C2-streptavidin mediates the delivery of biotin-conjugated tumor suppressor protein p53 into tumor cells.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Bioconjugate chemistry

• Publication date

  2013-03-25

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/bc300563cPMID 23506195
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• FK506‐binding protein 51 interacts with Clostridium botulinum C2 toxin and FK506 inhibits membrane translocation of the toxin in mammalian cells

  2012cited by this paper
• Somatostatin receptor-mediated tumor-targeting drug delivery using octreotide-PEG-deoxycholic acid conjugate-modified N-deoxycholic acid-O, N-hydroxyethylation chitosan micelles.

  2012cited by this paper
• Alginate/CaCO3 hybrid nanoparticles for efficient codelivery of antitumor gene and drug.

  2012cited by this paper
• Changing the Receptor Specificity of Anthrax Toxin

  2012cited by this paper
• Avidin-biotin technology in targeted therapy

  2010cited by this paper
• Biotinylated transferrin/avidin/biotinylated disulfide containing PEI bioconjugates mediated p53 gene delivery system for tumor targeted transfection.

  2010cited by this paper
• TP53 mutations in human cancers: origins, consequences, and clinical use.

  2010cited by this paper
• Genetically engineered clostridial C2 toxin as a novel delivery system for living mammalian cells.

  2010cited by this paper
• The C2-streptavidin delivery system promotes the uptake of biotinylated molecules in macrophages and T-leukemia cells

  2010cited by this paper
• Clostridium botulinum C2 toxin is internalized by clathrin‐ and Rho‐dependent mechanisms

  2010cited by this paper
• Efficacy of ligand-based targeting for the EGF system in cancer.

  2009cited by this paper
• Biotinylated glyco-functionalized quantum dots: synthesis, characterization, and cytotoxicity studies.

  2009cited by this paper
• Characterizing peptide-mediated DNA internalization in human cancer cells.

  2009cited by this paper
• Cyclophilin A facilitates translocation of the Clostridium botulinum C2 toxin across membranes of acidified endosomes into the cytosol of mammalian cells

  2009cited by this paper
• Binding and Internalization of Clostridium botulinum C2 Toxin

  2009cited by this paper
• Recombinant, refolded tetrameric p53 and gonadotropin-releasing hormone-p53 slow proliferation and induce apoptosis in p53-deficient cancer cells

  2008cited by this paper
• Phosphorylation of Fibroblast Growth Factor (FGF) Receptor 1 at Ser777 by p38 Mitogen-Activated Protein Kinase Regulates Translocation of Exogenous FGF1 to the Cytosol and Nucleus

  2008cited by this paper
• ADP-Ribosylation of Actin by the Clostridium botulinum C2 Toxin in Mammalian Cells Results in Delayed Caspase-Dependent Apoptotic Cell Death

  2008cited by this paper
• Binary actin-ADP-ribosylating toxins and their use as molecular Trojan horses for drug delivery into eukaryotic cells.

  2008cited by this paper
• Coping with stress: multiple ways to activate p53

  2007cited by this paper
• Quantitative analysis of the binding affinity of poly(ADP-ribose) to specific binding proteins as a function of chain length

  2007cited by this paper
• Structure and action of the binary C2 toxin from Clostridium botulinum.

  2006cited by this paper
• p53--a natural cancer killer: structural insights and therapeutic concepts.

  2006cited by this paper
• Antibody pretargeting advances cancer radioimmunodetection and radioimmunotherapy.

  2006cited by this paper
• Aptamer mediated siRNA delivery

  2006cited by this paper
• Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

  2006cited by this paper
• Genetically engineered avidins and streptavidins

  2006cited by this paper
• Biotinidase: its role in biotinidase deficiency and biotin metabolism.

  2005cited by this paper
• The Host Cell Chaperone Hsp90 Is Essential for Translocation of the Binary Clostridium botulinum C2 Toxin into the Cytosol*

  2003cited by this paper
• Purification of recombinant p53 from Sf9 insect cells.

  2003cited by this paper
• Development of p53 protein transduction therapy using membrane-permeable peptides and the application to oral cancer cells.

  2002cited by this paper
• Reduced antibody response to streptavidin through site‐directed mutagenesis

  2001cited by this paper
• Cellular Uptake of Clostridium botulinum C2 Toxin Requires Oligomerization and Acidification*

  2000cited by this paper
• p53 is associated with cellular microtubules and is transported to the nucleus by dynein

  2000cited by this paper
• The C Terminus of Component C2II ofClostridium botulinum C2 Toxin Is Essential for Receptor Binding

  2000cited by this paper
• Binding of Clostridium botulinum C2 Toxin to Asparagine-linked Complex and Hybrid Carbohydrates*

  2000cited by this paper
• Development of a binding assay for p53/HDM2 by using homogeneous time-resolved fluorescence.

  2000cited by this paper
• A Bipartite Nuclear Localization Signal Is Required for p53 Nuclear Import Regulated by a Carboxyl-terminal Domain*

  1999cited by this paper
• The N-Terminal Part of the Enzyme Component (C2I) of the BinaryClostridium botulinum C2 Toxin Interacts with the Binding Component C2II and Functions as a Carrier System for a Rho ADP-Ribosylating C3-Like Fusion Toxin

  1998cited by this paper
• Engineering subunit association of multisubunit proteins: a dimeric streptavidin.

