IQGAPs: integrators of the cytoskeleton, cell adhesion machinery, and signaling networks.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Cell Motility and the Cytoskeleton

• Publication date

  2003-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/CM.10118PMID 12789660
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Localization of two IQGAPs in cultured cells and early embryos of Xenopus laevis.

  2003cited by this paper
• Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170.

  2002cited by this paper
• The Mechanism for Regulation of the F-actin Binding Activity of IQGAP1 by Calcium/Calmodulin* 210

  2002cited by this paper
• An IQGAP-related protein, encoded by AgCYK1, is required for septation in the filamentous fungus Ashbya gossypii.

  2002cited by this paper
• Iqg1p links spatial and secretion landmarks to polarity and cytokinesis

  2002cited by this paper
• The lamellipodium: where motility begins.

  2002cited by this paper
• IQGAP1 Is a Component of Cdc42 Signaling to the Cytoskeleton*

  2002cited by this paper
• Immunohistochemical analysis of IQGAP1 expression in human colorectal carcinomas: its overexpression in carcinomas and association with invasion fronts.

  2002cited by this paper
• Additional complexity on human chromosome 15q: identification of a set of newly recognized duplicons (LCR15) on 15q11-q13, 15q24, and 15q26.

  2001cited by this paper
• IQGAP1, a negative regulator of cell-cell adhesion, is upregulated by gene amplification at 15q26 in gastric cancer cell lines HSC39 and 40A

  2001cited by this paper
• The Effect of IQGAP1 on XenopusEmbryonic Ectoderm Requires Cdc42*

  2001cited by this paper
• Interactions of Cdc4p, a myosin light chain, with IQ-domain containing proteins in Schizosaccharomyces pombe.

  2001cited by this paper
• Recruitment of cortexillin into the cleavage furrow is controlled by Rac1 and IQGAP‐related proteins

  2001influential reference
• Cdc42 and Rac1 regulate the interaction of IQGAP1 with β-catenin

  2000cited by this paper
• An IQGAP-related gene is activated during tentacle formation in the simple metazoan Hydra

  2000cited by this paper
• Gastric Hyperplasia in Mice Lacking the Putative Cdc42 Effector IQGAP1

  2000cited by this paper
• A myosin light chain mediates the localization of the budding yeast IQGAP-like protein during contractile ring formation.

  2000cited by this paper
• IQGAP1 Integrates Ca2+/Calmodulin and Cdc42 Signaling*

  1999cited by this paper
• Cdc42 and Rac1 Regulate the Interaction of IQGAP1 with β-Catenin*

  1999cited by this paper
• IQGAP1 and Calmodulin Modulate E-cadherin Function*

  1999influential reference
• Rng2p, a protein required for cytokinesis in fission yeast, is a component of the actomyosin ring and the spindle pole body.

  1998cited by this paper
• Sequential Assembly of Myosin II, an IQGAP-like Protein, and Filamentous Actin to a Ring Structure Involved in Budding Yeast Cytokinesis

  1998cited by this paper
• Iqg1p, a Yeast Homologue of the Mammalian IQGAPs, Mediates Cdc42p Effects on the Actin Cytoskeleton

  1998cited by this paper
• The IQGAP-related protein DGAP1 interacts with Rac and is involved in the modulation of the F-actin cytoskeleton and control of cell motility.

  1998cited by this paper
• Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion.

  1998cited by this paper
• Dictyostelium IQGAP-related Protein Specifically Involved in the Completion of Cytokinesis

  1997cited by this paper
• Regulation of Cross-linking of Actin Filament by IQGAP1, a Target for Cdc42*

  1997cited by this paper
• An IQGAP-related protein controls actin-ring formation and cytokinesis in yeast.

  1997cited by this paper
• IQGAP1, a Rac- and Cdc42-binding Protein, Directly Binds and Cross-links Microfilaments

  1997influential reference
• Calmodulin Modulates the Interaction between IQGAP1 and Cdc42

  1997cited by this paper
• IQGAP1, a calmodulin‐binding protein with a rasGAP‐related domain, is a potential effector for cdc42Hs.

