Normobaric hyperoxia markedly reduces brain damage and sensorimotor deficits following brief focal ischaemia.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Brain : a journal of neurology

• Publication date

  2016-03-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1093/brain/awv391PMID 26767570
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Future directions of acute ischaemic stroke therapy.

  2015cited by this paper
• Normobaric Hyperoxia Slows Blood–Brain Barrier Damage and Expands the Therapeutic Time Window for Tissue-Type Plasminogen Activator Treatment in Cerebral Ischemia

  2015influential reference
• Cortical Selective Neuronal Loss, Impaired Behavior, and Normal Magnetic Resonance Imaging in a New Rat Model of True Transient Ischemic Attacks

  2015influential reference
• Only Very Early Oxygen Therapy Attenuates Posthemorrhagic Edema Formation and Blood–Brain Barrier Disruption in Murine Intracerebral Hemorrhage

  2015cited by this paper
• What is the Optimal Duration of Middle-Cerebral Artery Occlusion Consistently Resulting in Isolated Cortical Selective Neuronal Loss in the Spontaneously Hypertensive Rat?

  2015cited by this paper
• Diffusion-Weighted Imaging and Diagnosis of Transient Ischemic Attack

  2014cited by this paper
• Mechanisms of neurovascular dysfunction in acute ischemic brain.

  2014cited by this paper
• Dodecafluoropentane Emulsion (DDFPe) Decreases Stroke Size and Improves Neurological Scores in a Permanent Occlusion Rat Stroke Model

  2014cited by this paper
• Persistent Cognitive Impairment After Transient Ischemic Attack

  2014cited by this paper
• The Stroke Oxygen Supplementation (S02S) study: A multi-centre, prospective, randomised, open, blinded-endpoint study of routine oxygen supplementation in the first 72 hours after stroke

  2014cited by this paper
• Selective Neuronal Loss in Ischemic Stroke and Cerebrovascular Disease

  2014influential reference
• Hyperbaric oxygen therapy for acute ischaemic stroke.

  2014cited by this paper
• Serial Montreal Cognitive Assessments Demonstrate Reversible Cognitive Impairment in Patients With Acute Transient Ischemic Attack and Minor Stroke

  2014cited by this paper
• Characterizing infarction and selective neuronal loss following temporary focal cerebral ischemia in the rat: a multi-modality imaging study.

  2013influential reference
• Perfluorocarbons Enhance a T2*-Based MRI Technique for Identifying the Penumbra in a Rat Model of Acute Ischemic Stroke

  2013cited by this paper
• Normobaric hyperoxia combined with minocycline provides greater neuroprotection than either alone in transient focal cerebral ischemia.

  2013cited by this paper
• A comparison of four PET tracers for brain hypoxia mapping in a rodent model of stroke.

  2013cited by this paper
• Is neural activation within the rescued penumbra impeded by selective neuronal loss?

  2013influential reference
• Effects of normobaric oxygen on the progression of focal cerebral ischemia in rats.

  2013cited by this paper
• The Stroke Oxygen Pilot Study: A Randomized Controlled Trial of the Effects of Routine Oxygen Supplementation Early after Acute Stroke—Effect on Key Outcomes at Six Months

  2013cited by this paper
• Synergetic Neuroprotection of Normobaric Oxygenation and Ethanol in Ischemic Stroke Through Improved Oxidative Mechanism

  2013cited by this paper
• Maternal hypertension during pregnancy modifies the response of the immature brain to hypoxia-ischemia: sequential MRI and behavioral investigations.

  2012cited by this paper
• Improvement of oxygen supply by an artificial carrier in combination with normobaric oxygenation decreases the volume of tissue hypoxia and tissue damage from transient focal cerebral ischemia.

  2012cited by this paper
• Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

  2012cited by this paper
• Evaluating effects of normobaric oxygen therapy in acute stroke with MRI-based predictive models

  2012cited by this paper
• A microPET study of the regional distribution of [11C]-PK11195 binding following temporary focal cerebral ischemia in the rat. Correlation with post mortem mapping of microglia activation

  2012influential reference
• Oxygen therapy improves energy metabolism in focal cerebral ischemia.

  2011influential reference
• Effect of Normobaric Oxygen Therapy in a Rat Model of Intracerebral Hemorrhage

  2011cited by this paper
• Single-subject statistical mapping of acute brain hypoxia in the rat following middle cerebral artery occlusion: a microPET study.

  2011cited by this paper
• New approaches to neuroprotective drug development.

