The Rac-GAP Bcr is a novel regulator of the Par complex that controls cell polarity

The Par complex (Par3, Par6, and PKCζ) controls cell polarity, which is essential for many biological processes. Here we identify the Rac1 GTPase-activating protein Bcr as an integral member of the Par complex that regulates polarized cell migration by locally restricting both Rac1 and PKCζ function.

• Publication year

  2013

• Venue

  Molecular Biology of the Cell

• Publication date

  2013-12-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/mbc.E13-06-0333PMID 24152735PMCID 3861082
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• PAR6B is required for tight junction formation and activated PKCζ localization in breast cancer.

  2012cited by this paper
• 2012 Landes Bioscience. Do not distribute. The Rac activator Tiam1 is required for polarized protrusional outgrowth of primary astrocytes by affecting the organization of the microtubule network

  2012cited by this paper
• Cell polarity proteins and cancer.

  2012cited by this paper
• Targeting Rho GTPase signaling for cancer therapy.

  2012cited by this paper
• Role of Rho GTPases and their regulators in cancer progression.

  2011cited by this paper
• The PAR-6 polarity protein regulates dendritic spine morphogenesis through p190 RhoGAP and the Rho GTPase.

  2008cited by this paper
• Phosphatidylinositol-3-Kinase–Atypical Protein Kinase C Signaling Is Required for Wnt Attraction and Anterior–Posterior Axon Guidance

  2008cited by this paper
• Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation.

  2008cited by this paper
• Par complex in cancer: a regulator of normal cell polarity joins the dark side

  2008cited by this paper
• Polarity proteins in glial cell functions.

  2008cited by this paper
• Crosstalk between small GTPases and polarity proteins in cell polarization

  2008cited by this paper
• The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development

  2007cited by this paper
• Current knowledge of the large RhoGAP family of proteins

  2007cited by this paper
• The Par-Tiam1 complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity.

  2007cited by this paper
• Tiam1 takes PARt in cell polarity.

  2006cited by this paper
• In vitro assay of primary astrocyte migration as a tool to study Rho GTPase function in cell polarization.

  2006cited by this paper
• Abr and Bcr, Two Homologous Rac GTPase-Activating Proteins, Control Multiple Cellular Functions of Murine Macrophages

  2006cited by this paper
• mPar6α Controls Neuronal Migration

  2006cited by this paper
• mPar6 alpha controls neuronal migration.

  2006cited by this paper
• The Polarity Protein Par-3 Directly Interacts with p75NTR to Regulate Myelination

  2006cited by this paper
• The polarity protein PAR-3 and TIAM1 cooperate in dendritic spine morphogenesis

  2006cited by this paper
• Cdc42 controls the polarity of the actin and microtubule cytoskeletons through two distinct signal transduction pathways

  2005cited by this paper
• Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer.

  2005cited by this paper
• Par-3 controls tight junction assembly through the Rac exchange factor Tiam1

  2005cited by this paper
• Atypical Protein Kinase Cι Plays a Critical Role in Human Lung Cancer Cell Growth and Tumorigenicity*

  2005cited by this paper
• Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells.

  2005cited by this paper
• The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines.

  2005cited by this paper
• Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer.

  2005cited by this paper
• PAR-6–PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1

  2005cited by this paper
• Atypical protein kinase Cι is an oncogene in human non-small cell lung cancer

  2005cited by this paper
• Rational design and characterization of a Rac GTPase-specific small molecule inhibitor.

  2004cited by this paper
• New synaptic bouton formation is disrupted by misregulation of microtubule stability in aPKC mutants.

  2004cited by this paper
• Cdc42 - the centre of polarity

  2004cited by this paper
• APC and GSK-3β Are Involved in mPar3 Targeting to the Nascent Axon and Establishment of Neuronal Polarity

  2004cited by this paper
• Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity

  2003cited by this paper
• Cell polarity: Par6, aPKC and cytoskeletal crosstalk.

  2003cited by this paper
• Spatial and temporal analysis of Rac activation during live neutrophil chemotaxis.

  2002cited by this paper
• Guanine nucleotide exchange factors for Rho GTPases: turning on the switch.

