Caveolin-1 Upregulation Contributes to c-Myc–Induced High-Grade Prostatic Intraepithelial Neoplasia and Prostate Cancer

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Molecular Cancer Research

• Publication date

  2011-12-05

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/1541-7786.MCR-11-0451PMID 22144662PMCID PMC3908884
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Integrative genomic profiling of human prostate cancer.

  2010cited by this paper
• Functional Analysis of Secreted Caveolin-1 in Mouse Models of Prostate Cancer Progression

  2009cited by this paper
• Caveolin-1 Promotes Autoregulatory, Akt-Mediated Induction of Cancer-Promoting Growth Factors in Prostate Cancer Cells

  2009influential reference
• N-myc is a novel regulator of PI3K-mediated VEGF expression in neuroblastoma

  2008cited by this paper
• Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis

  2008cited by this paper
• Tumor cell-secreted caveolin-1 has proangiogenic activities in prostate cancer.

  2008cited by this paper
• Caveolin-1 is required for the upregulation of fatty acid synthase (FASN), a tumor promoter, during prostate cancer progression

  2007cited by this paper
• Preoperative Serum Caveolin-1 as a Prognostic Marker for Recurrence in a Radical Prostatectomy Cohort

  2006cited by this paper
• Unopposed c‐MYC expression in benign prostatic epithelium causes a cancer phenotype

  2005cited by this paper
• Combined c‐Myc and caveolin‐1 expression in human prostate carcinoma predicts prostate carcinoma progression

  2005cited by this paper
• Caveolin-1 in oncogenic transformation, cancer, and metastasis.

  2005cited by this paper
• Caveolin-1 promotes tumor progression in an autochthonous mouse model of prostate cancer: genetic ablation of Cav-1 delays advanced prostate tumor development in tramp mice.

  2005cited by this paper
• Myc regulates VEGF production in B cells by stimulating initiation of VEGF mRNA translation

  2005cited by this paper
• Combination of prostate-specific antigen, clinical stage, and Gleason score to predict pathological stage of localized prostate cancer - A multi-institutional update

  2004cited by this paper
• Prostate Pathology of Genetically Engineered Mice: Definitions and Classification. The Consensus Report from the Bar Harbor Meeting of the Mouse Models of Human Cancer Consortium Prostate Pathology Committee

  2004cited by this paper
• Epidermal growth factor inhibition of c-Myc-mediated apoptosis through Akt and Erk involves Bcl-xL upregulation in mammary epithelial cells.

  2003cited by this paper
• Myc-driven murine prostate cancer shares molecular features with human prostate tumors.

  2003influential reference
• Caveolin-1 Maintains Activated Akt in Prostate CancerCells through Scaffolding Domain Binding Site Interactions with andInhibition of Serine/Threonine Protein Phosphatases PP1 andPP2A

  2003influential reference
• c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression.

  2002cited by this paper
• Regulation of Caveolin-1 Expression and Secretion by a Protein Kinase Cε Signaling Pathway in Human Prostate Cancer Cells*

  2002cited by this paper
• Caveolin-1 Interacts with Androgen Receptor

  2001cited by this paper
• Prostatic neoplasia in transgenic mice with prostate‐directed overexpression of the c‐myc oncoprotein

  2000cited by this paper
• Caveolin-1 is regulated by c-myc and suppresses c-myc-induced apoptosis

  2000cited by this paper
• Caveolin-1 expression in clinically confined human prostate cancer: a novel prognostic marker.

  1999cited by this paper
• Induction of mammary gland hyperplasia in transgenic mice over-expressing human Cdc25B

  1999cited by this paper
• Function of the c-Myc oncogenic transcription factor.

  1999cited by this paper
• c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism

  1999cited by this paper
• The opposing roles of the Akt and c-Myc signalling pathways in survival from CD95-mediated apoptosis

  1998cited by this paper
• A matter of life and cell death.

  1998cited by this paper
• Elevated expression of caveolin is associated with prostate and breast cancer.

  1998cited by this paper
• Suppression of caveolin expression induces androgen sensitivity in metastatic androgen-insensitive mouse prostate cancer cells

  1998cited by this paper
• Combination of prostate-specific antigen, clinical stage, and Gleason score to predict pathological stage of localized prostate cancer. A multi-institutional update.

  1997cited by this paper
• Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol.

  1997cited by this paper
• Caveolae, DIGs, and the dynamics of sphingolipid-cholesterol microdomains.

  1997cited by this paper
• Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

  1997cited by this paper
• Pathologic and clinical findings to predict tumor extent of nonpalpable (stage T1c) prostate cancer.

  1994cited by this paper
• The use of prostate specific antigen, clinical stage and Gleason score to predict pathological stage in men with localized prostate cancer.

  1993influential reference
• Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ.

  1989cited by this paper
• Printed in U.S.A. Copyright © 2000 by The Endocrine Society A Small Composite Probasin Promoter Confers High Levels of Prostate-Specific Gene Expression through Regulation by Androgens and Glucocorticoids in Vitro and in Vivo*

  year unknowncited by this paper

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  2026cites this paper
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  2025cites this paper
• Cooperativity of c-MYC with Krüppel-Like Factor 6 Splice Variant 1 induces phenotypic plasticity and promotes prostate cancer progression and metastasis

  2024cites this paper
• Implications of c-Myc in the pathogenesis and treatment efficacy of urological cancers.