  2011cited by this paper
• In Vivo Positron Emission Tomographic Imaging of Glial Responses to Amyloid-β and Tau Pathologies in Mouse Models of Alzheimer's Disease and Related Disorders

  2011cited by this paper
• Transient Cognitive Impairment in TIA and Minor Stroke

  2011cited by this paper
• Magnetic resonance imaging quantification of regional cerebral blood flow and cerebrovascular reactivity to carbon dioxide in normotensive and hypertensive rats

  2011cited by this paper
• Microembolism Versus Hemodynamic Impairment in Rosary-Like Deep Watershed Infarcts: A Combined Positron Emission Tomography and Transcranial Doppler Study

  2011cited by this paper
• Medical treatment in acute and long-term secondary prevention after transient ischaemic attack and ischaemic stroke.

  2011cited by this paper
• Positron emission tomography with 11C-flumazenil in the rat shows preservation of binding sites during the acute phase after 2 h-transient focal ischemia.

  2011cited by this paper
• Influence of 100% and 40% Oxygen on Penumbral Blood Flow, Oxygen Level, and T*2-Weighted MRI in a Rat Stroke Model

  2011influential reference
• Watershed Infarcts in Transient Ischemic Attack/Minor Stroke With ≥50% Carotid Stenosis: Hemodynamic or Embolic?

  2010cited by this paper
• Silent cortical neuronal damage in atherosclerotic disease of the major cerebral arteries

  2010influential reference
• Mapping selective neuronal loss and microglial activation in the salvaged neocortical penumbra in the rat

  2010influential reference
• Oxygen Therapy Reduces Secondary Hemorrhage after Thrombolysis in Thromboembolic Cerebral Ischemia

  2010cited by this paper
• Spontaneously hypertensive rat neuroanatomy: applications to pharmacological research.

  2010cited by this paper
• Differences in the Evolution of the Ischemic Penumbra in Stroke-Prone Spontaneously Hypertensive and Wistar-Kyoto Rats

  2009cited by this paper
• PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET.

  2009cited by this paper
• The adhesive removal test: a sensitive method to assess sensorimotor deficits in mice

  2009cited by this paper
• Normobaric Hyperoxia and Delayed tPA Treatment in a Rat Embolic Stroke Model

  2009influential reference
• Hemodynamic Compromise as a Cause of Internal Border-Zone Infarction and Cortical Neuronal Damage in Atherosclerotic Middle Cerebral Artery Disease

  2009influential reference
• Normobaric Hyperoxia Reduces the Neurovascular Complications Associated With Delayed Tissue Plasminogen Activator Treatment in a Rat Model of Focal Cerebral Ischemia

  2009cited by this paper
• Behavioral deficits after distal focal cerebral ischemia in mice: Usefulness of adhesive removal test.

  2009cited by this paper
• Combination therapy with normobaric oxygen (NBO) plus thrombolysis in experimental ischemic stroke

  2009influential reference
• Neuroprotection by Oxygen in Acute Transient Focal Cerebral Ischemia Is Dose Dependent and Shows Superiority of Hyperbaric Oxygenation

  2008cited by this paper
• Selective neuronal loss in rescued penumbra relates to initial hypoperfusion.

  2008influential reference
• Proposal for a Universal Definition of Cerebral Infarction

  2008cited by this paper
• The effect of oxygen therapy on brain damage and cerebral pO2 in transient focal cerebral ischemia in the rat

  2007influential reference
• Imaging of Brain Hypoxia in Permanent and Temporary Middle Cerebral Artery Occlusion in the Rat using 18F-Fluoromisonidazole and Positron Emission Tomography: A Pilot Study

  2007cited by this paper
• Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia.

  2007influential reference
• Delayed hyperbaric oxygenation is more effective than early prolonged normobaric hyperoxia in experimental focal cerebral ischemia.

  2007influential reference
• Magnetic Resonance Spectroscopy Study of Oxygen Therapy in Ischemic Stroke

  2007cited by this paper
• Selective neuronal damage and chronic hemodynamic cerebral ischemia

  2007influential reference
• Neurologic assessment of somatosensory dysfunction following an experimental rodent model of cerebral ischemia

  2007cited by this paper
• Normobaric Hyperoxia Delays Perfusion/Diffusion Mismatch Evolution, Reduces Infarct Volume, and Differentially Affects Neuronal Cell Death Pathways after Suture Middle Cerebral Artery Occlusion in Rats

  2007influential reference
• Intrinsic Activated Microglia Map to the Peri-infarct Zone in the Subacute Phase of Ischemic Stroke

  2006cited by this paper
• Long-Term Changes of Functional MRI–Based Brain Function, Behavioral Status, and Histopathology After Transient Focal Cerebral Ischemia in Rats

  2006cited by this paper
• An improved test of neurological dysfunction following transient focal cerebral ischemia in rats.

  2006cited by this paper
• Electron Paramagnetic Resonance-Guided Normobaric Hyperoxia Treatment Protects the Brain by Maintaining Penumbral Oxygenation in a Rat Model of Transient Focal Cerebral Ischemia

  2006influential reference
• Iomazenil–Single-Photon Emission Computed Tomography Reveals Selective Neuronal Loss in Magnetic Resonance-Defined Mismatch Areas

  2006influential reference
• Do transient ischemic attacks with diffusion-weighted imaging abnormalities correspond to brain infarctions?

