Progress in research on brain development and function of mice during weaning.

Wenjie Zhang,Yueling Zhang,Yuanjia Zheng,Mingxuan Zheng,Nannan Sun,Xiaoying Yang,Yong Gao

Published 2019 in Current protein and peptide science

ABSTRACT

Lactation is a critical phase for brain function development. New dietary experiences of mouse caused by weaning can regulate brain development and function, increase their response to food and environment,eventually give rise to corresponding behavioral changes. Changes in weaning time induce the alteration of brain tissues morphology and molecular characteristics, glial cell activity and behaviors in the offspring. In addition, it is also sensitive to the intervention of environment and drug during this period. That's to say, the study focused on brain development and function based on mouse weaning is critical to demonstrate the underlying pathogenesis of neuropsychiatric diseases and find new drug targets. This article mainly focuses on the developmental differentiation of the brain during lactation, especially during weaning in mice.

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