Endogenous ferritin protects cells with iron-laden lysosomes against oxidative stress.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Free radical research

• Publication date

  1998-08-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1080/10715769800300121PMID 9790512
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nutrient Deprivation of Cultured Rat Hepatocytes Increases the Desferrioxamine-available Iron Pool and Augments the Sensitivity to Hydrogen Peroxide*

  1997cited by this paper
• On the cytoprotective role of ferritin in macrophages and its ability to enhance lysosomal stability.

  1997cited by this paper
• Oxidant-induced apoptosis: a consequence of lethal lysosomal leak?

  1997cited by this paper
• Newly delivered transferrin iron and oxidative cell injury

  1997cited by this paper
• Biology of the Lysosome

  1996cited by this paper
• Macrophage dysfunction following the phagocytosis of IgG‐coated erythrocytes: production of lipid peroxidation products

  1996cited by this paper
• The ferritins: molecular properties, iron storage function and cellular regulation.

  1996cited by this paper
• Macrophage erythrophagocytosis and iron exocytosis.

  1996cited by this paper
• Iron: The Essential Poison.

  1996cited by this paper
• Iron in human atheroma and LDL oxidation by macrophages following erythrophagocytosis.

  1996cited by this paper
• Effects of iron- and hemoglobin-loaded human monocyte-derived macrophages on oxidation and uptake of LDL.

  1995cited by this paper
• Lethal hydrogen peroxide toxicity involves lysosomal iron-catalyzed reactions with membrane damage.

  1995cited by this paper
• Cellular injury induced by oxidative stress is mediated through lysosomal damage.

  1995cited by this paper
• The endocytic pathway for H‐ferritin established in live MOLT‐4 cells by laser scanning confocal microscopy

  1994cited by this paper
• Pattern of iron storage in the rat heart following iron overloading with trimethylhexanoyl-ferrocene.

  1994cited by this paper
• Pathophysiology of iron toxicity.

  1994cited by this paper
• Visualization of iron in cultured macrophages: a cytochemical light and electron microscopic study using autometallography.

  1993cited by this paper
• Detection of H2O2 release from vascular endothelial cells.

  1993cited by this paper
• Iron sequestration by macrophages decreases the potential for extracellular hydroxyl radical formation.

  1993cited by this paper
• Modification of the in vitro cytotoxicity of hydrogen peroxide by iron complexes.

  1992cited by this paper
• On the limited ability of superoxide to release iron from ferritin.

  1990cited by this paper
• A cysteine-specific lysosomal transport system provides a major route for the delivery of thiol to human fibroblast lysosomes: possible role in supporting lysosomal proteolysis

  1990cited by this paper
• Identification of the ferroxidase centre in ferritin

  1989cited by this paper
• An experimental model system for leishmaniasis. An ultrastructural study on cultured macrophages exposed to Leishmania parasites and sodium stibogluconate.

  1988cited by this paper
• Free radical modification of low-density lipoprotein: mechanisms and biological consequences.

  1987cited by this paper
• Formation of hydroxyl radicals in the presence of ferritin and haemosiderin. Is haemosiderin formation a biological protective mechanism?

  1986cited by this paper
• Free radicals in biology and medicine

  1985cited by this paper
• Silver amplification of mercury sulfide and selenide: a histochemical method for light and electron microscopic localization of mercury in tissue.

  1985cited by this paper
• Effect of iron on the stability of macrophage lysosomes

  1983cited by this paper
• Macrophage radiosensitivity in culture as a function of exposure to ionic iron

  1983cited by this paper
• Localization of gold in biological tissue

  1981cited by this paper
• Studies on the Concentration and Intracellular Localization of Iron Proteins in Liver Biopsy Specimens from Patients with Iron Overload with Special Reference to their Role in Lysosomal Disruption

  1980cited by this paper
• Some physicochemical aspects of iron metabolism.

  1976cited by this paper
• Functions of lysosomes.

