Mineralocorticoid and Glucocorticoid Receptors Stimulate Epithelial Sodium Channel Activity in a Mouse Model of Cushing Syndrome

No abstract is available for this paper.

• Publication year

  2009

• Venue

  HYPERTENSION

• Publication date

  2009-10-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1161/HYPERTENSIONAHA.109.134973PMID 19635986
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Quantitative analysis of RU38486 (mifepristone) by HPLC triple quadrupole mass spectrometry.

  2009cited by this paper
• Conditional transgenic mice for studying the role of the glucocorticoid receptor in the renal collecting duct.

  2009cited by this paper
• Development of a highly sensitive ELISA for aldosterone in mouse urine: validation in physiological and pathophysiological states of aldosterone excess and depletion.

  2009cited by this paper
• Structural and functional changes in the kidneys of high-fat diet-induced obese mice.

  2009cited by this paper
• A switch in the mechanism of hypertension in the syndrome of apparent mineralocorticoid excess.

  2008cited by this paper
• Mouse model of type II Bartter's syndrome. I. Upregulation of thiazide-sensitive Na-Cl cotransport activity.

  2008cited by this paper
• ACTH-induced hypertension is dependent on the ouabain-binding site of the alpha2-Na+-K+-ATPase subunit.

  2008cited by this paper
• FOREBRAIN OSMOTIC REGULATION OF THE SYMPATHETIC NERVOUS SYSTEM

  2008cited by this paper
• Impairment of sodium balance in mice deficient in renal principal cell mineralocorticoid receptor.

  2007cited by this paper
• Maintained ENaC trafficking in aldosterone-infused rats during mineralocorticoid and glucocorticoid receptor blockade.

  2007cited by this paper
• Renal and endocrine changes in rats with inherited stress-induced arterial hypertension (ISIAH)

  2006cited by this paper
• Sgk kinases and their role in epithelial transport.

  2006cited by this paper
• Maxi-K channels contribute to urinary potassium excretion in the ROMK-deficient mouse model of Type II Bartter's syndrome and in adaptation to a high-K diet.

  2006cited by this paper
• Chronic High-Sodium Diet Increases Aortic Wall Endothelin-1 Expression in a Blood Pressure–Independent Fashion in Rats

  2006cited by this paper
• Glucocorticoids acutely increase cell surface Na+/H+ exchanger-3 (NHE3) by activation of NHE3 exocytosis.

  2005cited by this paper
• Mineralocorticoid versus glucocorticoid receptor occupancy mediating aldosterone-stimulated sodium transport in a novel renal cell line.

  2005cited by this paper
• Cortisol and the renal handling of electrolytes: role in glucocorticoid-induced hypertension and bone disease.

  2003cited by this paper
• Hyperfiltration and glomerulosclerosis.

  2003cited by this paper
• Altered expression of renal NHE3, TSC, BSC-1, and ENaC subunits in potassium-depleted rats.

  2002cited by this paper
• Effects of the Potassium Channel Blocker Barium on Sodium and Potassium Transport in the Rat Loop of Henle In Vivo

  2001cited by this paper
• Increased ACTH levels do not alter renal 11beta-hydroxysteroid dehydrogenase type 2 gene expression in the sheep.

  2001cited by this paper
• Sodium-potassium-adenosinetriphosphatase-dependent sodium transport in the kidney: hormonal control.

  2001cited by this paper
• Induction of the epithelial Na+ channel via glucocorticoids in mineralocorticoid receptor knockout mice

  2001cited by this paper
• Vasopressin V1A Receptor Antagonism Does Not Reverse Adrenocorticotrophin‐Induced Hypertension In The Rat

  2000cited by this paper
• Corticosteroid regulation of amiloride-sensitive sodium-channel subunit mRNA expression in mouse kidney.

  2000cited by this paper
• Adrenocorticotrophin-induced hypertension: effects of mineralocorticoid and glucocorticoid receptor antagonism.

  1999cited by this paper
• The site of action of furosemide.

  1998cited by this paper
• Human kidney 11 beta-hydroxysteroid dehydrogenase: regulation by adrenocorticotropin?

  1996cited by this paper
• Regulation of aldosterone synthase in human vascular endothelial cells by angiotensin II and adrenocorticotropin.

