Developmental atrazine exposure suppresses immune function in male, but not female Sprague-Dawley rats.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Toxicological Sciences

• Publication date

  2003-12-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1093/TOXSCI/KFG250PMID 14514952
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Changes in Cross-Fostered Sprague-Dawley Rat Litters Exposed to Perchlorate

  2003cited by this paper
• Defining critical windows in the development of the human immune system

  2002cited by this paper
• The effects of perinatal/juvenile heptachlor exposure on adult immune and reproductive system function in rats.

  2001cited by this paper
• Gonadotropin‐Releasing Hormone and G Proteins: Potential Roles in Autoimmunity

  2000cited by this paper
• Atrazine disrupts the hypothalamic control of pituitary-ovarian function.

  2000cited by this paper
• The effect of atrazine on puberty in male wistar rats: an evaluation in the protocol for the assessment of pubertal development and thyroid function.

  2000influential reference
• The effects of atrazine on female wistar rats: an evaluation of the protocol for assessing pubertal development and thyroid function.

  2000cited by this paper
• Occurrence and load of selected herbicides and metabolites in the lower Mississippi River.

  2000cited by this paper
• Development of the murine and human immune system: differential effects of immunotoxicants depend on time of exposure.

  2000cited by this paper
• Effect of atrazine on implantation and early pregnancy in 4 strains of rats.

  2000cited by this paper
• Maternal exposure to atrazine during lactation suppresses suckling-induced prolactin release and results in prostatitis in the adult offspring.

  1999influential reference
• Endocrine, immune, and behavioral effects of aldicarb (carbamate), atrazine (triazine) and nitrate (fertilizer) mixtures at groundwater concentrations

  1999influential reference
• Sexual dimorphism in the maturation of the pituitary-gonadal axis, assessed by GnRH agonist challenge.

  1999cited by this paper
• A risk characterization for atrazine: oncogenicity profile.

  1999cited by this paper
• Perinatal exposure to estrogenic compounds and the subsequent effects on the prostate of the adult rat: evaluation of inflammation in the ventral and lateral lobes.

  1999cited by this paper
• Pesticide use in the U.S. and policy implications: A focus on herbicides

  1999cited by this paper
• Manual of Immunological Methods

  1999cited by this paper
• Histological Studies of Atrazine Toxicity on the Thyroid Gland in Rats

  1996cited by this paper
• Induction of brain prolactin receptor long-form mRNA expression and maternal behavior in pup-contacted male rats: promotion by prolactin administration and suppression by female contact.

  1996cited by this paper
• Pituitary-thyroid axis and immune system: a reciprocal neuroendocrine-immune interaction.

  1995cited by this paper
• Regulation of rat luteinizing hormone beta gene expression in transgenic mice by steroids and a gonadotropin-releasing hormone antagonist.

  1995cited by this paper
• Chronic effects of atrazine on estrus and mammary tumor formation in female Sprague-Dawley and Fischer 344 rats.

  1994cited by this paper
• Comparison of ELISA and plaque-forming cell assays for measuring the humoral immune response to SRBC in rats and mice treated with benzo[a]pyrene or cyclophosphamide.

  1993cited by this paper
• Comparison of ELISA and Plaque-Forming Cell Assays for Measuring the Humoral Immune Response to SRBC in Rats and Mice Treated with Benzo[a]pyrene or Cyclophosphamide

  1993cited by this paper
• Limited immunotoxic potential of technical formulation of the herbicide atrazine (AAtrex) in mice.

  1992cited by this paper
• Developmental hormonal profiles accompanying the neonatal hypothyroidism-induced increase in adult testicular size and sperm production in the rat.

  1992cited by this paper
• Prolactin and Growth Hormone in the Regulation of the Immune System

  1991cited by this paper
• Attenuation of the suckling-induced prolactin release and the high afternoon oscillations of plasma prolactin secretion of lactating rats by antiserum to vasopressin.

  1991cited by this paper
• Immunotoxicologic assessment of subacute exposure of rats to carbon tetrachloride with comparison to hepatotoxicity and nephrotoxicity.

  1991cited by this paper
• Age- and sex-related effects on hepatic drug metabolism in rats chronically exposed to dietary atrazine.

  1991cited by this paper
• Long-Term Alteration of Adult Bone Marrow Colony Formation by Prenatal Chlordane Exposure

  1990cited by this paper
• Long-term alteration of adult bone marrow colony formation by prenatal chlordane exposure.

