Nitrite anion: the key intermediate in alkyl nitrates degradative mechanism.

Alkyl nitrates are metabolized in vitro to yield nitric oxide, and thiol groups have long been considered necessary cofactors. Here, we report evidence that no reaction between thiols and alkyl nitrates takes place in vitro, but stronger reducing agents, such as iron(II) derivatives, are necessary; alkoxy radicals and nitrite anions are the reaction intermediates. The latter, in slightly acidic conditions, can nitrosate thiols to the corresponding S-nitrosothiols, the real NO releasers.

• Publication year

  2008

• Venue

  Journal of Medicinal Chemistry

• Publication date

  2008-04-29

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/jm701390cPMID 18442229
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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