Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Cell Science

• Publication date

  2008-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.035550PMID 18765564PMCID PMC2592597
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Toward a Comprehensive Atlas of the Physical Interactome of Saccharomyces cerevisiae*S

  2007cited by this paper
• Global landscape of protein complexes in the yeast Saccharomyces cerevisiae

  2006cited by this paper
• The life and death of translation elongation factor 2.

  2006cited by this paper
• Proteome survey reveals modularity of the yeast cell machinery

  2006cited by this paper
• Translation Elongation Factor 2 Anticodon Mimicry Domain Mutants Affect Fidelity and Diphtheria Toxin Resistance*

  2006influential reference
• Dph3, a Small Protein Required for Diphthamide Biosynthesis, Is Essential in Mouse Development

  2006cited by this paper
• Exotoxin A–eEF2 complex structure indicates ADP ribosylation by ribosome mimicry

  2005cited by this paper
• Gene trap mutagenesis-based forward genetic approach reveals that the tumor suppressor OVCA1 is a component of the biosynthetic pathway of diphthamide on elongation factor-2

  2005cited by this paper
• Gene Trap Mutagenesis-based Forward Genetic Approach Reveals That the Tumor Suppressor OVCA1 Is a Component of the Biosynthetic Pathway of Diphthamide on Elongation Factor 2*

  2005cited by this paper
• The Kluyveromyces lactis γ-toxin targets tRNA anticodons

  2005cited by this paper
• An early step in wobble uridine tRNA modification requires the Elongator complex.

  2005cited by this paper
• The Kluyveromyces lactis gamma-toxin targets tRNA anticodons.

  2005cited by this paper
• Identification of the Proteins Required for Biosynthesis of Diphthamide, the Target of Bacterial ADP-Ribosylating Toxins on Translation Elongation Factor 2

  2004influential reference
• Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation

  2004cited by this paper
• Ovca1 regulates cell proliferation, embryonic development, and tumorigenesis.

  2004influential reference
• The J‐protein family: modulating protein assembly, disassembly and translocation

  2004cited by this paper
• Elongator's toxin‐target (TOT) function is nuclear localization sequence dependent and suppressed by post‐translational modification

  2003cited by this paper
• Retroviral insertional mutagenesis identifies a small protein required for synthesis of diphthamide, the target of bacterial ADP-ribosylating toxins.

  2003influential reference
• Expression cloning

  2001cited by this paper
• Understanding the mode of action of diphtheria toxin: a perspective on progress during the 20th century.

  2001cited by this paper
• Cloning, structure, and expression of the mouse Ovca1 gene.

  2001cited by this paper
• Cloning and characterization of a new soluble murine J-domain protein that stimulates BiP, Hsc70 and DnaK ATPase activity with different efficiencies.

  2001cited by this paper
• A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse

  2000cited by this paper
• Interactions of elongation factor 2 with the cytoskeleton and interference with DNase I binding to actin.

  1998cited by this paper
• The reticulocalbin gene maps to the WAGR region in human and to the Small eye Harwell deletion in mouse.

  1997cited by this paper
• Interactions of eukaryotic elongation factor 2 with actin: A possible link between protein synthetic machinery and cytoskeleton

  1994cited by this paper
• Expression cloning of a diphtheria toxin receptor: identity with a heparin-binding EGF-like growth factor precursor.

  1992cited by this paper
• DPH5, a methyltransferase gene required for diphthamide biosynthesis in Saccharomyces cerevisiae

  1992cited by this paper
• In Vitro Biosynthesis of

  1991influential reference
• Some of eukaryotic elongation factor 2 is colocalized with actin microfilament bundles in mouse embryo fibroblasts.

  1991cited by this paper
• Mouse Small eye results from mutations in a paired-like homeobox-containing gene

  1991cited by this paper
• Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase.

  1991cited by this paper
• Requirement of specific receptors for efficient translocation of diphtheria toxin A fragment across the plasma membrane.

  1988cited by this paper
• Diphtheria toxin-resistant mutants of Saccharomyces cerevisiae

  1985cited by this paper
• In vitro biosynthesis of diphthamide, studied with mutant Chinese hamster ovary cells resistant to diphtheria toxin

  1984cited by this paper
• Occurrence of diphthamide in archaebacteria

  1983cited by this paper
• Posttranslational modification of elongation factor 2 in diphtheria-toxin-resistant mutants of CHO-K1 cells.

  1980cited by this paper
• ADP-ribosylation of elongation factor 2 by diphtheria toxin. Isolation and properties of the novel ribosyl-amino acid and its hydrolysis products.

  1980cited by this paper
• Characterization of the diphtheria toxin-resistance system in Chinese hamster ovary cells

  1979cited by this paper
• Elongation factor 2. Amino acid sequence at the site of adenosine diphosphate ribosylation.

