The Cytokine Network in Rheumatoid Arthritis: Definition of TNFα as a Therapeutic Target

mechanism or 'pathogenesis' of these diseases is becoming understood [1-6]. In this article I will review progress in elucidating important molecular events in the pathogenesis of RA. The work spans over a decade; during this time my group has investigated which of the local protein molecular mediator molecules, now generically termed 'cytokines' were highly expressed in the rheumatoid joints. We found a large collection of proinflammatory and anti-inflammatory cytokines in all samples (recently reviewed [7,8]). We then studied the dysregulation of cytokine expression in cultures of RA

• Publication year

  1996

• Venue

  Journal of the Royal College of Physicians of London

• Publication date

  1996-11-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/s0035-8819(25)00312-5PMID 8961212PMCID 5401498
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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