  2024cites this paper
• Molecular Alterations Influencing the Prognostic Outcome in Small Pancreatic Cancer (≤2 cm)

  2024cites this paper
• Molecular pathogenesis, mechanism and therapy of Cav1 in prostate cancer

  2023cites this paper
• Advances in the study of regulators of ferroptosis in head and neck squamous cell carcinoma (Review)

  2023cites this paper
• Involvement of caveolin-1 in skin diseases

  2022cites this paper
• Molecular landscape of c-Myc signaling in prostate cancer: A roadmap to clinical translation.

  2022cites this paper
• Exploring YAP1-centered networks linking dysfunctional CFTR to epithelial–mesenchymal transition

  2022cites this paper
• Comparative Pathobiology of Canine and Human Prostate Cancer: State of the Art and Future Directions

  2022cites this paper
• Role of caveolin-1 in human organ function and disease: friend or foe?

  2021cites this paper
• Caveolin‐1 promotes cancer progression via inhibiting ferroptosis in head and neck squamous cell carcinoma

  2021cites this paper
• Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer

  2020cites this paper
• Caveola-forming proteins and prostate cancer

  2020cites this paper
• Identification of prognostic biomarker in predicting hepatocarcinogenesis from cirrhotic liver using protein and gene signatures.

  2019cites this paper
• Deregulation of E-cadherin, β-catenin, APC and Caveolin-1 expression occurs in canine prostate cancer and metastatic processes.

  2018cites this paper
• Active surveillance for prostate and thyroid cancers: evolution in clinical paradigms and lessons learned

  2018cites this paper
• Caveolin-1 and -2 regulate cell motility in castration-resistant prostate cancer

  2018cites this paper
• High-Grade Prostatic Intraepithelial Neoplasia

  2018cites this paper
• Baseline and longitudinal plasma caveolin‐1 level as a biomarker in active surveillance for early‐stage prostate cancer

  2018cites this paper
• Evaluation of c-Myc mRNA Expression Level in Benign Prostatic Hyperplasia and Prostatic Adenocarcinoma Tissues and Its Correlation with Clinicopathological Characteristics

  2018cites this paper
• Identification of spleen tyrosine kinase as a potential therapeutic target for esophageal squamous cell carcinoma using reverse phase protein arrays

  2018cites this paper
• Preventing clinical progression and need for treatment in patients on active surveillance for prostate cancer

  2017cites this paper
• β-Catenin Knockdown Affects Mitochondrial Biogenesis and Lipid Metabolism in Breast Cancer Cells

  2017cites this paper
• Knockdown of CAVEOLIN-1 Sensitizes Human Basal-Like Triple-Negative Breast Cancer Cells to Radiation

  2017cites this paper
• Versatile Functions of Caveolin-1 in Aging-related Diseases

  2017cites this paper
• The different functions and clinical significances of caveolin-1 in human adenocarcinoma and squamous cell carcinoma

  2017cites this paper
• Prognostic significance of epithelial/stromal caveolin-1 expression in prostatic hyperplasia, high grade prostatic intraepithelial hyperplasia and prostatic carcinoma and its correlation with microvessel density.

  2017cites this paper
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  2017cites this paper
• Caveolin-1 in the regulation of cell metabolism: a cancer perspective

  2016cites this paper
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  2016cites this paper
• Significant Association of Caveolin-1 and Caveolin-2 with Prostate Cancer Progression.

  2015cites this paper
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  2015cites this paper
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  2015cites this paper
• Up-regulation of AKAP13 and MAGT1 on cytoplasmic membrane in progressive hepatocellular carcinoma: a novel target for prognosis.

  2015cites this paper
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  2014cites this paper
• The predictive role of caveolin 1 and CD34 coexpression in anticipating occult carcinoma in prostatic needle core biopsy

  2014cites this paper
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  2014cites this paper
• Combined therapeutic effects of adenoviral vector-mediated GLIPR1 gene therapy and radiotherapy in prostate and bladder cancer models.

  2014cites this paper
• Caveolin and cavin family members: dual roles in cancer.

  2014cites this paper
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  2014cites this paper
• Oncogenes and Tumor Suppressors HSPC 111 Governs Breast Cancer Growth by Regulating Ribosomal Biogenesis

  2014cites this paper
• Value of caveolin-1 in cancer progression and prognosis: Emphasis on cancer-associated fibroblasts, human cancer cells and mechanism of caveolin-1 expression (Review)

  2014influential citation
• Quantum dots (QDs) restrain human cervical carcinoma HeLa cell proliferation through inhibition of the ROCK-c-Myc signaling.

  2013cites this paper
• Caveola-forming proteins caveolin-1 and PTRF in prostate cancer

  2013cites this paper
• Secreted caveolin-1 enhances periodontal inflammation by targeting gingival fibroblasts.

  2013cites this paper
• Prostate cancer progression after androgen deprivation therapy: mechanisms of castrate resistance and novel therapeutic approaches

  2013cites this paper
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  2013cites this paper