  1996cited by this paper
• The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases

  1996cited by this paper
• DGAP1, a homologue of rasGTPase activating proteins that controls growth, cytokinesis, and development in Dictyostelium discoideum

  1996cited by this paper
• Identification of a Putative Effector for Cdc42Hs with High Sequence Similarity to the RasGAP-related Protein IQGAP1 and a Cdc42Hs Binding Partner with Similarity to IQGAP2*

  1996influential reference
• Identification of IQGAP as a Putative Target for the Small GTPases, Cdc42 and Rac1*

  1996influential reference
• Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia.

  1995cited by this paper
• The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts

  1995cited by this paper
• Identification of a human rasGAP-related protein containing calmodulin-binding motifs.

  1994influential reference
• The small GTP-binding protein rac regulates growth factor-induced membrane ruffling.

  1992cited by this paper
• The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors.

  1992cited by this paper
• Differences in the organization of actin in the growth cones compared with the neurites of cultured neurons from chick embryos

  1983cited by this paper

• The IQGAP-related RasGAP IqgC regulates cell–substratum adhesion in Dictyostelium discoideum

  2024cites this paper
• The Antithetic Roles of IQGAP2 and IQGAP3 in Cancers

  2023cites this paper
• Depletion of IQ motif-containing GTPase activating protein 2 (IQGAP2) reduces hepatic glycogen and impairs insulin signaling

  2023cites this paper
• Effect of cadmium in the gonads of mussel (Mytilus coruscus): an ionomics and proteomics study

  2023cites this paper
• IQGAP1 Is a Phosphotyrosine-Regulated Scaffold for SH2-Containing Proteins

  2023cites this paper
• The role of cell division control protein 42 in tumor and non-tumor diseases: A systematic review

  2022cites this paper
• Protein molecular responses of field-collected oysters Crassostrea hongkongensis with greatly varying Cu and Zn body burdens.

  2021cites this paper
• Exploring the "other" subfamily of HECT E3-ligases for therapeutic intervention.

  2021cites this paper
• Cell Biology International

  2020cites this paper
• Purpuric drug eruptions induced by EGFR tyrosine kinase inhibitors are associated with IQGAP1‐mediated increase in vascular permeability

  2020cites this paper
• OTT_A_257729 8299..8311

  2020cites this paper
• IQGAP1 Negatively Regulates HIV-1 Gag Trafficking and Virion Production

  2020cites this paper
• IQGAP2 Inhibits Migration and Invasion of Gastric Cancer Cells via Elevating SHIP2 Phosphatase Activity

  2020cites this paper
• Ubiquitination of the scaffold protein IQGAP1 diminishes its interaction with and activation of the Rho GTPase CDC42

  2020cites this paper
• Proteomic insight of seminal plasma in spinal cord injured men submitted to oral probenecid treatment for improved motility

  2020cites this paper
• Integrative Analysis of the IQ Motif-Containing GTPase-Activating Protein Family Indicates That the IQGAP3-PIK3C2B Axis Promotes Invasion in Colon Cancer

  2020cites this paper
• Enhancement of Migration and Invasion of Gastric Cancer Cells by IQGAP3

  2020cites this paper
• The Correct Localization of Borealin in Midbody during Cytokinesis Depends on IQGAP1

  2020cites this paper
• Scaffolding protein IQ motif containing GTPase activating protein 2 (IQGAP2) regulates glycogen metabolism

  2020cites this paper
• Flightless anchors IQGAP1 and R-ras to mediate cell extension formation and matrix remodeling

  2020cites this paper
• Circular RNA sequencing indicates circ-IQGAP2 and circ-ZC3H6 as noninvasive biomarkers of primary Sjögren's syndrome.

  2020cites this paper
• Copper transporter ATP7A interacts with IQGAP1, a Rac1 binding scaffolding protein: role in PDGF-induced VSMC migration and vascular remodeling.

  2018cites this paper
• Novel Pathological Role of hnRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1) in Vascular Smooth Muscle Cell Function and Neointima Hyperplasia

  2017cites this paper
• HECTD1 controls the protein level of IQGAP1 to regulate the dynamics of adhesive structures

  2017cites this paper
• IQGAP1 Mediates Hcp1-Promoted Escherichia coli Meningitis by Stimulating the MAPK Pathway

  2017cites this paper
• BcIqg1, a fungal IQGAP homolog, interacts with NADPH oxidase, MAP kinase and calcium signaling proteins and regulates virulence and development in Botrytis cinerea

  2016cites this paper
• The role of IQGAP 1 in high glucose-induced apoptosis of podocytes and its possible mechanisms

  2016cites this paper
• On the Interaction Between Human IQGAP1 and Actin.