  2006cited by this paper
• Rapid Reversible Changes in Dendritic Spine Structure In Vivo Gated by the Degree of Ischemia

  2005cited by this paper
• Early administration of a second-generation perfluorochemical decreases ischemic brain damage in a model of permanent middle cerebral artery occlusion in the rat

  2005cited by this paper
• Evolution of microglial activation in patients after ischemic stroke: a [11C](R)-PK11195 PET study

  2005cited by this paper
• A Pilot Study of Normobaric Oxygen Therapy in Acute Ischemic Stroke

  2005influential reference
• Normobaric hyperoxia extends the reperfusion window in focal cerebral ischemia

  2005influential reference
• Therapeutic Window for Use of Hyperbaric Oxygenation in Focal Transient Ischemia in Rats

  2004cited by this paper
• Interstitial pO2 in Ischemic Penumbra and Core are Differentially Affected following Transient Focal Cerebral Ischemia in Rats

  2004influential reference
• Neuropathological imaging: in vivo detection of glial activation as a measure of disease and adaptive change in the brain.

  2003cited by this paper
• Effects of Normobaric Hyperoxia in a Rat Model of Focal Cerebral Ischemia—Reperfusion

  2002influential reference
• Normobaric hyperoxia reduces MRI diffusion abnormalities and infarct size in experimental stroke

  2002influential reference
• Eubaric hyperoxemia and experimental cerebral infarction

  2002cited by this paper
• The assessment of postmortem brain volume; a comparison of stereological and planimetric methodologies

  1999cited by this paper
• Measurement of ischemia by changes in tissue oxygen, carbon dioxide, and pH.

  1999cited by this paper
• Parametric imaging of ligand-receptor binding in PET using a simplified reference region model.

  1997cited by this paper
• PK (‘peripheral benzodiazepine’) – binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK 11195 binding to activated microglia

  1997cited by this paper
• Brain Tissue Oxygen, Carbon Dioxide, and pH in Neurosurgical Patients at Risk for Ischemia

  1996cited by this paper
• Peripheral benzodiazepine receptors are colocalized with activated microglia following transient global forebrain ischemia in the rat

  1995cited by this paper
• Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation.

  1995cited by this paper
• Electron microscopic investigation of the cerebral cortex after cerebral ischemia and reperfusion in the gerbil.

  1992cited by this paper
• A New Model of Temporary Focal Neocortical Ischemia in the Rat

  1992cited by this paper
• Macrophage and Astrocyte Populations in Relation to [3H]PK 11195 Binding in Rat Cerebral Cortex following a Local Ischaemic Lesion

  1991cited by this paper
• The quantification of brain lesions with an omega 3 site ligand: a critical analysis of animal models of cerebral ischaemia and neurodegeneration.

  1990cited by this paper
• The Quantification of Cerebral Infarction following Focal Ischemia in the Rat: Influence of Strain, Arterial Pressure, Blood Glucose Concentration, and Age

  1988cited by this paper
• pH, K+, and PO2 of the Extracellular Space during Ischaemia of Primate Cerebral Cortex

  1987cited by this paper
• Blood Flow Through Cerebral Collateral Vessels in Hypertensive and Normotensive Rats

  1986cited by this paper
• Different susceptibilities to cerebral infarction in spontaneously hypertensive (SHR) and normotensive Sprague-Dawley rats.

  1986cited by this paper
• The Rat Brain in Stereotaxic Coordinates

  1983cited by this paper
• Tactile extinction: distinguishing between sensorimotor and motor asymmetries in rats with unilateral nigrostriatal damage.

  1982cited by this paper
• Changes in regional cortical tissue oxygen tension and cerebral blood flow during temporary middle cerebral artery occlusion in baboons.

  1976cited by this paper
• RESEARCH ARTICLE Open Access Stability of large diffusion/perfusion mismatch in anterior circulation strokes for 4 or more hours

  year unknowninfluential reference

• Fifty Years of Deciphering Stroke Pathophysiology.

  2025cites this paper
• Normobaric hyperoxia for intracerebral hemorrhage: a randomized clinical trial

  2025cites this paper
• Normobaric oxygen treatment in a depression-like model in male and female rats - Safety, behavioral benefits, and modulation of serotonin and inflammatory markers.

  2025cites this paper
• Normobaric hyperoxia alleviates complement C3‐mediated synaptic pruning and brain injury after intracerebral hemorrhage

  2024cites this paper
• Is Reperfusion Injury a Largely Intra-Ischemic Injury?