  1990cited by this paper
• Effect of neonatal prolactin deficiency on prepubertal tuberoinfundibular and tuberohypophyseal dopaminergic neuronal activity.

  1986cited by this paper
• Effect of neonatal prolactin deficiency on prepubertal tuberoinfundibular and tuberohypophyseal dopaminergic neuronal activity.

  1986cited by this paper
• Potential pesticide contamination of groundwater from agricultural uses.

  1984cited by this paper
• Exposure of neonatal female mice to diethylstilbestrol persistently impairs NK activity through reduction of effector cells at the bone marrow level.

  1984cited by this paper
• METHODS FOR TESTING IMMUNE EFFECTS OF TOXIC CHEMICALS: EVALUATION OF THE IMMUNOTOXICITY OF VARIOUS PESTICIDES IN THE RAT

  1983cited by this paper
• Immunomodulation by bromocriptine.

  1983cited by this paper
• Alterations of antibody response in female mice after neonatal exposure to diethylstilbestrol.

  1980cited by this paper
• Delayed hypersensitivity response to oxazolone in neonatally estrogenized mice.

  1978cited by this paper

• Evaluation of the immunotoxicity of atrazine and its chloro-metabolites: relevance for human cancer.

  2026cites this paper
• Immunotoxic effects in children resulting from prenatal and early childhood exposure to pesticides: A systematic review and meta-analysis.

  2025cites this paper
• Impact of environmental endocrine disruptors on adolescent sexual development: a comprehensive review with a focus on specific chemicals

  2025cites this paper
• Atrazine’s effects on mammalian physiology

  2025cites this paper
• Influence of triazines and lipopolysaccharide coexposure on inflammatory response and histopathological changes in the testis and liver of BalB/c mice

  2024cites this paper
• Hypoactivity and neurochemical alterations in the basal ganglia of female Sprague-Dawley rats after repeated exposure to atrazine

  2024cites this paper
• Atrazine exposure promotes cardiomyocyte pyroptosis to exacerbate cardiotoxicity by activating NF-κB pathway.

  2024cites this paper
• Effects of Atrazine exposure on human bone marrow-derived mesenchymal stromal cells assessed by combinatorial assay matrix

  2023cites this paper
• Rapid Multi-Residue Method for Simultaneous Determination of 1,3,5-Triazine Herbicides in Environmental Samples by Capillary GC-MS-EI Selective Ion Monitoring Method

  2023cites this paper
• Coadaptation between host genome and microbiome under long-term xenobiotic-induced selection

  2021cites this paper
• Immune and Nervous Systems Interaction in Endocrine Disruptors Toxicity: The Case of Atrazine

  2021cites this paper
• Changes in Microbiome Confer Multigenerational Host Resistance after Sub-toxic Pesticide Exposure.

  2020cites this paper
• The potential benefits of dietary β‐glucan against growth retardation, immunosuppression, oxidative stress and expression of related genes and susceptibility to Aeromonas hydrophila challenge in Oreochromis niloticus induced by herbicide pendimethalin

  2020cites this paper
• Effects of maternal exposure to extract of Trichilia catigua on antibody production in the offspring of Wistar rats

  2019cites this paper
• Glycyrrhizic acid modulates the atrazine-induced apoptosis in rabbit spleen

  2019cites this paper
• Long-term Immunotoxic Effects of Oral Prenatal and Neonatal Atrazine Exposure

  2019cites this paper
• Oral and dermal diflubenzuron exposure causes a hypothalamic-pituitary-thyroid (HPT) axis disturbance in the Mongolian racerunner (Eremias argus).

  2018cites this paper
• Immunotoxicology of Pesticides

  2018cites this paper
• Developmental Exposure to a Mixture of 23 Chemicals Associated With Unconventional Oil and Gas Operations Alters the Immune System of Mice

  2018cites this paper
• Therapeutic effects of acupuncture with MOK, a polyherbal medicine, on PTU-induced hypothyroidism in rats

  2018cites this paper
• Changes in gene expression following long-term in vitro exposure of Macaca mulatta trophoblast stem cells to biologically relevant levels of endocrine disruptors.

