Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  1996-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/PNAS.93.20.11236PMID 8855339PMCID PMC1074519
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Isolation and Characterization of cDNAs Corresponding to Two Human Calcium, Calmodulin-regulated, 3′,5′-Cyclic Nucleotide Phosphodiesterases (*)

  1996cited by this paper
• Induction of Ca2+/calmodulin-stimulated cyclic AMP phosphodiesterase (PDE1) activity in Chinese hamster ovary cells (CHO) by phorbol 12-myristate 13-acetate and by the selective overexpression of protein kinase C isoforms.

  1995cited by this paper
• Inhibition of bcl-2 with antisense oligonucleotides induces apoptosis and increases the sensitivity of AML blasts to Ara-C.

  1995cited by this paper
• Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons.

  1995cited by this paper
• TGF-beta 1 and cyclic AMP promote apoptosis in resting human B lymphocytes.

  1995cited by this paper
• C-RAF-1 serine/threonine kinase is required in BCR/ABL-dependent and normal hematopoiesis.

  1995cited by this paper
• Growth inhibition of malignant CD5+B (B-1) cells by antisense IL-10 oligonucleotide.

  1995cited by this paper
• Alterations of c-myc expression by antisense oligodeoxynucleotides enhance the induction of apoptosis in HL-60 cells.

  1995cited by this paper
• Expression and regulation of human and rat phosphodiesterase type IV isogenes

  1994cited by this paper
• A novel cyclic GMP stimulated phosphodiesterase from rat brain.

  1994cited by this paper
• Multiple cyclic nucleotide phosphodiesterases.

  1994cited by this paper
• Antisense strategies in leukemia.

  1994cited by this paper
• Suppression of Philadelphia1 leukemia cell growth in mice by BCR-ABL antisense oligodeoxynucleotide.

  1994cited by this paper
• Modulation of rat thymocyte proliferative response through the inhibition of different cyclic nucleotide phosphodiesterase isoforms by means of selective inhibitors and cGMP-elevating agents.

  1993cited by this paper
• Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae.

  1993cited by this paper
• The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE IV) reveals a multigene family.

  1993cited by this paper
• Inhibition of c-fes expression by an antisense oligomer causes apoptosis of HL60 cells induced to granulocytic differentiation

  1993cited by this paper
• A new cyclic nucleotide phosphodiesterase isozyme expressed in the T-lymphocyte cell lines.

  1993cited by this paper
• Systemic Administration of a Phosphorothioate Oligonucleotide with a Sequence Complementary to p53 for Acute Myelogenous Leukemia and Myelodysplastic Syndrome: Initial Results of a Phase I Trial

  1993cited by this paper
• Role of the KIT protooncogene in normal and malignant human hematopoiesis.

  1992cited by this paper
• A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase.

  1992cited by this paper
• In vivo treatment of human leukemia in a scid mouse model with c-myb antisense oligodeoxynucleotides.

  1992cited by this paper
• Molecular cloning of cDNA encoding a "63"-kDa calmodulin-stimulated phosphodiesterase from bovine brain.

  1992cited by this paper
• Early increase in lymphocyte cyclic nucleotide phosphodiesterase activity upon mitogenic activation of human peripheral blood mononuclear cells

  1992cited by this paper
• Molecular cloning of DNA encoding a calmodulin-dependent phosphodiesterase enriched in striatum.

  1992cited by this paper
• Multiple high-affinity cAMP-phosphodiesterases in human T-lymphocytes.

  1991cited by this paper
• Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides.

  1991cited by this paper
• Programmed cell death (apoptosis) is induced rapidly and with positive cooperativity by activation of cyclic adenosine monophosphate‐kinase I in a myeloid leukemia cell line

  1991cited by this paper
• Normal and leukemic hematopoietic cells manifest differential sensitivity to inhibitory effects of c-myb antisense oligodeoxynucleotides: an in vitro study relevant to bone marrow purging.

  1991cited by this paper
• Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice.

  1991cited by this paper
• Induction of a calcium/calmodulin-dependent phosphodiesterase during phytohemagglutinin-stimulated lymphocyte mitogenesis.

  1990cited by this paper
• Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors.

