Information Transmission in a Neuron-Astrocyte Coupled Model

A coupled model containing two neurons and one astrocyte is constructed by integrating Hodgkin-Huxley neuronal model and Li-Rinzel calcium model. Based on this hybrid model, information transmission between neurons is studied numerically. Our results show that when the successive spikes are produced in neuron 1 (N1), the bursting-like spikes (BLSs) occur in two neurons simultaneously during the spikes being transferred to neuron 2 (N2). The existence of the astrocyte and a higher expression level of mGluRs facilitate the occurrence of BLSs, but the rate of occurrence is not sensitive to the parameters. Furthermore, time delay τ occurs during the information transmission, and τ is almost independent of the effect of the astrocyte. Additionally, we found that low coupling strength may result in the distortion of the information, and this distortion is also proven to be almost independent of the astrocyte.

• Publication year

  2013

• Venue

  PLoS ONE

• Publication date

  2013-11-29

• Fields of study

  Biology, Medicine, Physics, Computer Science

• Identifiers
  DOI 10.1371/journal.pone.0080324PMID 24312211PMCID 3843665
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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