  2016cites this paper
• IQGAPs choreograph cellular signaling from the membrane to the nucleus.

  2015cites this paper
• Cytoskeleton Dynamics in Health and Disease: Role of Molecular Switches and Rheostats

  2015cites this paper
• The biology of IQGAP proteins: beyond the cytoskeleton

  2015cites this paper
• How actin/myosin crosstalks guide the adhesion, locomotion and polarization of cells.

  2015cites this paper
• Wnt signaling proteins associate with the nuclear pore complex: implications for cancer.

  2014cites this paper
• Involvement of IQGAP family proteins in the regulation of mammalian cell cytokinesis

  2014cites this paper
• Cancer Biology and the Nuclear Envelope

  2014cites this paper
• IQGAP1 promotes the phenotypic switch of vascular smooth muscle by myocardin pathway: a potential target for varicose vein.

  2014cites this paper
• Current status of NADPH oxidase research in cardiovascular pharmacology

  2013cites this paper
• IQGAP1 suppresses TβRII-mediated myofibroblastic activation and metastatic growth in liver.

  2013influential citation
• IQGAP1 interactome analysis by in vitro reconstitution and live cell 3‐color FRET microscopy

  2013cites this paper
• Helicobacter pylori‐induced alteration of epithelial cell signaling and polarity: A possible mechanism of gastric carcinoma etiology and disparity

  2013cites this paper
• IQGAP1 links PDGF receptor-β signal to focal adhesions involved in vascular smooth muscle cell migration: role in neointimal formation after vascular injury.

  2013cites this paper
• Analysis of differentially expressed genes in various stages of Duchenne muscular dystrophy by using a network view.

  2013cites this paper
• Tyrosine Phosphorylation of CD13 Regulates Inflammatory Cell–Cell Adhesion and Monocyte Trafficking

  2013cites this paper
• IQGAP 1 links PDGF receptor-signal to focal adhesions involved in vascular smooth muscle cell migration : role in neointimal formation after vascular injury

  2013cites this paper
• Molecular mechanisms of +TIPs in axonal extension

  2013cites this paper
• This information is current as Monocyte Trafficking Cell Adhesion and − Inflammatory Cell Tyrosine Phosphorylation of CD 13 Regulates

  2013cites this paper
• The scaffolding protein IQGAP1 co-localizes with actin at the cytoplasmic face of the nuclear envelope: implications for cytoskeletal regulation

  2012cites this paper
• IQGAP1 and its binding proteins control diverse biological functions.

  2012cites this paper
• Three-color FRET expands the ability to quantify the interactions of several proteins involved in actin filament nucleation

  2012cites this paper
• A conserved role of IQGAP1 in regulating TOR complex 1

  2012influential citation
• Thymosin beta 4 induces colon cancer cell migration and clinical metastasis via enhancing ILK/IQGAP1/Rac1 signal transduction pathway.

  2011cites this paper
• Multiple mechanisms underlie metastasis suppressor function of NM23-H1 in melanoma

  2011cites this paper
• Biomarkers of Glioma

  2011cites this paper
• Quantitative proteomic analysis of dexamethasone-induced effects on osteoblast differentiation, proliferation, and apoptosis in MC3T3-E1 cells using SILAC

  2011cites this paper
• NM23-H1 BLOCKS CELL MOTILITY INDEPENDENTLY OF ITS KNOWN ENZYMATIC ACTIVITIES IN A COHORT OF HUMAN MELANOMA CELLS

  2010cites this paper
• Morphological and proteomic analysis of early stage of osteoblast differentiation in osteoblastic progenitor cells.

  2010cites this paper
• A screen for phosphatidylinositol 3,4-bisphosphate and other 3-phosphoinositide effector proteins

  2010cites this paper
• An Emerging Role for IQGAP1 in Regulating Protein Traffic

  2010cites this paper
• IQGAP1 and vimentin are key regulator genes in naturally occurring hepatotumorigenesis induced by oxidative stress.

