A Molecular Toolkit to Visualize Native Protein Assemblies in the Context of Human Disease

We present a new molecular toolkit to investigate protein assemblies natively formed in the context of human disease. The system employs tunable microchips that can be decorated with switchable adaptor molecules to select for target proteins of interest and analyze them using molecular microscopy. Implementing our new streamlined microchip approach, we could directly visualize BRCA1 gene regulatory complexes from patient-derived cancer cells for the first time.

• Publication year

  2015

• Venue

  Scientific Reports

• Publication date

  2015-09-23

• Fields of study

  Biology, Medicine, Computer Science

• Identifiers
  DOI 10.1038/srep14440PMID 26395823PMCID 4585766
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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