  1966cited by this paper

• Intracellular transformation and disposal mechanisms of magnetosomes in macrophages and cancer cells

  2023cites this paper
• Intracellular biotransformation and disposal mechanisms of magnetosomes in macrophages and cancer cells

  2023cites this paper
• Crosstalk Between Autophagy and Ferroptosis and Its Putative Role in Ischemic Stroke

  2020cites this paper
• The mechanistic role of chemically diverse metal ions in the induction of autophagy

  2017cites this paper
• Alzheimer’s disease: as it was in the beginning

  2017cites this paper
• The Repair of Skeletal Muscle Requires Iron Recycling through Macrophage Ferroportin

  2016cites this paper
• Time- and cell-type specific changes in iron, ferritin, and transferrin in the gerbil hippocampal CA1 region after transient forebrain ischemia

  2016cites this paper
• Iron-Mediated Lysosomal Membrane Permeabilization in Ethanol-Induced Hepatic Oxidative Damage and Apoptosis: Protective Effects of Quercetin

  2015cites this paper
• IRON METABOLISM AND AUTOPHAGY: A POORLY EXPLORED RELATIONSHIP THAT HAS IMPORTANT CONSEQUENCES FOR HEALTH AND DISEASE

  2015cites this paper
• Ferritin-stimulated lipid peroxidation, lysosomal leak, and macroautophagy promote lysosomal "metastability" in primary hepatocytes determining in vitro cell survival.

  2015cites this paper
• Oxidative stress-related damage of retinal pigment epithelial cells : possible protective properties of autophagocytosed iron-binding proteins

  2015cites this paper
• Oxidative Stress and the Homeodynamics of Iron Metabolism

  2015cites this paper
• Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells.

  2014cites this paper
• Biology of ferritin in mammals: an update on iron storage, oxidative damage and neurodegeneration

  2014cites this paper
• Lysosomal Iron, Iron Chelation, and Cell Death

  2013cites this paper
• Protective effects of lycopene on oxidative stress, proliferation and autophagy in iron supplementation rats.

  2013cites this paper
• Mobilization of Stored Iron in Mammals: A Review

  2013cites this paper
• Radiation protection following nuclear power accidents: a survey of putative mechanisms involved in the radioprotective actions of taurine during and after radiation exposure

  2012cites this paper
• Disrupted Iron Metabolism and Ensuing Oxidative Stress may Mediate Cognitive Dysfunction Induced by Chronic Cerebral Hypoperfusion

  2012cites this paper
• Cell sensitivity to oxidative stress is influenced by ferritin autophagy.

  2011cites this paper
• The role of lysosomes in iron metabolism and recycling.

  2011cites this paper
• Age-related lysosomal dysfunction: an unrecognized roadblock for cobalamin trafficking?

  2011cites this paper
• A comparative study of the antiproliferative activity of iron chelators PIH, SIH and their light-activated caged derivatives in skin cells

  2010cites this paper
• Protective effects of crude garlic by reducing iron-mediated oxidative stress, proliferation and autophagy in rats

  2010cites this paper
• Lysosomal Proteolysis Is the Primary Degradation Pathway for Cytosolic Ferritin and Cytosolic Ferritin Degradation Is Necessary for Iron Exit

  2010cites this paper
• Low pH does not modulate antioxidant status of diphenyl ditelluride but exacerbates Fe (II)-induced lipid peroxidation in liver preparation

  2009influential citation
• Molecular and biochemical changes of the cardiovascular system due to smoking exposure.

  2009cites this paper
• Elevated hepatic iron: a confounding factor in chronic hepatitis C.

  2009cites this paper
• Autophagy of HSP70 and chelation of lysosomal iron in a non-redox-active form

  2009cites this paper
• Towards the mechanism and comparative effect of diphenyl diselenide, diphenyl ditelluride and ebselen under various pathophysiological conditions in rat's kidney preparation.

  2009cites this paper
• Severe Hemorrhage Induced Expressions of Ferritin and Heme Oxygenase-1 in Leukocytes

  2009cites this paper
• Heat shock proteins: keys to healthy ageing?

  2009cites this paper
• The role of iron in rheumatoid arthritis

  2008cites this paper
• Lysosomes in iron metabolism, ageing and apoptosis

  2008influential citation
• expression in J774 macrophages Iron loading and erythrophagocytosis increase ferroportin 1 (FPN1)

  2008cites this paper
• Lysosomes and oxidative stress in aging and apoptosis.

  2008cites this paper
• Iron regulatory proteins increase neuronal vulnerability to hydrogen peroxide.

  2008cites this paper
• Venous thromboembolism prevention in cancer patients: the search for common antecedents

  2007cites this paper
• Autophagy, ageing and apoptosis: the role of oxidative stress and lysosomal iron.

  2007cites this paper
• Detection of Changes in Alveolar Macrophage Iron Status Induced by Select PM2.5-Associated Components Using Iron-Response Protein Binding Activity

  2007cites this paper
• Metallothionein protects against oxidative stress-induced lysosomal destabilization.

