The MRP1-Mediated Effluxes of Arsenic and Antimony Do Not Require Arsenic–Glutathione and Antimony–Glutathione Complex Formation

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Bioenergetics and Biomembranes

• Publication date

  2002-04-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1023/A:1015180026665PMID 12018890
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Treatment of Acute Promyelocytic Leukemia with Arsenic Trioxide

  2001cited by this paper
• Kinetics of glutathione and daunorubicin efflux from multidrug resistance protein overexpressing small-cell lung cancer cells.

  2001cited by this paper
• Role of glutathione in the biliary excretion of the arsenical drugs trimelarsan and melarsoprol.

  2000cited by this paper
• Biliary and urinary excretion of inorganic arsenic: monomethylarsonous acid as a major biliary metabolite in rats.

  2000cited by this paper
• The MRP2/cMOAT Transporter and Arsenic-Glutathione Complex Formation Are Required for Biliary Excretion of Arsenic*

  2000cited by this paper
• Differential sensitivities of MRP1-overexpressing lung tumor cells to cytotoxic metals.

  1999cited by this paper
• Overexpression of the multidrug resistance‐associated protein (MRP1) in human heavy metal‐selected tumor cells

  1999cited by this paper
• ATP‐ and glutathione‐dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1

  1999cited by this paper
• Kinetics of anthracycline efflux from multidrug resistance protein-expressing cancer cells compared with P-glycoprotein-expressing cancer cells.

  1998cited by this paper
• Characterization of vincristine transport by the M(r) 190,000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione.

  1998cited by this paper
• Reversal of heavy metal resistance in multidrug-resistant human KB carcinoma cells.

  1997cited by this paper
• Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines.

  1997cited by this paper
• Genetic dissection of the function of mammalian P-glycoproteins.

  1997cited by this paper
• Enzymatic methylation of arsenic species and other new approaches to arsenic toxicity.

  1997cited by this paper
• Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients.

  1997cited by this paper
• Acute promyelocytic leukemia: cellular and molecular basis of differentiation and apoptosis.

  1997cited by this paper
• Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania.

  1996cited by this paper
• ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump.

  1996cited by this paper
• Efflux-mediated resistance to arsenicals in arsenic-resistant and -hypersensitive Chinese hamster cells.

  1996cited by this paper
• An ATP-dependent As(III)-glutathione transport system in membrane vesicles of Leishmania tarentolae.

  1996cited by this paper
• Relation among the resistance factor, kinetics of uptake, and kinetics of the P-glycoprotein-mediated efflux of doxorubicin, daunorubicin, 8-(S)-fluoroidarubicin, and idarubicin in multidrug-resistant K562 cells.

  1996cited by this paper
• New mechanisms of drug resistance in parasitic protozoa.

  1995cited by this paper
• Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein.

  1995cited by this paper
• Reduction and binding of arsenate and dimethylarsinate by glutathione: a magnetic resonance study.

  1994cited by this paper
• Reactions of arsenic(III) and arsenic(V) species with glutathione.

  1993cited by this paper
• Increased biliary excretion of glutathione is generated by the glutathione-dependent hepatobiliary transport of antimony and bismuth.

  1992cited by this paper
• The use of monochlorobimane to determine hepatic GSH levels and synthesis.

  1990cited by this paper
• Multifactorial drug resistance in an adriamycin-resistant human small cell lung carcinoma cell line.

  1987cited by this paper
• The reaction of methylarsenicals with thiols: Some biological implications

  1984cited by this paper

• Arsenome, Arsenobolome, and Arsenobiolome

  2025cites this paper
• Glutathione-Coordinated Metal Complexes as Substrates for Cellular Transporters.

  2021cites this paper
• Arsenic induced alteration in Mrp-1 like activity leads to zebrafish hepatocyte apoptosis: the cellular GSH connection.

  2020cites this paper
• Highly sensitive simultaneous electrochemical determination of reduced and oxidized glutathione in urine samples using antimony trioxide modified carbon paste electrode

  2020cites this paper
• Defining the mechanism of the mitochondrial Atm1p [2Fe-2S] cluster exporter.

  2020cites this paper
• Antimony(III) induces fibroblast-like phenotype, profibrotic factors and reactive oxygen species in mouse renal cells

  2020cites this paper
• Effects of Proanthocyanidins on Arsenic Methylation Metabolism and Efflux in Human Hepatocytes L-02

  2019cites this paper
• The A‐B‐C of small‐molecule ABC transport protein modulators: From inhibition to activation—a case study of multidrug resistance‐associated protein 1 (ABCC1)

  2019cites this paper
• Update onarsenic Exposure Link inCancer

  2017cites this paper
• Placental ABC Transporters: Biological Impact and Pharmaceutical Significance

  2016cites this paper
• Cellular arsenic transport pathways in mammals.

