Phenotypic characterization of epiphycan-deficient and epiphycan/biglycan double-deficient mice.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Osteoarthritis and Cartilage

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.joca.2009.11.006PMID 19932218PMCID PMC3013283
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Identification of opticin, a member of the small leucine-rich repeat proteoglycan family, in human articular tissues: a novel target for MMP-13 in osteoarthritis.

  2008cited by this paper
• Decorin Modulates Fibrin Assembly and Structure*

  2006cited by this paper
• Comparative analysis of gene expression profiles in intact and damaged regions of human osteoarthritic cartilage.

  2006cited by this paper
• Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis.

  2006cited by this paper
• Replication of the association of the aspartic acid repeat polymorphism in the asporin gene with knee-osteoarthritis susceptibility in Han Chinese

  2006cited by this paper
• The structure and function of cartilage proteoglycans.

  2006cited by this paper
• Extracellular superoxide dismutase and oxidant damage in osteoarthritis.

  2005cited by this paper
• An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis

  2005cited by this paper
• Interactions of the Extracellular Matrix Proteoglycans Decorin and Biglycan with C1q and Collectins1

  2005cited by this paper
• Repression of anti-proliferative factor Tob1 in osteoarthritic cartilage

  2005cited by this paper
• The Extracellular Matrix and Inflammation

  2005cited by this paper
• The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages.

  2005cited by this paper
• Gene Expression in Chondrocytes Assessed with Use of Microarrays

  2003cited by this paper
• Identification and Characterization of a Novel Interaction between Pulmonary Surfactant Protein D and Decorin*

  2003cited by this paper
• Abnormal collagen fibrils in tendons of biglycan/fibromodulin‐deficient mice lead to gait impairment, ectopic ossification, and osteoarthritis

  2002cited by this paper
• Annexin VIII Is Differentially Expressed by Chondrocytes in the Mammalian Growth Plate During Endochondral Ossification and in Osteoarthritic Cartilage

  2002cited by this paper
• A Syndrome of Joint Laxity and Impaired Tendon Integrity in Lumican- and Fibromodulin-deficient Mice* 210

  2002cited by this paper
• Fibromodulin-null murine knee joints display increased incidences of osteoarthritis and alterations in tissue biochemistry.

  2002cited by this paper
• Deletion of estrogen receptors reveals a regulatory role for estrogen receptors-beta in bone remodeling in females but not in males.

  2002cited by this paper
• Mice deficient in small leucine-rich proteoglycans: novel in vivo models for osteoporosis, osteoarthritis, Ehlers-Danlos syndrome, muscular dystrophy, and corneal diseases.

  2002cited by this paper
• Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application

  2001cited by this paper
• Identification and Characterization of Asporin

  2001cited by this paper
• Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNA-array technology.

  2001cited by this paper
• Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection.

  2001cited by this paper
• Fibromodulin and lumican bind to the same region on collagen type I fibrils

  2000cited by this paper
• Expression and localization of PG‐Lb/epiphycan during mouse development

  1999influential reference
• The Biology of the Small Leucine-rich Proteoglycans

  1999cited by this paper
• Severe disturbance of the distribution and expression of type VI collagen chains in osteoarthritic articular cartilage.

  1998cited by this paper
• Evidence for a prostate cancer susceptibility locus on the X chromosome.

  1998cited by this paper
• Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice

  1998cited by this paper
• Lumican Regulates Collagen Fibril Assembly: Skin Fragility and Corneal Opacity in the Absence of Lumican

  1998cited by this paper
• Changes in messenger RNA and protein levels of proteoglycans and link protein in human osteoarthritic cartilage samples.

  1997cited by this paper
• Occurrence of PG-Lb, a leucine-rich small chondroitin/dermatan sulphate proteoglycan in mammalian epiphyseal cartilage: molecular cloning and sequence analysis of the mouse cDNA.

  1996cited by this paper
• Eukaryotic Expression of Recombinant Biglycan

  1996cited by this paper
• Molecular Cloning and Tissue Distribution of Keratocan

  1996cited by this paper
• The Primary Structure of a Basic Leucine-rich Repeat Protein, PRELP, Found in Connective Tissues (*)

  1995cited by this paper
• Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration.

