Inhibitors of phosphatidylinositide 3-kinase: effects on reactive oxygen species and platelet aggregation.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Pharmacological Reports

• Publication date

  2007-03-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  PMID 17556803
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Platelet regulation by NO/cGMP signaling and NAD(P)H oxidase-generated ROS.

  2006cited by this paper
• A carbon monoxide-releasing molecule (CORM-3) attenuates lipopolysaccharide- and interferon-gamma-induced inflammation in microglia.

  2006cited by this paper
• Resveratrol, a phenolic antioxidant with effects on blood platelet functions

  2005cited by this paper
• Low dose aspirin depresses human platelet aggregation triggered by activating agents whose mechanisms involve arachidonic acid.

  2005cited by this paper
• Reactive Oxygen Species: Players in the Platelet Game

  2004cited by this paper
• Regulation of Endogenous Reactive Oxygen Species in Platelets Can Reverse Aggregation

  2004cited by this paper
• Free radicals in the physiological control of cell function.

  2002cited by this paper
• Reactive oxygen species and cell signaling: respiratory burst in macrophage signaling.

  2002cited by this paper
• Generation of reactive oxygen species in blood platelets

  2002cited by this paper
• The phosphoinositide 3-kinase pathway.

  2002cited by this paper
• Reactive oxygen species and cell signaling.

  2001cited by this paper
• Wortmannin inhibits platelet aggregation produced by interaction of gamma-aminobutyric acid and the calcium tonophore, A23187.

  2001cited by this paper
• PI3-kinase inhibition: a target for drug development?

  2000cited by this paper
• PI 3-kinase signalling in platelets: the significance of synergistic, autocrine stimulation.

  2000cited by this paper
• NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

  1999cited by this paper
• Anti-thrombotic and anti-inflammatory activities of protopine.

  1997cited by this paper
• Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

  1996cited by this paper
• Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation

  1995cited by this paper
• PI-3-kinase inhibitor Wortmannin blocks the insulin-like effects of growth hormone in isolated rat adipocytes.

  1994cited by this paper
• Modulation of platelet function by reactive oxygen metabolites.

  1994cited by this paper
• Quercetin inhibits Ca2+ uptake but not Ca2+ release by sarcoplasmic reticulum in skinned muscle fibers.

  1980cited by this paper

• Potential anti‐cancer activity of 7‐O‐pentyl quercetin: Efficient, membrane‐targeted kinase inhibition and pro‐oxidant effect

  2017cites this paper
• Hemorrhagic risk due to platelet dysfunction in myelodysplastic patients, correlations with anemia severity and iron overload

  2015cites this paper
• Anti-Inflammatory and Antiplatelet Activities of Plasma Are Conserved Across Twelve Mammalian Species

  2014cites this paper
• Multiple pathways are responsible for Anti-inflammatory and Cardiovascular activities of Hordeum vulgare L.

  2014cites this paper
• Pharmacological basis of the use of Acorus calamus L. in inflammatory diseases and underlying signal transduction pathways

  2014cites this paper
• POSSIBLE MECHANISM OF ACTION OF MENTHA ARVENSIS IN CARDIOVASCULAR DISEASES

  2014cites this paper
• Effect of Grewia asiatica fruit on glycemic index and phagocytosis tested in healthy human subjects.

  2013cites this paper
• ANTI-INFLAMMATORY AND ANTI-PLATELET ACTIVITIES OF AVENA SATIVA ARE MEDIATED THROUGH THE INHIBITION OF CYCLOOXYGENASE AND LIPOXYGENASE ENZYMES

  2013cites this paper
• Moderate Red Wine and Grape Juice Consumption Modulates the Hydrolysis of the Adenine Nucleotides and Decreases Platelet Aggregation in Streptozotocin-Induced Diabetic Rats

  2013cites this paper
• An Inhibition of p38 Mitogen Activated Protein Kinase Delays the Platelet Storage Lesion

  2013cites this paper
• Dual Inhibitory Activities of Adhatoda Vasica against Cyclooxygenase and Lipoxygenase

  2013cites this paper
• Grape Polyphenols Inhibit Akt/Mammalian Target of Rapamycin Signaling and Potentiate the Effects of Gefitinib in Breast Cancer

  2012cites this paper
• Effects of resveratrol and other wine polyphenols on vascular function: an update.

  2011cites this paper
• Exposure to ELF magnetic fields modulate redox related protein expression in mouse macrophages.

  2010cites this paper
• Radicales libres en el control de la agregación plaquetaria

  2010cites this paper
• Immunosuppressive Activity of Buxidin and E‐Buxenone from Buxus hyrcana

  2010cites this paper
• Stimulus-specific regulation of CD63 and CD203c membrane expression in human basophils by the flavonoid quercetin.

  2010cites this paper
• Insulin Is a Stronger Inducer of Insulin Resistance than Hyperglycemia in Mice with Type 1 Diabetes Mellitus (T1DM)*

  2009cites this paper
• Platelet aggregation, antiglycation, cytotoxic, phytotoxic and antimicrobial activities of extracts of Nepeta juncea

  2009cites this paper
• Antihypertensive effects of the flavonoid quercetin

  2009cites this paper
• Effect of chronic acamprosate treatment on voluntary alcohol intake and beta-endorphin plasma levels in rats selectively bred for high alcohol preference.

  2008cites this paper
• Parthenolide Inhibits Proliferation of Fibroblast-Like Synoviocytes In Vitro

  2008cites this paper
• A comparative study of the effects of quercetin and its glucuronide and sulfate metabolites on human neutrophil function in vitro.

  2008cites this paper
• Quercetin-5 ’-sulfonic acid sodium salt and morin-5 ’-sulfonic acid sodium salt as antidotes in the subacute cadmium intoxication in mice

  2007cites this paper