Melanocortin-4 receptor mutations paradoxically reduce preference for palatable foods

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2013-04-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.1304707110PMID 23569235PMCID PMC3637712
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Corrigendum: Melanocortin Receptor 4 Deficiency Affects Body Weight Regulation, Grooming Behavior, and Substrate Preference in the Rat

  2012cited by this paper
• Anhedonia requires MC4 receptor-mediated synaptic adaptations in nucleus accumbens

  2012cited by this paper
• Melanocortin Receptor 4 Deficiency Affects Body Weight Regulation, Grooming Behavior, and Substrate Preference in the Rat

  2011cited by this paper
• Characterization of the hyperphagic response to dietary fat in the MC4R knockout mouse.

  2011influential reference
• Melanocortin‐4 receptor expression in a vago‐vagal circuitry involved in postprandial functions

  2010cited by this paper
• Melanocortin activity in the amygdala controls appetite for dietary fat.

  2010influential reference
• Homeostatic and hedonic signals interact in the regulation of food intake.

  2009cited by this paper
• The melanocortin antagonist AgRP (83-132) increases appetitive responding for a fat, but not a carbohydrate, reinforcer.

  2008cited by this paper
• The amygdala, reward and emotion.

  2007cited by this paper
• Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans.

  2006cited by this paper
• Neuropeptide Y administration into the amygdala alters high fat food intake.

  2006cited by this paper
• Monogenic human obesity syndromes.

  2004cited by this paper
• Hyperphagia, not hypometabolism, causes early onset obesity in melanocortin-4 receptor knockout mice.

  2003cited by this paper
• Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene.

  2003influential reference
• The melanocortin receptor MCR4 controls fat consumption.

  2003cited by this paper
• Opioid receptor involvement in the effect of AgRP- (83-132) on food intake and food selection.

  2001cited by this paper
• Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat

  2001influential reference
• Disproportionate Inhibition of Feeding in Ay Mice by Certain Stressors: A Cautionary Note

  2000cited by this paper
• Macronutrient diet intake of the lethal yellow agouti (Ay/a) mouse.

  1999cited by this paper
• Amygdaloid-lesion hyperphagia: impaired response to caloric challenges and altered macronutrient selection.

  1998cited by this paper
• Amygdaloid-lesion hyperphagia: impaired response to caloric challenges and altered macronutrient selection.

  1998cited by this paper
• Targeted disruption of the melanocortin-4 receptor results in obesity in mice.

  1997influential reference
• Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors.

  1995cited by this paper

• Thalamic opioids from POMC satiety neurons switch on sugar appetite.

  2025cites this paper
• Understanding the desire for dessert.

  2025cites this paper
• The Melanocortin System: A Promising Target for the Development of New Antidepressant Drugs

  2023cites this paper
• Genetic Val66Met BDNF Variant Increases Hyperphagia on Fat-rich Diets in Mice.

  2023cites this paper
• CRTC1 deficiency, specifically in melanocortin‐4 receptor‐expressing cells, induces hyperphagia, obesity, and insulin resistance

  2022cites this paper
• Stimulation of Gs signaling in MC4R cells by DREADD increases energy expenditure, suppressing food intake, and increasing locomotor activity in mice.

  2022cites this paper
• Identification of the interactions between specific genetic polymorphisms and nutrient intake associated with general and abdominal obesity in middle-aged adults.

  2022cites this paper
• Identification of novel GPCR partners of the central melanocortin signaling

  2021cites this paper
• Deletion of the Feeding-Induced Hepatokine TSK Ameliorates the Melanocortin Obesity Syndrome

  2021cites this paper
• Monogenic human obesity syndromes.

  2021cites this paper
• MC4R as a Target for Pharmacotherapeutic Treatment of Obesity and Type 2 Diabetes

  2020cites this paper
• Appetite Regulation

  2020cites this paper
• Valproic acid administration exerts protective effects against stress-related anhedonia in rats.

  2020cites this paper
• VIPergic neurons of the infralimbic and prelimbic cortices control palatable food intake through separate cognitive pathways.

  2019cites this paper
• Genetic variants help define the role of the MC4R C-terminus in signaling and cell surface stability

  2018cites this paper
• Molecular Mechanisms of Reward and Aversion

  2017cites this paper
• Identification and Characterization of a Cardiomyopathy Syndrome Resulting from Loss of the Melanocortin 4 Receptor

  2017cites this paper
• The Role of the Melanocortin System in Metabolic Disease: New Developments and Advances

  2016cites this paper
• A Common Variant and the Transcript Levels of MC4R Gene Are Associated With Adiposity in Children: The IDEFICS Study.

  2016cites this paper
• Mechanisms and significance of brain glucose signaling in energy balance, glucose homeostasis, and food-induced reward.

  2016cites this paper
• The hunger genes: pathways to obesity.

  2015cites this paper
• Regulation of the mesocorticolimbic and mesostriatal dopamine systems by α-melanocyte stimulating hormone and agouti-related protein.

  2015cites this paper
• Mitigating or exacerbating effects of maternal-fetal programming of female mice through the food choice environment.

  2015cites this paper
• Moderate voluntary exercise attenuates the metabolic syndrome in melanocortin-4 receptor-deficient rats showing central dopaminergic dysregulation

  2015influential citation
• Inhibitory Effect of the Melanocortin Receptor Agonist Melanotan-II (MTII) on Feeding Depends on Dietary Fat Content and not Obesity in Rats on Free-Choice Diets

  2015cites this paper
• Association between melanocortin-4 receptor mutations and eating behaviors in obese patients: a case–control study

  2014cites this paper
• The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo.

  2014cites this paper
• Gene-Diet Interactions in Type 2 Diabetes

  2014cites this paper
• Association between MC4R rs17782313 polymorphism and overeating behaviors

  2014cites this paper
• Alterations to taste preference in mc4r haploinsufficiency manifest prior to dietary induced obesity and are accompanied by dendritic spine alterations to medium spiny neurons of the nucleus accumbens in adulthood

  2014cites this paper
• Elimination of Kalrn expression in POMC cells reduces anxiety-like behavior and contextual fear learning.

  2014cites this paper
• The expression of MC4Rs in D1R neurons regulates food intake and locomotor sensitization to cocaine

  2013cites this paper