  1996cited by this paper
• Adrenal steroids stimulate thiazide-sensitive NaCl transport by rat renal distal tubules.

  1996cited by this paper
• Human kidney 11β-hydroxysteroid dehydrogenase: regulation by adrenocorticotropin?

  1996cited by this paper
• 11 beta-Hydroxysteroid dehydrogenase activity in Cushing's syndrome: explaining the mineralocorticoid excess state of the ectopic adrenocorticotropin syndrome.

  1995cited by this paper
• Evidence that high dose Cortisol-induced Na+ retention in man is not mediated by the mineralocorticoid receptor

  1995cited by this paper
• Corticotropin effects on blood pressure and fluid and electrolyte homeostasis in five strains of rats.

  1992cited by this paper
• Evidence that high dose cortisol-induced Na+ retention in man is not mediated by the mineralocorticoid receptor.

  1991cited by this paper
• ROLE OF THE SYMPATHETIC NERVOUS SYSTEM IN THE ONSET OF HYPERTENSION IN THE RAT: THE EFFECT OF 6‐OH‐DOPAMINE

  1991cited by this paper
• The mechanism of action of amiloride.

  1988cited by this paper
• Contribution of Vasopressin in Dexamethasone‐Induced Hypertension in Rats

  1988cited by this paper
• Control of sodium excretion in NE-ACTH hypertension: role of pressure natriuresis.

  1988cited by this paper
• Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated.

  1988cited by this paper
• Adrenocorticotropin and cortisol-induced changes in urinary sodium and potassium excretion in man: effects of spironolactone and RU486.

  1988cited by this paper
• Effects of ACTH and Cortisol Administration on Blood Pressure, Electrolyte Metabolism, Atrial Natriuretic Peptide and Renal Function in Normal Man

  1987cited by this paper
• Mechanisms of glucocorticoid-induced hypertension.

  1987cited by this paper
• Corticosteroids decrease glomerular angiotensin receptors.

  1987cited by this paper
• Multiple factors contribute to the pathogenesis of hypertension in Cushing's syndrome.

  1986cited by this paper
• Regulation by adrenal corticosteroids of sodium and potassium transport in loop of Henle and distal tubule of rat kidney.

  1986cited by this paper
• Glucocorticoid inhibition of mineralocorticoid action in the rat.

  1984cited by this paper
• Chronic effects of ACTH and cortisol excess on arterial pressure in normotensive and hypertensive dogs.

  1982cited by this paper
• Vitamin D metabolites and parathyroid hormone in Cushing's syndrome: relationship to calcium and phosphorus homeostasis.

  1982cited by this paper
• Response of several adrenal steroids to ACTH stimulation in essential hypertension.

  1977cited by this paper
• Letter: Non-specific enhancement of glomerular filtration by corticosteroids.

  1974cited by this paper
• Site of action of furosemide.

  1967cited by this paper

• Chronic ACTH Infusion Alters the Diurnal Rhythm of Sodium Excretion, Inducing Nondipping Blood Pressure and Salt-Sensitivity in Male Mice

  2025cites this paper
• Disrupted glucocorticoid receptor cell signalling causes a ciliogenesis defect in the fetal mouse renal tubule

  2025cites this paper
• A Meta-Analysis on Quantitative Sodium, Potassium and Chloride Metabolism in Horses and Ponies

  2025cites this paper
• Application of SGLT-2 inhibitors in non-diabetic CKD: mechanisms, efficacy, and safety

  2025cites this paper
• Glucocorticoid-induced acute diuresis in rats in relation to the reduced renal expression of sodium-dependent cotransporter genes.

  2024cites this paper
• Treatment goals in ANCA-associated vasculitis: defining success in a new era

  2024influential citation
• Salt Sensitivity: Causes, Consequences, and Recent Advances

  2023cites this paper
• Aldosterone: Renal Action and Physiological Effects.

  2023cites this paper
• Dietary Anions Control Potassium Excretion; it is More Than a Poorly Absorbable Anion Effect.

