Bacterial lipopolysaccharide induces mRNA expression of an IkappaB MAIL through toll-like receptor 4.

Molecule possessing ankyrin-repeats induced by lipopolysaccharide (MAIL) is a nuclear IkappaB protein recently identified as a molecule appearing in immunocompetent organs after administration of bacterial lipopolysaccharide (LPS). Participation of Toll-like receptor (TLR) 4, which is a major form of LPS receptors, in the LPS-induced MAIL expression was investigated. When a human myelomonocytic cell line U937 was treated with phorbol 12-myristate 13-acetate for 3 days, the LPS-induced MAIL expression was much potentiated in parallel with an increase in TLR4 expression. The MAIL induction was attenuated when the cells were treated with a neutralizing antibody against TLR4. The in vivo induction of MAIL in the spleen was smaller in mice having a missense mutation of the Tlr4 gene than in normal control mice. These results collectively indicate that TLR4 contributes, at least in part, MAIL induction after LPS stimulation.

• Publication year

  2002

• Venue

  Journal of Veterinary Medical Science

• Publication date

  2002-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1292/JVMS.64.419PMID 12069074
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genomic organization, chromosomal localization, and promoter analysis of the mouse Mail gene

  2001cited by this paper
• Human Nod1 Confers Responsiveness to Bacterial Lipopolysaccharides*

  2001cited by this paper
• A Novel IκB Protein, IκB-ζ, Induced by Proinflammatory Stimuli, Negatively Regulates Nuclear Factor-κB in the Nuclei*

  2001cited by this paper
• A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei.

  2001cited by this paper
• Toll-like receptors in the induction of the innate immune response

  2000influential reference
• Innate recognition of lipopolysaccharide by Toll-like receptor 4/MD-2 and RP105/MD-1

  2000cited by this paper
• MAIL, a novel nuclear I kappa B protein that potentiates LPS-induced IL-6 production.

  2000cited by this paper
• Critical roles of Toll-like receptors in host defense.

  2000cited by this paper
• MAIL, a novel nuclear IκB protein that potentiates LPS‐induced IL‐6 production

  2000cited by this paper
• A Toll-like receptor recognizes bacterial DNA

  2000cited by this paper
• Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 (Tlr4)

  1999cited by this paper
• The Toll-receptor family and control of innate immunity.

  1999cited by this paper
• MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4

  1999cited by this paper
• Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.

  1998cited by this paper
• The Human Toll Signaling Pathway: Divergence of Nuclear Factor κB and JNK/SAPK Activation Upstream of Tumor Necrosis Factor Receptor–associated Factor 6 (TRAF6)

  1998cited by this paper
• Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin.

  1995influential reference
• Bacterial endotoxin: molecular relationships of structure to activity and function

  1994cited by this paper
• Human Leukemic Models of Myelomonocytic Development: A Review of the HL‐60 and U937 Cell Lines

  1985influential reference
• Gene Product Lps the Lipopolysaccharide: Evidence for TLR4 as to (TLR4)-Deficient Mice Are Hyporesponsive Cutting Edge: Toll-Like Receptor 4

  year unknowncited by this paper

• The central inflammatory regulator IκBζ: induction, regulation and physiological functions

  2023cites this paper
• Direct inhibition of the TLR4/MyD88 pathway by geniposide suppresses HIF‐1α‐independent VEGF expression and angiogenesis in hepatocellular carcinoma

  2020cites this paper
• Region Specific Effects of Maternal Immune Activation on Offspring Neuroimmune Function

  2015cites this paper
• Molecular modeling‐based evaluation of dual function of IκBζ ankyrin repeat domain in toll‐like receptor signaling

  2011cites this paper
• Upregulation of chemokine (C–C motif) ligand 20 in adult epidermal keratinocytes in direct current electric fields

  2010cites this paper
• Increased expression of MAIL, a cytokine-associated nuclear protein, in the prodromal stage of black walnut-induced laminitis.

  2010cites this paper
• Expression of innate resistance factors in mammary secretion from periparturient dairy heifers and their association with subsequent infection status.

  2009cites this paper
• A Novel Role for IκBζ in the Regulation of IFNγ Production

  2009cites this paper
• Interleukin (IL)-10 attenuates lipopolysaccharide-induced IL-6 production via inhibition of IκB-ζ activity by Bcl-3

  2009cites this paper
• The nuclear I kappaB protein I kappaB zeta specifically binds NF-kappaB p50 homodimers and forms a ternary complex on kappaB DNA.

  2008cites this paper
• Role of NF-κB in Constitutive Expression of MAIL in Epidermal Keratinocytes

  2007cites this paper
• Genome-wide expression profiling of placentas in the p57Kip2 model of pre-eclampsia.

  2007cites this paper
• Role of NF-kappaB in constitutive expression of MAIL in epidermal keratinocytes.

  2007cites this paper
• IkappaB-zeta: an inducible regulator of nuclear factor-kappaB.

  2006cites this paper
• IκB‐ζ: An Inducible Regulator of Nuclear Factor‐κB

  2006cites this paper
• Murine Macrophage Transcriptional Responses to Bacillus anthracis Infection and Intoxication

  2005cites this paper
• Expression of Toll‐like Receptors in Human Endometrial Epithelial Cells and Cell Lines

  2004cites this paper
• Cloning of bovine MAIL and its mRNA expression in white blood cells of Holstein cows.

  2004cites this paper
• Interactions between lipopolysaccharide and the intestinal epithelium.

  2004cites this paper
• Inflammation of the cystic fibrosis mouse small intestine.

  2004cites this paper
• Identification of novel expressed sequences, up‐regulated in the leucocytes of chronic fatigue syndrome patients

  2003cites this paper
• Bacterial lipopolysaccharide-induced expression of the IkappaB protein MAIL in B-lymphocytes and macrophages.

  2003cites this paper