  2002cited by this paper
• Rho GTPases in cell biology

  2002cited by this paper
• The promise and perils of Wnt signaling through beta-catenin.

  2002cited by this paper
• The Promise and Perils of Wnt Signaling Through β-Catenin

  2002cited by this paper
• Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta.

  2001cited by this paper
• Rho GTPases and cell migration.

  2001cited by this paper
• A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCζ signaling and cell transformation

  2000cited by this paper
• Localized Rac activation dynamics visualized in living cells.

  2000cited by this paper
• A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation.

  2000cited by this paper
• Activation of Atypical Protein Kinase C ζ by Caspase Processing and Degradation by the Ubiquitin-Proteasome System*

  2000cited by this paper
• Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt‐mediated regulation of LEF‐1

  1999cited by this paper
• Matrix-dependent Tiam1/Rac Signaling in Epithelial Cells Promotes Either Cell–Cell Adhesion or Cell Migration and Is Regulated by Phosphatidylinositol 3-Kinase

  1998cited by this paper
• 1 The chimeric BCR-ABL gene

  1997cited by this paper
• Involvement of phosphatidylinositide 3'-kinase and Rac in platelet-derived growth factor-induced actin reorganization and chemotaxis.

  1997cited by this paper
• The chimeric BCR-ABL gene.

  1997cited by this paper

• BCR-ABL: The molecular mastermind behind chronic myeloid leukemia.

  2025cites this paper
• Targeting Tiam1 Enhances Hippocampal-Dependent Learning and Memory in the Adult Brain and Promotes NMDA Receptor-Mediated Synaptic Plasticity and Function

  2024cites this paper
• EspH interacts with the host active Bcr related (ABR) protein to suppress RhoGTPases

  2022cites this paper
• Rac-maninoff and Rho-vel: The symphony of Rho-GTPase signaling at excitatory synapses

  2021cites this paper
• Colocalization of BCR Protein with Clathrin, Actin, and Cortactin Suggests Its Possible Role in the Regulation of Actin Branching and Clathrin-Mediated Endocytosis

  2021cites this paper
• Colocalization of BCR Protein with Clathrin, Actin, and Cortactin Suggests Its Possible Role in the Regulation of Actin Branching and Clathrin-Mediated Endocytosis

  2021cites this paper
• Establishment and Maintenance of Epithelial Polarization

  2020cites this paper
• The Rac-GEF Tiam1 Promotes Dendrite and Synapse Stabilization of Dentate Granule Cells and Restricts Hippocampal-Dependent Memory Functions

  2020cites this paper
• BCR: a promiscuous fusion partner in hematopoietic disorders

  2019cites this paper
• Multiple genomic copy number variants associated with periventricular nodular heterotopia indicate extreme genetic heterogeneity

  2019cites this paper
• CNTNAP2 is targeted to endosomes by the polarity protein Par3

  2019cites this paper
• Genes to Cells

  2018cites this paper
• FRET biosensor allows spatio-temporal observation of shear stress-induced polar RhoGDIα activation

  2018cites this paper
• The Unwanted Cell Migration in the Brain: Glioma Metastasis

  2017cites this paper
• Par3 integrates Tiam1 and phosphatidylinositol 3-kinase signaling to change apical membrane identity

  2017cites this paper
• Rho GTPase‐activating proteins: Regulators of Rho GTPase activity in neuronal development and CNS diseases

  2017cites this paper
• GABARAP proteins as scaffolds in localized TIAM1-RAC1 signaling

  2016cites this paper
• Cell polarity signaling in the plasticity of cancer cell invasiveness

  2016cites this paper
• CDK5 knockdown in astrocytes provide neuroprotection as a trophic source via Rac1.

  2015cites this paper
• Mechanisms for spatiotemporal regulation of Rho-GTPase signaling at synapses.

  2015influential citation
• The Scribble–Dlg–Lgl Module in Cell Polarity Regulation

  2015cites this paper
• Myo19 Ensures Symmetric Partitioning of Mitochondria and Coupling of Mitochondrial Segregation to Cell Division

  2014cites this paper
• Host cell polarity proteins participate in innate immunity to Pseudomonas aeruginosa infection.

  2014cites this paper
• Dynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex.

  2014cites this paper