  2023cites this paper
• Laparoscopic adrenalectomy for adrenal tumors with endocrine activity: Perioperative management pathways for reduced complications and improved outcomes

  2023cites this paper
• Diagnosis and management of hypertension in patients with Cushing's syndrome: a position statement and consensus of the Working Group on Endocrine Hypertension of the European Society of Hypertension

  2022cites this paper
• Kidney injury and oxidative damage alleviation by Zingiber officinale: pharmacokinetics and protective approach in a combined murine model of osteoporosis

  2022cites this paper
• Kidney-Specific KO of the Circadian Clock Protein PER1 Alters Renal Sodium Handling, Aldosterone Levels, and Kidney/Adrenal Gene Expression.

  2022cites this paper
• High salt intake activates the hypothalamic–pituitary–adrenal axis, amplifies the stress response, and alters tissue glucocorticoid exposure in mice

  2022cites this paper
• Abnormal neonatal sodium handling in skin precedes hypertension in the SAME rat

  2021cites this paper
• Pituitary Macroadenoma: A Case of Balanced Deficiencies

  2021cites this paper
• Hypertension in Cushing’s Syndrome

  2020cites this paper
• Evaluation and Treatment of Patients With Hypercortisolism: A Review.

  2020cites this paper
• Secondary Hypertension

  2020cites this paper
• Cardiovascular risk and mortality in patients with active and treated hypercortisolism.

  2020cites this paper
• Hypertension and Adrenal Gland Disease

  2020cites this paper
• Mechanisms of Salt‐Sensitive Hypertension in a Mouse Model of ACTH‐Dependent Cushing Syndrome

  2019cites this paper
• The Pathophysiology and Treatment of Hypertension in Patients With Cushing's Syndrome

  2019cites this paper
• Lack of Renal Tubular Glucocorticoid Receptor Decreases the Thiazide-Sensitive Na+/Cl– Cotransporter NCC and Transiently Affects Sodium Handling

  2019cites this paper
• Hypertension and Cardiovascular Mortality in Patients with Cushing Syndrome.

  2019cites this paper
• Glucocorticoid receptor activation stimulates the sodium-chloride cotransporter and influences the diurnal rhythm of its phosphorylation

  2019cites this paper
• Edinburgh Research Explorer Glucocorticoid receptor activation stimulates the Na-Cl cotransporter and influences the diurnal rhythm of its phosphorylation

  2019cites this paper
• Remission of hypertension after surgical cure of Cushing's syndrome

  2019cites this paper
• Edinburgh Explorer The Evolution of Hypertension: old genes, new concepts

  2018cites this paper
• The renal and blood pressure response to low sodium diet in P2X4 receptor knockout mice

  2018cites this paper
• The Low-Renin Hypertension Phenotype: Genetics and the Role of the Mineralocorticoid Receptor

  2018cites this paper
• Increased Urinary Extracellular Vesicle Sodium Transporters in Cushing Syndrome With Hypertension

  2018cites this paper
• Renal and Blood Pressure Response to a High-Salt Diet in Mice With Reduced Global Expression of the Glucocorticoid Receptor

  2018cites this paper
• 11β-Hydroxysteroid Dehydrogenases and Hypertension in the Metabolic Syndrome

  2017cites this paper
• Effect of maternal renin-angiotensin-aldosterone system activation on social coping strategies and gene expression of oxytocin and vasopressin in the brain of rat offspring in adulthood.

  2017cites this paper
• Conditional Deletion of Hsd11b2 in the Brain Causes Salt Appetite and Hypertension

  2016cites this paper
• Edinburgh Research Explorer ER-stress and basement membrane defects combine to cause glomerular and tubular renal disease caused by Col4a1 mutations

  2016cites this paper
• ISN Forefronts Symposium 2015: The Evolution of Hypertension–Old Genes, New Concepts

  2016cites this paper
• ER stress and basement membrane defects combine to cause glomerular and tubular renal disease resulting from Col4a1 mutations in mice

  2016cites this paper
• Dexamethasone and insulin activate serum and glucocorticoid‐inducible kinase 1 (SGK1) via different molecular mechanisms in cortical collecting duct cells

  2016cites this paper
• A Pilot Study Exploring the Plasma Potassium Variation in Dogs Undergoing Steroid Therapy and Its Clinical Importance.