  1997cited by this paper
• Central nervous system pharmacologic effect in conscious rats after intravenous injection of a biotinylated vasoactive intestinal peptide analog coupled to a blood-brain barrier drug delivery system.

  1996cited by this paper
• The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53.

  1993cited by this paper
• The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway.

  1992cited by this paper
• Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues.

  1992cited by this paper
• ADP-ribosylated actin caps the barbed ends of actin filaments.

  1988cited by this paper

• Molecular dosimetry of estragole and 1′-hydroxyestragole-induced DNA adduct formation, clastogenicity and cytotoxicity in human liver cell models

  2025cites this paper
• The DNA Repair Protein MGMT Protects against the Genotoxicity of N-Nitrosodimethylamine, but Not N-Nitrosodiethanolamine and N-Nitrosomethylaniline, in Human HepG2 Liver Cells with CYP2E1 Expression.

  2025cites this paper
• Metabolic glycan labelling with bio-orthogonal targeting and its potential in drug delivery.

  2024cites this paper
• The effects of ligand distribution and density on the targeting properties of dual-targeting folate/biotin Pluronic F127/Poly (lactic acid) polymersomes.

  2024cites this paper
• Poly(d,l-lactide-co-glycolide) Surface-Anchored Biotin-Loaded Irinotecan Nanoparticles for Active Targeting of Colon Cancer

  2024cites this paper
• Potency ranking of pyrrolizidine alkaloids in metabolically competent human liver cancer cells and primary human hepatocytes using a genotoxicity test battery

  2023cites this paper
• OCT1-dependent uptake of structurally diverse pyrrolizidine alkaloids in human liver cells is crucial for their genotoxic and cytotoxic effects

  2023cites this paper
• p53 triggers mitochondrial apoptosis following DNA damage-dependent replication stress by the hepatotoxin methyleugenol

  2022cites this paper
• Inhibition of calcium-triggered secretion by hydrocarbon-stapled peptides

  2022cites this paper
• Natural Merosesquiterpenes Activate the DNA Damage Response via DNA Strand Break Formation and Trigger Apoptotic Cell Death in p53-Wild-Type and Mutant Colorectal Cancer

  2021cites this paper
• The Mitochondrial Disruptor Devimistat (CPI-613) Synergizes with Genotoxic Anticancer Drugs in Colorectal Cancer Therapy in a Bim-Dependent Manner

  2021cites this paper
• Biotinylated chitosan macromolecule based nanosystems: A review from chemical design to biological targets.

  2021cites this paper
• In vitro and in vivo evaluation of biotin-mediated PEGylated nanostructured lipid as carrier of disulfiram coupled with copper ion

  2019cites this paper
• Transcription factors: Time to deliver.

  2018cites this paper
• Water-mediated green synthesis of PbS quantum dot and its glutathione and biotin conjugates for non-invasive live cell imaging

  2018cites this paper
• ENGINEERED CLOSTRIDIUM BOTULINUMTOXIN ADAPTED TO DELIVERMOLECULES INTO SELECTED CELLS

  2018cites this paper
• Biotin conjugated organic molecules and proteins for cancer therapy: A review.

  2018cites this paper
• The Binary Toxin CDT of Clostridium difficile as a Tool for Intracellular Delivery of Bacterial Glucosyltransferase Domains

  2018cites this paper
• [Targeted imaging ability of a biotinylated imaging probe Biotin-S-S-Rhodol for breast cancer cells in vitro].

  2017cites this paper
• AKT2 suppresses pro-survival autophagy triggered by DNA double-strand breaks in colorectal cancer cells

  2017cites this paper
• Designer nanoparticle: nanobiotechnology tool for cell biology

  2016cites this paper
• DNA damage response curtails detrimental replication stress and chromosomal instability induced by the dietary carcinogen PhIP

  2016cites this paper
• Retargeting the Clostridium botulinum C2 toxin to the neuronal cytosol

  2016cites this paper
• New potential peptide therapeutics perturbing CK1δ/α-tubulin interaction.

  2016cites this paper
• DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis.

  2015cites this paper
• Lipoic acid inhibits the DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction.

  2015cites this paper
• New Perspectives in Cancer Therapy: The Biotin-Antitumor Molecule

  2014cites this paper
• Modulare hybride Wirkstoff trans porter auf der Basis bakterieller Toxine

  2014cites this paper
• Channel-Forming Bacterial Toxins in Biosensing and Macromolecule Delivery

  2014cites this paper
• New Perspectives in Cancer Therapy: The Biotin-Antitumor MoleculeConjugates

  2014cites this paper
• Streptavidin–biotin technology: improvements and innovations in chemical and biological applications

  2013cites this paper
• A Cell-Permeable Fusion Protein Based on Clostridium botulinum C2 Toxin for Delivery of p53 Tumorsuppressor into Cancer Cells

  2013cites this paper