The Caenorhabditis elegans paxillin orthologue, PXL-1, is required for pharyngeal muscle contraction and for viability

Adam Warner,H. Qadota,G. Benian,A. W. Vogl,D. Moerman

Published 2011 in Molecular Biology of the Cell

ABSTRACT

Caenorhabditis elegans pxl-1 is the orthologue of vertebrate paxillin and is expressed in body wall and pharyngeal muscle. In body wall muscle PXL-1 localizes to dense bodies, M-lines, and adhesion plaques, and in pharyngeal muscle PXL-1 localizes to podosome-like actin attachment complexes. PXL-1 is required in the pharynx for muscle contraction and viability.

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