  2006cites this paper
• Release of iron from ferritin requires lysosomal activity.

  2006cites this paper
• Caspase-independent pathways of hair cell death induced by kanamycin in vivo

  2006cites this paper
• Lysosomal labilization

  2006cites this paper
• The rat Apg3p/Aut1p homolog is upregulated by ischemic preconditioning in the retina.

  2006cites this paper
• Deposition of iron and β‐amyloid plaques is associated with cortical cellular damage in rabbits fed with long‐term cholesterol‐enriched diets

  2006cites this paper
• The lysosomal-mitochondrial axis theory of postmitotic aging and cell death.

  2006cites this paper
• Hypercoagulability preceding cancer. Does hypercoagulability awaken dormant tumor cells in the host?

  2005cites this paper
• Iron-binding drugs targeted to lysosomes: a potential strategy to treat inflammatory lung disorders

  2005influential citation
• A model of lysosomal metabolism of dextran coated superparamagnetic iron oxide (SPIO) nanoparticles: implications for cellular magnetic resonance imaging

  2005cites this paper
• Iron, neuroinflammation, and Alzheimer's disease

  2005cites this paper
• Intracellular free iron and acidic pathways mediate TNF-induced death of rat hepatoma cells

  2005cites this paper
• Hypercoagulability preceding cancer

  2005cites this paper
• Hypercoagulability preceding cancer

  2005cites this paper
• Hypercoagulability preceding cancer. The iron hypothesis.

  2005cites this paper
• Distribution of ferritin in the rat hippocampus after kainate-induced neuronal injury

  2005cites this paper
• Iron, ferritin, and nutrition.

  2004cites this paper
• IRON ,F ERRITIN, AND NUTRITION

  2004cites this paper
• Intralysosomal iron: a major determinant of oxidant-induced cell death.

  2003cites this paper
• Iron overload and its association with cancer risk in humans: evidence for iron as a carcinogenic metal.

  2003cites this paper
• Reliability of serum iron, ferritin, nitrite, and association with risk of renal cancer in women.

  2003cites this paper
• Effects of hypoxia and nitric oxide on ferritin content of alveolar cells.

  2003cites this paper
• Molecular bases of cellular iron toxicity.

  2002cites this paper
• Serial Review: Iron and Cellular Redox Status Guest Editor: Mario Comporti MOLECULAR BASES OF CELLULAR IRON TOXICITY

  2002cites this paper
• Iron overload, oxidative stress, and axonal dystrophy in brain disorders.

  2001cites this paper
• SLC11A1 (formerly NRAMP1) and disease resistance

  2001cites this paper
• Novel cellular defenses against iron and oxidation: ferritin and autophagocytosis preserve lysosomal stability in airway epithelium

  2001cites this paper
• Lysosomal involvement in apoptosis

  2001cites this paper
• Natural-resistance-associated macrophage protein 1 is an H+/bivalent cation antiporter.

  2001cites this paper
• Alpha-lipoic acid and alpha-lipoamide prevent oxidant-induced lysosomal rupture and apoptosis.

  2001cites this paper
• -Lipoic acid and -lipoamide prevent oxidant-induced lysosomal rupture and apoptosis

  2001cites this paper
• Deficient ferritin immunoreactivity in tissues from niemann-pick type C patients: extension of findings to fetal tissues, H and L ferritin isoforms, but also one case of the rare Niemann-Pick C2 complementation group.

  2000cites this paper
• Hypothermia injury/cold‐induced apoptosis—evidence of an increase in chelatable iron causing oxidative injury in spite of low O2−/H2O2 formation

  2000cites this paper
• Protection against oxidant‐mediated lysosomal rupture: a new anti‐apoptotic activity of Bcl‐2?

  2000cites this paper
• Glucocorticoids and dietary iron regulate postnatal intestinal heavy and light ferritin expression in rats.

  2000cites this paper
• Distribution of ferritin and redox-active transition metals in normal and cataractous human lenses.

  2000cites this paper
• Apoptotic macrophage-derived foam cells of human atheromas are rich in iron and ferritin, suggesting iron-catalysed reactions to be involved in apoptosis.

  1999cites this paper
• Ceroid/lipofuscin-loaded human fibroblasts show increased susceptibility to oxidative stress.

  1999cites this paper
• β-Cells, Oxidative Stress, Lysosomal Stability, and Apoptotic/Necrotic Cell Death

  1999cites this paper
• Lysosomal involvement in apoptosis.

  1998cites this paper