Cis-urocanic acid inhibits SAPK/JNK signaling pathway in UV-B exposed human corneal epithelial cells in vitro

H. Jauhonen,A. Kauppinen,T. Paimela,J. Laihia,L. Leino,A. Salminen,K. Kaarniranta

Published 2011 in Molecular Vision

ABSTRACT

Purpose Urocanic acid (UCA) is a major endogenous UV‐absorbing chromophore in the epidermis and it is also an efficacious immunosuppressant. The effects of cis‐UCA on UV‐B‐induced inflammatory and apoptotic responses in HCE‐2 cells, focusing on the nuclear factor kappa B (NF‐kappaB) and AP‐1 signalling pathways were studied.

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