  2024cites this paper
• Neurological outcomes and mortality of hyperoxaemia in patients with acute brain injury: protocol for a systematic review and meta-analysis

  2024cites this paper
• The neuroprotective effects of normobaric oxygen therapy after stroke

  2024cites this paper
• Exploiting moderate hypoxia to benefit patients with brain disease: Molecular mechanisms and translational research in progress

  2023cites this paper
• Nuclear Factor Erythroid 2-Related Factor 2 is Essential for Low-Normobaric Oxygen Treatment-Mediated Blood-Brain Barrier Protection Following Ischemic Stroke

  2023cites this paper
• Normobaric Oxygen Therapy in Acute Stroke: A Systematic Review and Meta-Analysis

  2022cites this paper
• Potential mechanisms of acupuncture in enhancing cerebral perfusion of ischemic stroke

  2022cites this paper
• miR-383-5p Regulated by the Transcription Factor CTCF Affects Neuronal Impairment in Cerebral Ischemia by Mediating Deacetylase HDAC9 Activity

  2022cites this paper
• Cortical inflammation and brain signs of high-risk atherosclerosis in a non-human primate model

  2021cites this paper
• Oxygen Therapy in Headache Disorders: A Systematic Review

  2021cites this paper
• Adjuvant High-Flow Normobaric Oxygen After Mechanical Thrombectomy for Anterior Circulation Stroke: a Randomized Clinical Trial

  2021cites this paper
• Trans-nasal high-flow dehumidified air in acute migraine headaches: A randomized controlled trial

  2021cites this paper
• Normobaric oxygen may correct chronic cerebral ischemia‐mediated EEG anomalies

  2021cites this paper
• Stroke, Oxygen and Prehospital Care: A Commentary on Current Treatments and Opportunities for Improvement

  2021cites this paper
• Normobaric oxygen therapy attenuates hyperglycolysis in ischemic stroke

  2020cites this paper
• Advances in Normobaric Hyperoxia Brain Protection in Experimental Stroke

  2020cites this paper
• СОВРЕМЕННАЯ КОНЦЕПЦИЯ НЕЙРОПРОТЕКТИВНОЙ ТЕРАПИИ В ОСТРОМ ПЕРИОДЕ ИШЕМИЧЕСКОГО ИНСУЛЬТА

  2020cites this paper
• The modern concept of neuroprotective therapy in the acute period of ischemic stroke

  2020cites this paper
• Normobaric oxygen: a novel approach for treating chronic cerebral circulation insufficiency

  2019cites this paper
• Hiperoksemija u liječenju teške ozljede mozga

  2019cites this paper
• The neuroprotection effect of oxygen therapy: A systematic review and meta-analysis

  2018cites this paper
• Normobaric oxygen inhibits AQP4 and NHE1 expression in experimental focal ischemic stroke

  2018cites this paper
• Protecting the ischaemic penumbra as an adjunct to thrombectomy for acute stroke

  2018cites this paper
• Normobaric hyperoxia inhibits the progression of lung cancer by inducing apoptosis

  2018cites this paper
• Different Effects of Normobaric Oxygen in Normotensive Versus Hypertensive Rats After Focal Cerebral Ischemia

  2018cites this paper
• Relationships between selective neuronal loss and microglial activation after ischaemic stroke in man

  2018cites this paper
• Advance in neuroprotective therapy for ischemic stroke

  2018cites this paper
• Reconsidering Neuroprotection in the Reperfusion Era

  2017cites this paper
• Medical gases for stroke therapy: summary of progress 2015–2016

  2017cites this paper
• Effects of hyperoxia on 18F-fluoro-misonidazole brain uptake and tissue oxygen tension following middle cerebral artery occlusion in rodents: Pilot studies

  2017cites this paper
• Reconsidering Neuroprotection in the Reperfusion Era.

  2017cites this paper
• Molecular magnetic resonance imaging discloses endothelial activation after transient ischaemic attack

  2017cites this paper
• Reconsidering Neuroprotection in the Reperfusion Era

  2017cites this paper
• A New Paradigm in Protecting Ischemic Brain: Preserving the Neurovascular Unit Before Reperfusion

  2017cites this paper
• Dobutamine, a β1 Adrenoceptor Agonist, Increases Cerebral Oxygenation During Acute Anemia and Apneic Hypoxia

  2017cites this paper
• High-flow oxygen therapy for treatment of acute migraine: A randomized crossover trial

  2017cites this paper
• Normobaric hyperoxygenation: a potential neuroprotective therapy for acute ischemic stroke?

  2017cites this paper
• The underestimated effect of normobaric hyperoxia on cerebral blood flow and its relationship to neuroprotection.

  2016cites this paper
• Reply: The underestimated effect of normobaric hyperoxia on cerebral blood flow and its relationship to neuroprotection.

  2016cites this paper
• Reperfusion Injury : A Pharmacological Target After Successful Reperfusion ?

  year unknowncites this paper