  2018cites this paper
• Environmental toxicology: Sensitive periods of development and neurodevelopmental disorders

  2017cites this paper
• Lack of immunotoxic effects of repeated exposure to atrazine associated with the adaptation of adrenal gland activation

  2017cites this paper
• The potential protective role of Akropower against Atrazine- induced humoral immunotoxicity in rabbits.

  2017cites this paper
• Effect of atrazine on immunocompetence of red-eared slider turtle(Trachemys scripta)

  2016cites this paper
• Gene expression profiles in testis of developing male Xenopus laevis damaged by chronic exposure of atrazine.

  2016cites this paper
• EFFECT OF ORAL ADMINISTRATION OF SUBLETHAL CONCENTRATION OF ATRAZINE ON THE HAEMATOLOGICAL PROFILE OF ALBINO RAT

  2016cites this paper
• Influence of Early-Life Environmental Exposures on Immune Function Across the Life Span

  2016cites this paper
• Contributions of nonhematopoietic cells and mediators to immune responses: implications for immunotoxicology.

  2015cites this paper
• Immune System Toxicity and Immunotoxicity Hazard Identification

  2015cites this paper
• A comprehensive review of pesticides and the immune dysregulation: mechanisms, evidence and consequences

  2015cites this paper
• Evaluation of a novel delayed-type hypersensitivity assay to Candida albicans in adult and neonatal rats

  2015cites this paper
• In vitro exposure to the herbicide atrazine inhibits T cell activation, proliferation, and cytokine production and significantly increases the frequency of Foxp3+ regulatory T cells.

  2015influential citation
• Developmental immunotoxicity of chemicals in rodents and its possible regulatory impact

  2015influential citation
• Chlorotriazines Do Not Activate the Aryl Hydrocarbon Receptor, the Oestrogen Receptor or the Thyroid Receptor in In Vitro Assays

  2014cites this paper
• Assessing multiple endpoints of atrazine ingestion on gravid northern watersnakes (Nerodia sipedon) and their offspring

  2014cites this paper
• Characterization of atrazine transport across nasal respiratory and olfactory mucosae

  2014cites this paper
• Negative effects of low dose atrazine exposure on the development of effective immunity to FV3 in Xenopus laevis.

  2014cites this paper
• Macrophages as targets of developmental immunotoxicity

  2014cites this paper
• Effect of Nrf2 on rat ovarian tissues against atrazine-induced anti-oxidative response.

  2014cites this paper
• Office of Environmental Health Hazard Assessment

  2013cites this paper
• Pesticide induced immunotoxicity in humans: a comprehensive review of the existing evidence.

  2013cites this paper
• Estimation of placental and lactational transfer and tissue distribution of atrazine and its main metabolites in rodent dams, fetuses, and neonates with physiologically based pharmacokinetic modeling.

  2013cites this paper
• Development and validation of a flow cytometric method to evaluate phagocytosis of pHrodo™ BioParticles® by granulocytes in multiple species.

  2013cites this paper
• Sub-acute exposure to the herbicide atrazine suppresses cell immune functions in adolescent mice.

  2013cites this paper
• Alkylpyridines and Miscellaneous Organic Nitrogen Compounds

  2012cites this paper
• Hematological and Immunological Changes Due to Short-term Oral Administration of Acephate

  2012cites this paper
• Tipping the Balance of Autism Risk: Potential Mechanisms Linking Pesticides and Autism

  2012cites this paper
• The Environment-Immune Route to Chronic Disease

  2012cites this paper
• Environmental toxicants and the developing immune system: a missing link in the global battle against infectious disease?

  2011cites this paper
• Effect of maternal exposure to ozone on reproductive outcome and immune, inflammatory, and allergic responses in the offspring

  2011cites this paper
• Demasculinization and feminization of male gonads by atrazine: consistent effects across vertebrate classes.

  2011cites this paper
• Immunotoxicity of Pesticides

  2010cites this paper
• Effects of prenatal diesel exhaust inhalation on pulmonary inflammation and development of specific immune responses.

  2010cites this paper
• The delayed type hypersensitivity assay using protein and xenogeneic cell antigens.

  2010cites this paper
• Biomarkers of Immunotoxicity

  2010cites this paper
• Immunotoxicology and Foods

  2010cites this paper
• Molecular, Cellular and Systemic Effects of Atrazine on the Xenopus Laevis Tadpole

  2010cites this paper
• Combined Exposure of Peripubertal Male Rats to the Endocrine-Disrupting Compound Atrazine and Power–Frequency Electromagnetic Fields Causes Degranulation of Cutaneous Mast Cells: A New Toxic Environmental Hazard?