  1995cited by this paper
• Concentration and size distribution of insulin-like growth factor-I in human normal and osteoarthritic synovial fluid and cartilage.

  1995cited by this paper
• Antisera and cDNA probes to human and certain animal model bone matrix noncollagenous proteins.

  1995cited by this paper
• Large and small proteoglycans of osteoarthritic and rheumatoid articular cartilage.

  1995cited by this paper
• Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.

  1994cited by this paper
• The structure of a 38-kDa leucine-rich protein (chondroadherin) isolated from bovine cartilage.

  1994cited by this paper
• Interaction of heparin cofactor II with biglycan and decorin.

  1993cited by this paper
• The proteoglycan decorin binds C1q and inhibits the activity of the C1 complex.

  1992cited by this paper
• Proteoglycan-Lb, a small dermatan sulfate proteoglycan expressed in embryonic chick epiphyseal cartilage, is structurally related to osteoinductive factor.

  1992cited by this paper
• Genomic DNA microextraction: a method to screen numerous samples.

  1992cited by this paper
• Interactions between thrombospondin and the small proteoglycan decorin: interference with cell attachment.

  1992cited by this paper
• Negative regulation of transforming growth factor-beta by the proteoglycan decorin.

  1990cited by this paper
• Negative regulation of transforming growth factor-β by the proteoglycan decorin

  1990cited by this paper
• Immunohistochemical detection and immunochemical analysis of type II collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilages and in explants of bovine articular cartilage cultured with interleukin 1.

  1989cited by this paper
• Interaction of small dermatan sulfate proteoglycan from fibroblasts with fibronectin

  1987cited by this paper
• [Evaluation of the effect of analgesics/antiphlogistics on the progression of spontaneous arthrosis in the C57 black mouse].

  1983cited by this paper
• The tensile properties of the cartilage of human femoral condyles related to the content of collagen and glycosaminoglycans.

  1973cited by this paper

• Apolipoprotein E is a marker of all chondrocytes in the growth plate resting zone

  2025cites this paper
• Extracellular matrix dysregulation in aging, calcification, and cancer diseases: insights into cellular senescence, inflammation, and novel therapeutic strategies

  2025cites this paper
• The single-cell transcription reveals the aberrant differentiation trajectory of chondrocytes in the intervertebral disc for congenital scoliosis

  2025cites this paper
• Effects of immediate loading directionality on the mechanical sensing protein PIEZO1 expression and early-stage healing process of peri-implant bone

  2024cites this paper
• Apolipoprotein E is a novel marker for chondrocytes in the growth plate resting zone

  2024cites this paper
• Cartilage decellularized matrix hydrogel loaded with protocatechualdehyde for targeted epiphycan treatment of osteoarthritis

  2024cites this paper
• Osteomodulin downregulation is associated with osteoarthritis development

  2023cites this paper
• Unravelling the limb regeneration mechanisms of Polypedates maculatus, a sub-tropical frog, by transcriptomics

  2023cites this paper
• Unusual Suspects: Bone and Cartilage ECM Proteins as Carcinoma Facilitators

  2023cites this paper
• Osteomodulin down-regulation is associated with osteoarthritis development

  2023cites this paper
• Local depletion of proteoglycans mediates cartilage tissue repair in an ex vivo integration model.

  2022cites this paper
• Functions and applications of extracellular matrix in cartilage tissue engineering

  2022cites this paper
• Benefits of lumican on human bone health: clinical evidence using bone marrow aspirates

  2022cites this paper
• Mouse Models of Osteoarthritis: Surgical Model of Post-traumatic Osteoarthritis Induced by Destabilization of the Medial Meniscus.

  2021cites this paper
• Differentiated Activities of Decorin and Biglycan in the Progression of Post-Traumatic Osteoarthritis.

