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Paired Box Gene 8 (Pax8) Is also an Immunomarker of B-Cell Lineage Which Can Be Source of Diagnostic Pitfalls

P. Gasparri,L. Roncati

Published 2019 in Chonnam medical journal

ABSTRACT

https://doi.org/10.4068/cmj.2019.55.1.70 C Chonnam Medical Journal, 2019 Chonnam Med J 2019;55:70-72 Corresponding Author: Luca Roncati Department of Medical and Surgical Sciences, Institute of Pathology, University Hospital of Modena, Policlinico, I-41124 Modena, Italy Tel: +390594224812, Fax: +390594224998, E-mail: emailmedical@gmail.com Article History: Received September 25, 2018 Accepted October 15, 2018 FIG. 1. Reactive lymphadenitis (A, hematoxylin & eosin; 4×): the germinal centers, the mantles and the marginal zone are brown-stained by immunohistochemistry for PAX8 (B, clone MRQ-50, Ventana; 5×) and PAX5 (C, clone SP34, Ventana; 5×) in an overlapping manner involving the B-cell nuclei. Germinal center-derived lymphoma (D, 4×), mantle cell lymphoma (E, 4×) and marginal zone lymphoma (F, 4×) are strongly labeled by PAX8 immunohistochemistry [chromogen: 3,3' diaminobenzidine tetrahydrochloride hydrate]. Paired Box Gene 8 (Pax8) Is also an Immunomarker of B-Cell Lineage Which Can Be Source of Diagnostic Pitfalls

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