  2010cites this paper
• IQGAP1 Is Involved in Post-Ischemic Neovascularization by Regulating Angiogenesis and Macrophage Infiltration

  2010cites this paper
• Small G Proteins in Islet (cid:1) -Cell Function

  2010cites this paper
• Small G proteins in islet beta-cell function.

  2010cites this paper
• Novel Role of NADPH Oxidase in Angiogenesis and Stem/Progenitor Cell Function

  2009cites this paper
• ADP-ribosylation factor 6 regulates glioma cell invasion through the IQ-domain GTPase-activating protein 1-Rac1-mediated pathway.

  2009cites this paper
• IQGAP1 regulates cell proliferation through a novel CDC42-mTOR pathway

  2009cites this paper
• Downstream Targets and Intracellular Compartmentalization in Nox Signaling

  2009cites this paper
• The actin cytoskeleton in endothelial cell phenotypes.

  2009cites this paper
• IQGAPs in cancer: A family of scaffold proteins underlying tumorigenesis

  2009cites this paper
• Protein scaffolds in MAP kinase signalling.

  2009cites this paper
• Compartmentalization of Redox Signaling Through NADPH Oxidase–Derived ROS

  2009cites this paper
• Mediated Pathway − through the IQ-Domain GTPase-Activating Protein 1-Rac 1 ADP-Ribosylation Factor 6 Regulates Glioma Cell Invasion

  2009cites this paper
• Ultrastructural study of Rac1 and its effectors beneath the substratum-facing membrane.

  2008cites this paper
• Actin Pedestal Formation by Enteropathogenic Escherichia coli Is Regulated by IQGAP1, Calcium, and Calmodulin*

  2008cites this paper
• IQGAP1 Integrates Ca2+/Calmodulin and B-Raf Signaling*

  2008cites this paper
• IQGAP1 Stimulates Proliferation and Enhances Tumorigenesis of Human Breast Epithelial Cells*

  2008cites this paper
• A dual role for IQGAP1 in regulating exocytosis

  2008cites this paper
• Multiple proteins mediate IQGAP1-stimulated cell migration.

  2007cites this paper
• IQGAP1 regulates cell motility by linking growth factor signaling to actin assembly

  2007cites this paper
• IQGAP1 modulates activation of B-Raf

  2007cites this paper
• IQGAP1 Stimulates Actin Assembly through the N-Wasp-Arp2/3 Pathway*

  2007cites this paper
• IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth

  2007influential citation
• IQGAP1 binds Rap1 and modulates its activity.

  2007cites this paper
• VEGF Signaling Through NADPH Oxidase-Derived ROS

  2007cites this paper
• Localizing NADPH Oxidase–Derived ROS

  2006cites this paper
• Wnt signalling and the actin cytoskeleton

  2006cites this paper
• IQGAP1 Mediates VE-Cadherin–Based Cell–Cell Contacts and VEGF Signaling at Adherence Junctions Linked to Angiogenesis

  2006cites this paper
• IQGAP1 in cellular signaling: bridging the GAP.

  2006cites this paper
• Rho GTPase signaling in Dictyostelium discoideum: insights from the genome.

  2006cites this paper
• IQGAPs are differentially expressed and regulated in polarized gastric epithelial cells.

  2005cites this paper
• IQGAP1 Regulates Reactive Oxygen Species–Dependent Endothelial Cell Migration Through Interacting With Nox2

  2005cites this paper
• Self-association of IQGAP1

  2005cites this paper
• IQGAP 1 Regulates Reactive Oxygen Species – Dependent Endothelial Cell Migration Through Interacting With Nox 2

  2005cites this paper
• Untersuchungen zum Einsatz von small interfering RNAs gegen epidermal growth factor receptor in humanen Gliomzellen

  2004cites this paper
• Actin filament binding by a monomeric IQGAP1 fragment with a single calponin homology domain.

  2004cites this paper
• A new cytoskeletal connection for APC: linked to actin through IQGAP.

  2004cites this paper
• Involved in Reactive Oxygen Species IQGAP 1 , a Novel Vascular Endothelial Growth Factor Receptor Binding Protein

  2004cites this paper
• IQGAP1 Binds Rap1 and Modulates Its Activity*

  2004cites this paper
• IQGAP1, a Novel Vascular Endothelial Growth Factor Receptor Binding Protein, Is Involved in Reactive Oxygen Species–Dependent Endothelial Migration and Proliferation

  2004cites this paper