  1990cited by this paper
• Agents that elevate cAMP stimulate DNA fragmentation in thymocytes.

  1990cited by this paper
• Adenosine receptor-mediated accumulation of cyclic AMP-induced T-lymphocyte death through internucleosomal DNA cleavage.

  1990cited by this paper
• High pressure liquid chromatography of cyclic nucleotide phosphodiesterase from purified human T-lymphocytes.

  1989cited by this paper
• The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response.

  1988cited by this paper
• Identification and characterization of a Ca2+-calmodulin-sensitive cyclic nucleotide phosphodiesterase in a human lymphoblastoid cell line.

  1987cited by this paper
• Cyclic nucleotide phosphodiesterase in normal and leukemic human lymphocytes and lymphoblasts.

  1984cited by this paper
• Activation of cyclic nucleotide phosphodiesterase from isolated human peripheral blood lymphocytes by mitogenic agents.

  1980cited by this paper
• Increased cyclic nucleotide phosphodiesterase activity associated with proliferation and cancer in human and murine lymphoid cells.

  1977cited by this paper
• Mechanism of lymphoma cell death induced by cyclic AMP.

  1975cited by this paper
• Induction of cytolysis of cultured lymphoma cells by adenosine 3':5'-cyclic monophosphate and the isolation of resistant variants.

  1973cited by this paper

• Genetics in a Danish Common Variable Immunodeficiency Cohort

  2025cites this paper
• Cyclic nucleotide phosphodiesterases as drug targets.

  2025cites this paper
• Discovery of novel selective phosphodiesterase‑1 inhibitors for the treatment of acute myelogenous leukemia.

  2024cites this paper
• Dissecting gastric cancer heterogeneity and exploring therapeutic strategies using bulk and single-cell transcriptomic analysis and experimental validation of tumor microenvironment and metabolic interplay

  2024cites this paper
• Advances in targeting Phosphodiesterase 1: From mechanisms to potential therapeutics.

  2023cites this paper
• Effect of Ca2+ binding states of calmodulin on the conformational dynamics and force responses of myosin lever arm.

  2022cites this paper
• PDE4 inhibitor eliminates breast cancer stem cells via noncanonical activation of mTOR

  2022cites this paper
• miR-5701 promoted apoptosis of clear cell renal cell carcinoma cells by targeting phosphodiesterase-1B

  2021cites this paper
• Role of phosphodiesterase 1 in the pathophysiology of diseases and potential therapeutic opportunities.

  2021cites this paper
• Binding Energy and Free Energy of Calcium Ion to Calmodulin EF-Hands with the Drude Polarizable Force Field

  2021cites this paper
• Role of Adiponectin in Cervical Cancer.

  2020cites this paper
• Role of water-bridged interactions in metal ion coupled protein allostery

  2019cites this paper
• Phosphodiesterases: CNS Functions and Diseases

  2017cites this paper
• Genetic Understanding of Stroke Treatment: Potential Role for Phosphodiesterase Inhibitors.

  2017cites this paper
• The role of adiponectin in obesity-associated female-specific carcinogenesis.

  2016cites this paper
• Carboxyamidotriazole: a novel inhibitor of both cAMP-phosphodiesterases and cGMP-phosphodiesterases.

  2015cites this paper
• Phosphodiesterase 9: insights from protein structure and role in therapeutics.

  2014cites this paper
• The Role of Cyclic Nucleotide Signaling Pathways in Cancer: Targets for Prevention and Treatment

  2014cites this paper
• Advances in targeting cyclic nucleotide phosphodiesterases

  2014cites this paper
• lymphocytic leukemia cells that is regulated by protein phosphatase 2A PDE4 inhibitors activate a mitochondrial apoptotic pathway in chronic

  2013cites this paper
• Design and Synthesis of 3,5‐Disubstituted‐1,2,4‐Oxadiazoles as Potent Inhibitors of Phosphodiesterase4B2

  2012cites this paper
• Rapid engraftment of human ALL in NOD/SCID mice involves deficient apoptosis signaling

  2012cites this paper
• Multifunctional Cationic Peptide Fractions from Flaxseed Protein Hydrolysates

  2012cites this paper
• Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis.

