrence of antifouling paint booster biocides in the aquatic environment of Greece

  2002cited by this paper
• An assessment of the toxicity of some pesticides and their metabolites affecting a natural aquatic environment using the Microtox™ system

  2000cited by this paper
• Regulatory requirements for biocides on the market in the European Union according to Directive 98/8/EC.

  1999cited by this paper
• Efficacy of plant metabolites of imidacloprid against Myzus persicae and Aphis gossypii (Homoptera: Aphididae)

  1998cited by this paper
• Determination of coal tar and creosote constituents in the aquatic environment.

  1997cited by this paper

• Analytical Approaches for Detecting Biocides in Aquatic Environments: Advances and Challenges

  2026cites this paper
• Retrospective trend analysis of biocides in suspended particulate matter of major German rivers

  2025cites this paper
• Recommendations for making the European Commission's Safe and Sustainable by Design framework practicable for biocides

  2025cites this paper
• The industrial biocide benzisothiazolinone impairs pathogen resistance in larval zebrafish by inducing microbiota dysbiosis.

  2025cites this paper
• Aurelia aurita as a Model for Ecotoxicologically Assessing Food Additives: 2-Methyl-1-phenylpropan-2-ol and 1-Phenylethan-1-ol

  2025cites this paper
• Zebrafish as a model for assessing biocide toxicity: A comprehensive review

  2025cites this paper
• Preliminary hazard assessment of a new nature-inspired antifouling (NIAF) agent.

  2024cites this paper
• Synergistic Enzybiotic Effect of a Bacteriophage Endolysin and an Engineered Glucose Oxidase Against Listeria

  2024cites this paper
• The broad-spectrum biocide triclosan trigonal crystal: experimental and DFT-calculated structural, electronic and optical properties

  2024cites this paper
• Long-term disinfectant exposure on intestinal immunity and microbiome variation of grass carp.

  2024cites this paper
• Innovative bioremediation of dexamethasone in aquatic ecosystems using Rhodococcus sp. D32: Pathway discovery and reduction of ecotoxicity

  2024cites this paper
• PBT assessment of chemicals detected in effluent of wastewater treatment plants by suspected screening analysis.

  2023cites this paper
• Remediation of Pesticides by Microalgae as Feasible Approach in Agriculture: Bibliometric Strategies

  2022cites this paper
• Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

  2021cites this paper
• Evaluation of Selected Chemicals used for Oil and Gas Production and Their Toxic Effects on the Niger Delta Fresh Water Tilapia Guineensis

  2021cites this paper
• Multidimensional characterization of a new antifouling xanthone: Structure-activity relationship, environmental compatibility, and immobilization in marine coatings.

  2021cites this paper
• Fish cell lines as screening tools to predict acute toxicity to fish of biocidal active substances and their relevant environmental metabolites.

  2021cites this paper
• Application, release, ecotoxicological assessment of biocide in building materials and its soil microbial response.

  2021cites this paper
• Antimicrobial potential of ZnO, TiO2 and SiO2 nanoparticles in protecting building materials from biodegradation

  2020cites this paper
• Carbendazim-clay complexes for its potential use as antimicrobial additives in mortars

  2020cites this paper
• Comparing in vivo data and in silico predictions for acute effects assessment of biocidal active substances and metabolites for aquatic organisms.

  2020cites this paper
• In Silico Ecotoxicological Modeling of Pesticide Metabolites and Mixtures

  2020cites this paper
• Synthesis and fouling resistance of capsaicin derivatives containing amide groups.

  2019cites this paper