Domain architecture of the atypical Arf-family GTPase Arl13b involved in cilia formation.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  2008-08-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.bbrc.2008.06.001PMID 18554500
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2006cited by this paper
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  2006cited by this paper
• Intraflagellar transport and cilium-based signaling.

  2006cited by this paper
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• Bardet-Biedl syndrome: an emerging pathomechanism of intracellular transport

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  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2001cited by this paper
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