  2011cites this paper
• Early relapse in ALL is identified by time to leukemia in NOD/SCID mice and is characterized by a gene signature involving survival pathways.

  2011cites this paper
• Harnessing the clinical efficacy of phosphodiesterase 4 inhibitors in inflammatory lung diseases: dual-selective phosphodiesterase inhibitors and novel combination therapies.

  2011cites this paper
• cAMP/cGMP Dual-Specificity Phosphodiesterases

  2010cites this paper
• Identification of new subgroups and prognostic markers in pediatric B cell precursor acute lymphoblastic leukemia by gene expression profiling

  2010cites this paper
• Cyclic GMP phosphodiesterase as a novel molecular target for the prevention and treatment of breast cancer

  2010cites this paper
• Inhibition of PDE3, PDE4 and PDE7 potentiates glucocorticoid-induced apoptosis and overcomes glucocorticoid resistance in CEM T leukemic cells.

  2010cites this paper
• Ca2+/calmodulin‐stimulated PDE1 regulates the beta‐catenin/TCF signaling through PP2A B56 gamma subunit in proliferating vascular smooth muscle cells

  2010cites this paper
• Food protein-derived peptides as calmodulin inhibitors.

  2010cites this paper
• PHOSPHODIESTERASE INHIBITORS: THEIR ROLE AND IMPLICATIONS

  2009cites this paper
• Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G

  2009cites this paper
• Crosstalk between G-protein and Ca2+ pathways switches intracellular cAMP levels.

  2009cites this paper
• Characterization of phosphodiesterase 1 in human malignant melanoma cell lines.

  2009cites this paper
• Chronic Lymphocytic Leukemia and B and T Cells Differ in Their Response to Cyclic Nucleotide Phosphodiesterase Inhibitors1

  2009cites this paper
• Chronic haloperidol and clozapine produce different patterns of effects on phosphodiesterase-1B, -4B, and -10A expression in rat striatum.

  2008cites this paper
• ABCD of the phosphodiesterase family: interaction and differential activity in COPD

  2008cites this paper
• Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia

  2008cites this paper
• Modulação da expressão de genes de reparo do DNA em células humanas irradiadas com raios gama sob diferentes taxas de dose

  2007cites this paper
• Expression and regulation of mRNA for distinct isoforms of cAMP-specific PDE-4 in mitogen-stimulated and leukemic human lymphocytes

  2007cites this paper
• Induction of apoptosis by an inhibitor of cAMP-specific PDE in malignant murine carcinoma cells overexpressing PDE activity in comparison to their nonmalignant counterparts

  2007cites this paper
• Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95 2.

  2007cites this paper
• Organization and Ca2+ regulation of adenylyl cyclases in cAMP microdomains.

  2007cites this paper
• Cyclic nucleotide phosphodiesterases as targets for treatment of haematological malignancies.

  2006cites this paper
• Phosphodiesterase Isoforms‚Äî-An Annotated List

  2006cites this paper
• Phosphodiesterase 8 (PDE8) regulates chemotaxis of activated lymphocytes.

  2006cites this paper
• Development of an interleukin 2 receptor targeted gene therapy vehicle

  2006cites this paper
• Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterases

  2006cites this paper
• Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents.

  2006cites this paper
• Kinetics of the inhibition of calcium/calmodulin-dependent protein kinase II by pea protein-derived peptides.

  2005cites this paper
• Cyclic nucleotide phosphodiesterases (PDEs) in human osteoblastic cells; the effect of PDE inhibition on cAMP accumulation.

  2005influential citation
• Ca2+-calmodulin-dependent phosphodiesterase (PDE1): current perspectives.

  2005cites this paper
• Suppression of cyclic GMP‐specific phosphodiesterase 5 promotes apoptosis and inhibits growth in HT29 cells

  2005cites this paper
• Differential phosphodiesterase expression and cytosolic Ca2+ in human CNS tumour cells and in non‐malignant and malignant cells of rat origin

  2005cites this paper
• Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation.

  2005cites this paper
• A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases.

  2004cites this paper
• Systemic Immunoresponses in Mice after Repeated Exposure of Lungs to Spores of Streptomyces californicus

  2003cites this paper
• CHAPTER 194 – cAMP/cGMP Dual-Specificity Phosphodiesterases

  2003cites this paper
• PDE4 inhibitors activate a mitochondrial apoptotic pathway in chronic lymphocytic leukemia cells that is regulated by protein phosphatase 2A.