  2010cites this paper
• Immunotoxicology of Pesticides and Chemotherapies

  2010cites this paper
• Atrazine Citation for Most Recent Iarc Review

  2010cites this paper
• Chronic exposure to high levels of atrazine alters expression of genes that regulate immune and growth-related functions in developing Xenopus laevis tadpoles.

  2009cites this paper
• In vitro Assessment of Arsenic Immune Toxicity using Human Cord Blood and Murine Bone Marrow Cells

  2009cites this paper
• The Herbicide Atrazine Activates Endocrine Gene Networks via Non-Steroidal NR5A Nuclear Receptors in Fish and Mammalian Cells

  2008cites this paper
• Developmental Immunotoxicity in Rodents

  2008cites this paper
• Developmental immunotoxicity of atrazine in rodents.

  2008cites this paper
• Potential for Early-Life Immune Insult Including Developmental Immunotoxicity in Autism and Autism Spectrum Disorders: Focus on Critical Windows of Immune Vulnerability

  2008cites this paper
• Atrazine binds to F1F0-ATP synthase and inhibits mitochondrial function in sperm.

  2008cites this paper
• Combined in utero and juvenile exposure of mice to arsenate and atrazine in drinking water modulates gene expression and clonogenicity of myeloid progenitors.

  2008cites this paper
• Immune function is not impaired in Sprague-Dawley rats exposed to dimethyltin dichloride (DMTC) during development or adulthood.

  2007cites this paper
• Methodologies for developmental immunotoxicity (DIT) testing.

  2007cites this paper
• In vitro atrazine exposure affects the phenotypic and functional maturation of dendritic cells.

  2007cites this paper
• Development of an immunochemical detection method for atrazine-induced albumin adducts.

  2007cites this paper
• Pilot Study of Sublethal Effects on Fish of Pesticides Currently Used and Proposed for Use on Maine Blueberries

  2007cites this paper
• Effects of low doses of atrazine on the neurobehavioural development of mice

  2007cites this paper
• Evidence of endocrine disruption in amphibians due to agricultural chemical exposure

  2007cites this paper
• Reproductive Disorders Associated with Pesticide Exposure

  2007cites this paper
• Perturbation of Organogenesis by the Herbicide Atrazine in the Amphibian Xenopus laevis

  2007cites this paper
• Effects of atrazine and iridovirus infection on survival and life‐history traits of the long‐toed salamander (Ambystoma macrodactylum)

  2006cites this paper
• Identification of a novel hemoglobin adduct in Sprague Dawley rats exposed to atrazine.

  2006cites this paper
• [The effect of propylthiouracil on function of phagocytic peripheral blood cells in persons with thyroid hyperfunction].

  2006cites this paper
• Immunomodulatory effects of maternal atrazine exposure on male Balb/c mice.

  2006influential citation
• Efficient testing strategies for evaluation of xenobiotics with neuroendocrine activity.

  2006cites this paper
• A Dose-Response Study of the Effects of Prenatal and Lactational Exposure to TCDD on the Immune Response to Influenza A Virus

  2006cites this paper
• New Developments in the Assessment of Developmental Immunotoxicology

  2005influential citation
• Reptiles: The Research Potential of an Overlooked Taxon in Immunotoxicology

  2005cites this paper
• Biomarkers of Immunotoxic Effects in the Context of Environmental Risk Assessment

  2005cites this paper
• Sustained Exposure to the Widely Used Herbicide Atrazine: Altered Function and Loss of Neurons in Brain Monoamine Systems

  2005cites this paper
• Sex-specific effects of neonatal exposures to low levels of cadmium through maternal milk on development and immune functions of juvenile and adult rats.

  2005cites this paper
• Oral exposure to atrazine modulates cell-mediated immune function and decreases host resistance to the B16F10 tumor model in female B6C3F1 mice.

  2005cites this paper
• Immunotoxic effects of short-term atrazine exposure in young male C57BL/6 mice.

  2005cites this paper
• Immune Responses in Sprague–Dawley Rats Exposed to Dibutyltin Dichloride in Drinking Water as Adults

  2005cites this paper