Skeletal muscle alterations in chronic heart failure: differential effects on quadriceps and diaphragm

N. Mangner,Bettina Weikert,T. Bowen,M. Sandri,Robert Höllriegel,S. Erbs,R. Hambrecht,G. Schuler,A. Linke,S. Gielen,V. Adams

Published 2015 in Journal of Cachexia, Sarcopenia and Muscle

ABSTRACT

Chronic heart failure (CHF) results in limb and respiratory muscle weakness, which contributes to exercise intolerance and increased morbidity and mortality, yet the molecular mechanisms remain poorly understood.

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