  2021cites this paper
• Lumican Inhibits Osteoclastogenesis and Bone Resorption by Suppressing Akt Activity

  2021cites this paper
• Males and Females Have Distinct Molecular Events in the Articular Cartilage during Knee Osteoarthritis

  2021cites this paper
• Epiphycan Predicts Poor Outcomes and Promotes Metastasis in Ovarian Cancer

  2021cites this paper
• The regulatory role of matrix proteins in mineralization of bone

  2021cites this paper
• Nanoscale Imaging and Analysis of Bone Pathologies

  2021cites this paper
• Osteoporosis and Osteoarthritis

  2021cites this paper
• Combining segmental bulk- and single-cell RNA-sequencing to define the chondrocyte gene expression signature in the murine knee joint

  2020cites this paper
• Decorin Regulates Cartilage Pericellular Matrix Micromechanobiology.

  2020cites this paper
• Palaeoproteomic identification of breast milk protein residues from the archaeological skeletal remains of a neonatal dog

  2019cites this paper
• Mechanisms of sterile inflammation in the testis

  2018cites this paper
• In vivo effect of opticin deficiency in cartilage in a surgically induced mouse model of osteoarthritis

  2018cites this paper
• Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production

  2018cites this paper
• Irx3 and Bmp2 regulate mouse mesenchymal cell chondrogenic differentiation in both a Sox9‐dependent and ‐independent manner

  2017cites this paper
• Molecular Genetics of the Cartilage Collagenopathies

  2017cites this paper
• Epiphycan is specifically expressed in cochlear supporting cells and is necessary for normal hearing.

  2017cites this paper
• Different responses of articular cartilage to strenuous running and joint immobilization

  2016cites this paper
• Novel therapeutic targets in osteoarthritis: Narrative review on knock-out genes involved in disease development in mouse animal models.

  2016cites this paper
• Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

  2015cites this paper
• Mouse models of osteoarthritis: surgical model of posttraumatic osteoarthritis induced by destabilization of the medial meniscus.

  2015cites this paper
• Posterior Amorphous Corneal Dystrophy Is Associated with a Deletion of Small Leucine-rich Proteoglycans on Chromosome 12

  2014cites this paper
• The role of small leucine-rich proteoglycans in osteoarthritis pathogenesis.

  2014cites this paper
• Skeletal analysis and differential gene expression in Runx2/Osterix double heterozygous embryos.

  2014cites this paper
• CRISPR/Cas9 mediated generation of stable chondrocyte cell lines with targeted gene knockouts; analysis of an aggrecan knockout cell line.

  2014cites this paper
• Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology.

  2014cites this paper
• Importance des glycosaminoglycanes de surface dans les phénomènes inflammatoires liés au cancer

  2014cites this paper
• Comparative Proteomic Analysis of Normal and Collagen IX Null Mouse Cartilage Reveals Altered Extracellular Matrix Composition and Novel Components of the Collagen IX Interactome*

  2013cites this paper
• The Composition of Bone

  2013cites this paper
• Characterisation of small leucine rich proteins gene and protein expression in mesenchymal stem cell differentiation into osteoblasts, adipocytes and chondrocytes

  2013cites this paper
• Small leucine-rich proteoglycans in the vertebrae of Atlantic salmon Salmo salar.

  2013cites this paper
• Animal Models of Bone Diseases-A

  2013cites this paper
• Dermatan 4-O-sulfotransferase1 ablation accelerates peripheral nerve regeneration.

  2013cites this paper
• Cartilage Extracellular Matrix Integrity and OA

  2012cites this paper
• The Biology of Small Leucine-rich Proteoglycans in Bone Pathophysiology*

  2012cites this paper
• Quantitative Proteomic Analysis of Eight Cartilaginous Tissues Reveals Characteristic Differences as well as Similarities between Subgroups*

  2012cites this paper
• Large‐scale mouse knockouts and phenotypes

  2012cites this paper
• Transcriptional Regulation of Proteoglycans and Glycosaminoglycan Chain-synthesizing Glycosyltransferases by UV Irradiation in Cultured Human Dermal Fibroblasts

  2011cites this paper
• Small Leucine-Rich Proteoglycans

  2011cites this paper
• A quantitative proteomics study of the additive effect of inflammatory cytokines and injurious compression on cartilage damage

  2011cites this paper
• Diseases of Aquatic Organisms Dis Aquat Org

  year unknowncites this paper