Repression of mammary adipogenesis by genistein limits mammosphere formation of human MCF-7 cells.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Journal of Endocrinology

• Publication date

  2013-07-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1530/JOE-12-0520PMID 23645249
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2011cited by this paper
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  2010cited by this paper
• Establishment of a Mammary Stromal Fibroblastic Cell Line for In Vitro Studies in Mice of Mammary Adipocyte Differentiation1

  2010influential reference
• Prevalence and trends in obesity among US adults, 1999-2008.

  2010cited by this paper
• Anti-inflammatory activity of soy and tea in prostate cancer prevention

  2010cited by this paper
• Physical activity, diet, adiposity and female breast cancer prognosis: a review of the epidemiologic literature.

  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
• Effects of isoflavones on breast density in pre- and post-menopausal women: a systematic review and meta-analysis of randomized controlled trials

  2010influential reference
• Targeting breast stem cells with the cancer preventive compounds curcumin and piperine

  2010cited by this paper
• Nanonized black soybean enhances immune response in senescence-accelerated mice

  2009cited by this paper
• Interleukin 6 Secreted from Adipose Stromal Cells Promotes Migration and Invasion of Breast Cancer Cells

  2009influential reference
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  2009cited by this paper
• Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation.

  2009cited by this paper
• Obesity and Cancer: The Role of Dysfunctional Adipose Tissue

  2009cited by this paper
• Early soy exposure via maternal diet regulates rat mammary epithelial differentiation by paracrine signaling from stromal adipocytes.

  2009influential reference
• A Comparative Analysis of Genistein and Daidzein in Affecting Lipid Metabolism in Rat Liver

  2009cited by this paper
• Genistein inhibits differentiation of primary human adipocytes.

  2009cited by this paper
• An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation.

  2009cited by this paper
• Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis.

  2009cited by this paper
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  2009cited by this paper
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  2008cited by this paper
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  2008cited by this paper
• Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy

  2008cited by this paper
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  2008cited by this paper
• Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthase.

  2008cited by this paper
• Epidemiology of soy exposures and breast cancer risk

  2008cited by this paper
• Indexing Techniques for CHR based on program transformation

  2007cited by this paper
• The effect of fat removal on glucose tolerance is depot specific in male and female mice.

  2007cited by this paper
• Increasing trends in incidence of overweight and obesity over 5 decades.

  2007cited by this paper
• Expression profiling of rat mammary epithelial cells reveals candidate signaling pathways in dietary protection from mammary tumors.

  2007cited by this paper
• Haplotype Mapping of a Diploid Non-Meiotic Organism Using Existing and Induced Aneuploidies

  2007cited by this paper
• The role of interleukin‐6 in insulin resistance, body fat distribution and energy balance

  2007cited by this paper
• Adiposity, the metabolic syndrome, and breast cancer in African-American and white American women.

  2007cited by this paper
• Interleukin‐6 and its receptor in cancer

  2007cited by this paper
• IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland.

  2007cited by this paper
• Plasma phytoestrogens and subsequent breast cancer risk.

  2007cited by this paper
• In utero exposure to maternal diets containing soy protein isolate, but not genistein alone, protects young adult rat offspring from NMU-induced mammary tumorigenesis.

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• Genistein decreases food intake, body weight, and fat pad weight and causes adipose tissue apoptosis in ovariectomized female mice.

  2006cited by this paper
• Reducing obesity and related chronic disease risk in children and youth: a synthesis of evidence with ‘best practice’ recommendations

  2006cited by this paper
• The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN.

  2005cited by this paper
• Inhibition of NMU-induced mammary tumorigenesis by dietary soy.

  2005cited by this paper
• Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms

  2004cited by this paper
• Prospective identification of tumorigenic breast cancer cells

  2003cited by this paper
• In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells.

  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
• Soy isoflavones increase latency of spontaneous mammary tumors in mice.

  2002cited by this paper
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  2002cited by this paper
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  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• Molecular regulation of adipogenesis.

  2000cited by this paper
• Effect of some phytoestrogens on metabolism of rat adipocytes.

  1999cited by this paper
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  1998cited by this paper
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  1997cited by this paper
• Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta.

  1997cited by this paper
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  1992cited by this paper
• [Interleukin-6 and its receptor].

  1991cited by this paper

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