  2016cites this paper
• Metabolic consequences of modern immunosuppressive agents in solid organ transplantation

  2016cites this paper
• Glucocorticoids and the diurnal rhythm of NCC phosphorylation: implications for blood pressure control

  2016influential citation
• University of Dundee Dexamethasone and insulin activate serum and glucocorticoid-inducible kinase 1 ( SGK 1 ) via different molecular mechanisms in cortical collecting duct cells

  2016cites this paper
• The hypertension of Cushing's syndrome: controversies in the pathophysiology and focus on cardiovascular complications

  2015cites this paper
• Deciphering physiological role of the mechanosensitive TRPV4 channel in the distal nephron.

  2015cites this paper
• A Critical Review of Steroid Immunotherapy in Kidney Transplantation

  2015cites this paper
• The Molecular Basis of Renal Potassium Excretion

  2014cites this paper
• High-dose spironolactone changes renin and aldosterone levels in acutely decompensated heart failure

  2014cites this paper
• Mineralocorticoid receptor antagonism in acutely decompensated chronic heart failure.

  2014cites this paper
• Blood pressure and amiloride-sensitive sodium channels in vascular and renal cells

  2014cites this paper
• Glucocorticoids and renal Na+ transport: implications for hypertension and salt sensitivity

  2014cites this paper
• Chapter 49 – Regulation of K+ Excretion

  2013cites this paper
• An N-Ethyl-N-Nitrosourea Induced Corticotropin-Releasing Hormone Promoter Mutation Provides a Mouse Model for Endogenous Glucocorticoid Excess

  2013cites this paper
• Chronic Angiotensin II Infusion Drives Extensive Aldosterone-Independent Epithelial Na+ Channel Activation

  2013cites this paper
• Genetic dissection of sodium and potassium transport along the aldosterone‐sensitive distal nephron: Importance in the control of blood pressure and hypertension

  2013influential citation
• Glucocorticoid receptor is required for foetal heart maturation.

  2013cites this paper
• Drug updates and approvals: 2012 in review.

  2013cites this paper
• Role of 11βHSD2 in salt and water homeostasis

  2012cites this paper
• Contribution of glucocorticoid-mineralocorticoid receptor pathway on the obesity-related adipocyte dysfunction.

  2012cites this paper
• Failure to Downregulate the Epithelial Sodium Channel Causes Salt Sensitivity in Hsd11b2 Heterozygote Mice

  2012cites this paper
• Corticoadrenal activity in rat regulates betaine-homocysteine S-methyltransferase expression with opposite effects in liver and kidney.

  2012cites this paper
• Corticoadrenal activity regulates in rat betaine-homocysteine S-methyltransferase expression with opposites effects in liver and kidney

  2012cites this paper
• A urine-concentrating defect in 11β-hydroxysteroid dehydrogenase type 2 null mice.

  2012cites this paper
• CALL FOR PAPERS Integrative Aspects of Renal Endocrinology Regulation of epithelial Na channels by adrenal steroids: mineralocorticoid and glucocorticoid effects

  2011cites this paper
• Effects of mineralocorticoid receptor blockade on glucocorticoid-induced renal injury in adrenalectomized rats

  2011cites this paper
• The use of plasma aldosterone and urinary sodium to potassium ratio as translatable quantitative biomarkers of mineralocorticoid receptor antagonism

  2011cites this paper
• Hsd11b2 Haploinsufficiency in Mice Causes Salt Sensitivity of Blood Pressure

  2011cites this paper
• steroids: Mineralocorticoid and glucocorticoid effects

  2011cites this paper
• In vivo nuclear translocation of mineralocorticoid and glucocorticoid receptors in rat kidney: differential effect of corticosteroids along the distal tubule.

  2010cites this paper
• Dysregulation of epithelial Na+ absorption induced by inhibition of the kinases TORC1 and TORC2

  2010cites this paper
• The glucocorticoid receptor in the distal nephron is not necessary for the development or maintenance of dexamethasone-induced hypertension.

  2010cites this paper
• Cushing's syndrome, glucocorticoids and the kidney.

  2010cites this paper
• Transcriptional and physiological responses to chronic ACTH treatment by the mouse kidney

  2009influential citation
• A urine concentrating defect in 11β-Hydroxysteroid Dehydrogenase Type 2 knockout mice

  2009cites this paper
• Conditional Deletion of Hsd 11 b 2 in the Brain Causes Salt Appetite and Hypertension

  year unknowncites this paper