  2003cites this paper
• Apoptosis and Nitrative Stress Associated with Phosphodiesterase Inhibitor-Induced Mesenteric Vasculitis in Rats

  2003cites this paper
• Cyclic Nucleotide Phosphodiesterase 1C Promotes Human Arterial Smooth Muscle Cell Proliferation

  2002cites this paper
• SK&F 95654-Induced Acute Cardiovascular Toxicity in Sprague-Dawley Rats—Histopathologic, Electron Microscopic, and Immunohistochemical Studies

  2002influential citation
• Inhibition of PDE4 phosphodiesterase activity induces growth suppression, apoptosis, glucocorticoid sensitivity, p53, and p21(WAF1/CIP1) proteins in human acute lymphoblastic leukemia cells.

  2002cites this paper
• PDE4 cAMP-specific phosphodiesterases.

  2001cites this paper
• Regulatory roles of adenylate cyclase and cyclic nucleotide phosphodiesterases 1 and 4 in interleukin-13 production by activated human T cells.

  2001cites this paper
• Physical mapping and promoter structure of the murine cAMP-specific phosphodiesterase pde4a gene

  2000cites this paper
• The cAMP Signaling Pathway as a Therapeutic Target in Lymphoid Malignancies

  2000cites this paper
• Novel, potent calmodulin antagonists derived from an all-D hexapeptide combinatorial library that inhibit in vivo cell proliferation: activity and structural characterization.

  2000cites this paper
• Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin.

  2000cites this paper
• Cyclic Nucleotide Phosphodiesterase 3B Is a Downstream Target of Protein Kinase B and May Be Involved in Regulation of Effects of Protein Kinase B on Thymidine Incorporation in FDCP2 Cells1

  2000cites this paper
• Association between the expression of E1A oncogene and increased sensitivity to growth inhibition induced by sustained levels of cAMP in rat thyroid cells.

  2000cites this paper
• Apoptosis of eosinophils and lymphocytes in allergic inflammation.

  1999cites this paper
• Relationships between phosphatidic acid and cyclic nucleotide phosphodiesterases in activated human blood mononuclear cells

  1999cites this paper
• Aberrant expression of cAMP-response-element-binding protein ('CREB') induces apoptosis.

  1999cites this paper
• The molecular biology of cyclic nucleotide phosphodiesterases.

  1999cites this paper
• Cyclic nucleotide phosphodiesterases (PDE) 3 and 4 in normal, malignant, and HTLV-I transformed human lymphocytes.

  1999cites this paper
• Therapeutic potential of selective PDE inhibitors in asthma.

  1999cites this paper
• Cyclic Nucleotide Phosphodiesterases and Human Arterial Smooth Muscle Cell Proliferation

  1999cites this paper
• Phosphodiesterases in Asthma

  1999cites this paper
• Identification, quantitation, and cellular localization of PDE1 calmodulin-stimulated cyclic nucleotide phosphodiesterases.

  1998cites this paper
• Antisense inhibition of phosphodiesterase expression.

  1998cites this paper
• Type 4 cyclic adenosine monophosphate phosphodiesterase as a therapeutic target in chronic lymphocytic leukemia.

  1998cites this paper
• Cyclic AMP-specific phosphodiesterase inhibitor rolipram and RO-20-1724 promoted apoptosis in HL60 promyelocytic leukemic cells via cyclic AMP-independent mechanism.

  1998cites this paper
• 5 – Cyclic Nucleotide Regulation by Calmodulin

  1998cites this paper
• Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1.

  1997cites this paper
• In vitro differentiation of human monocytes to macrophages: change of PDE profile and its relationship to suppression of tumour necrosis factor‐α release by PDE inhibitors

  1997cites this paper
• Differential expression of cyclic nucleotide phosphodiesterase 3 and 4 activities in human T cell clones specific for myelin basic protein.

  1997cites this paper
• Rolipram, a phosphodiesterase-4-selective inhibitor, promotes the survival of cultured rat dopaminergic neurons.

  1997cites this paper