  2016cites this paper
• Synthesis, Structures, Luminescent and Magnetic Properties of Heterometallic 5p-4f Compounds with Ethylenediaminetetra­acetate

  2013cites this paper
• Arsenic-glutathione conjugate transport by the human multidrug resistance proteins (MRPs/ABCCs).

  2012cites this paper
• Efflux of Glutathione and Glutathione Complexes from Human Erythrocytes in Response to Inorganic Arsenic Exposure

  2012cites this paper
• Factors Determining Sensitivity and Resistance of Tumor Cells to Arsenic Trioxide

  2012influential citation
• Arsenate V induced glutathione efflux from human erythrocytes.

  2012cites this paper
• Environmental chemicals as substrates, inhibitors or inducers of drug transporters: implication for toxicokinetics, toxicity and pharmacokinetics

  2012cites this paper
• Structural and functional properties of human multidrug resistance protein 1 (MRP1/ABCC1).

  2011cites this paper
• ARSENIC TRIOXIDE INDUCES A BECLIN-1 INDEPENDENT AUTOPHAGIC PATHWAY VIA MODULATION OF SNON/SKIL EXPRESSION IN OVARIAN CARCINOMA CELLS

  2010cites this paper
• The role of ABC transporters in protecting cells from bilirubin toxicity.

  2009cites this paper
• Stability of arsenic peptides in plant extracts: off-line versus on-line parallel elemental and molecular mass spectrometric detection for liquid chromatographic separation

  2009cites this paper
• RECENT DEVELOPMENTS IN THE FIELD OF ANTICANCER METALLOPHARMACEUTICALS

  2009cites this paper
• Resistance against novel anticancer metal compounds: differences and similarities.

  2008cites this paper
• Glutathione-dependent interaction of heavy metal compounds with multidrug resistance proteins MRP1 and MRP2.

  2008cites this paper
• The nitric oxide-iron interplay in mammalian cells: transport and storage of dinitrosyl iron complexes.

  2008cites this paper
• Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development.

  2008cites this paper
• Establishment of an Arsenic Trioxide—Resistant Human Leukemia Cell Line That Shows Multidrug Resistance

  2007cites this paper
• Molecular processes in cellular arsenic metabolism.

  2007cites this paper
• DNICs and intracellular iron: nitrogen monoxide (NO)-mediated iron release from cells is linked to NO-mediated glutathione efflux via MRP1

  2007cites this paper
• Radicals for life : the various forms of nitric oxide

  2007cites this paper
• Differential toxicity of antimonial compounds and their effects on glutathione homeostasis in a human leukaemia monocyte cell line.

  2006cites this paper
• Multidrug resistance associated protein 1 protects against bilirubin‐induced cytotoxicity

  2006cites this paper
• Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins.

  2006cites this paper
• Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense.

  2005cites this paper
• MRP-1 expression levels determine strain-specific susceptibility to sodium arsenic-induced renal injury between C57BL/6 and BALB/c mice.

  2005cites this paper
• Arsenic trioxide circumvents multidrug resistance based on different mechanisms in human leukemia cell lines.

  2005cites this paper
• Equilibrium characterization of the As(III)-cysteine and the As(III)-glutathione systems in aqueous solution.

  2004cites this paper
• The human multidrug-resistance-associated protein MRP1 mediates ATP-dependent transport of unconjugated bilirubin.

  2004cites this paper
• The MRP-related and BCRP/ABCG2 multidrug resistance proteins: biology, substrate specificity and regulation.

  2004cites this paper
• Overexpression of phytochelatin synthase in Arabidopsis leads to enhanced arsenic tolerance and cadmium hypersensitivity.

  2004cites this paper
• Arsenic Transport by the Human Multidrug Resistance Protein 1 (MRP1/ABCC1)

  2004cites this paper
• 29 Inorganic pharmaceuticals

  2003cites this paper
• A Region within a Lumenal Loop of Saccharomyces cerevisiae Ycf1p Directs Proteolytic Processing and Substrate Specificity

  2003cites this paper
• Kinetic analysis of rhodamines efflux mediated by the multidrug resistance protein (MRP1).

  2003cites this paper
• Multidrug resistance‐associated proteins: Export pumps for conjugates with glutathione, glucuronate or sulfate

  2003cites this paper