  1974cited by this paper

• Genome-wide screening in human embryonic stem cells identifies genes and pathways involved in the p53 pathway

  2025cites this paper
• Diphthamide synthesis is linked to the eEF2‐client chaperone machinery

  2025cites this paper
• DNAJC24 suppresses breast cancer malignancy and serves as a prognostic biomarker

  2025cites this paper
• Arabidopsis Dph4 is an Hsp70 Cochaperone with Iron-Binding Properties

  2024cites this paper
• Diphthamide formation in Arabidopsis requires DPH1-interacting DPH2 for light and oxidative stress resistance

  2024cites this paper
• Hsp90 and cochaperones have two genetically distinct roles in regulating eEF2 function

  2024cites this paper
• A comprehensive characterization of cell-free RNA in spent blastocyst medium and quality prediction for blastocyst.

  2023cites this paper
• DPH1 Gene Mutations Identify a Candidate SAM Pocket in Radical Enzyme Dph1•Dph2 for Diphthamide Synthesis on EF2

  2023cites this paper
• eEF2 diphthamide modification restrains spurious frameshifting to maintain translational fidelity.

  2023cites this paper
• Diphthamide - a conserved modification of eEF2 with clinical relevance.

  2023cites this paper
• Context‐specific roles of diphthamide deficiency in hepatocellular carcinogenesis

  2022cites this paper
• LncRNA-mediated effects of vitrification temperatures and cryoprotectant concentrations on bovine oocyte development following vitrification at the GV stage.

  2022cites this paper
• Translational fidelity and growth of Arabidopsis require stress-sensitive diphthamide biosynthesis

  2022cites this paper
• The Astonishing Large Family of HSP40/DnaJ Proteins Existing in Leishmania

  2022cites this paper
• Diphthamide promotes TOR signaling by increasing the translation of proteins in the TORC1 pathway

  2021cites this paper
• Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

  2021cites this paper
• Immunotoxins: From Design to Clinical Application

  2021cites this paper
• Diagnosis and treatment of hairy cell leukemia as the COVID-19 pandemic continues

  2021cites this paper
• Iron in Translation: From the Beginning to the End

  2021cites this paper
• Identification of the transcription factor Miz1 as an essential regulator of diphthamide biosynthesis using a CRISPR-mediated genome-wide screen

  2020cites this paper
• Development of Recombinant Immunotoxins for Hairy Cell Leukemia

  2020cites this paper
• A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation

  2020cites this paper
• Diphthamide

  2020cites this paper
• Neuroinfections and Neglected Tropical Diseases (NTD)

  2020cites this paper
• The role of decreasing protein synthesis in delaying ageing : emphasis on translation accuracy

  2019cites this paper
• Translation Elongation and Recoding in Eukaryotes.

  2018cites this paper
• Roles of Elongator Dependent tRNA Modification Pathways in Neurodegeneration and Cancer

  2018cites this paper
• The tumor suppressor OVCA1 is a short half-life protein degraded by the ubiquitin-proteasome pathway

  2018cites this paper
• Importance of diphthamide modified EF2 for translational accuracy and competitive cell growth in yeast

  2018cites this paper
• Complex Evolutionary History of Translation Elongation Factor 2 and Diphthamide Biosynthesis in Archaea and Parabasalids

  2018cites this paper
• The hidden nature of protein translational control by diphthamide: the secrets under the leather.

  2018cites this paper
• Interplay between reversible phosphorylation and irreversible ADP-ribosylation of eukaryotic translation elongation factor 2

  2018cites this paper
• Noncanonical Radical SAM Enzyme Chemistry Learned from Diphthamide Biosynthesis.

  2018cites this paper
• CRISPR-based screen for Hedgehog signaling provides insights into function

  2018cites this paper
• Diphthamide affects selenoprotein expression: Diphthamide deficiency reduces selenocysteine incorporation, decreases selenite sensitivity and pre-disposes to oxidative stress

  2018cites this paper
• BL22: A Milestone in Targeting CD22

  2017cites this paper
• Evolutionary Conservation and Emerging Functional Diversity of the Cytosolic Hsp70:J Protein Chaperone Network of Arabidopsis thaliana

  2017cites this paper
• A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies

  2017cites this paper
• Influence of DPH1 and DPH5 Protein Variants on the Synthesis of Diphthamide, the Target of ADP-Ribosylating Toxins

  2017cites this paper
• Elp3 and Dph3 of Schizosaccharomyces pombe mediate cellular stress responses through tRNALysUUU modifications

  2017cites this paper
• A comprehensive portrait of cilia and ciliopathies from a CRISPR-based screen for Hedgehog signaling

  2017cites this paper
• High-resolution structure of the human translation termination complex

  2016cites this paper
• Identification and characterization of novel evolutionarily conserved protein methyltransferases

  2015cites this paper
• Factors that Determine Sensitivity and Resistances of Tumor Cells Towards Antibody-Targeted Protein Toxins

  2015cites this paper
• Immunoconjugates in the management of hairy cell leukemia.

  2015cites this paper
• Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor

  2015cites this paper
• The diphthamide modification pathway from Saccharomyces cerevisiae – revisited

  2014cites this paper
• Identification and Characterization of a Novel Evolutionarily Conserved Lysine-specific Methyltransferase Targeting Eukaryotic Translation Elongation Factor 2 (eEF2)*

  2014cites this paper
• Mechanisms of translational regulation in the pancreatic β cell stress response

  2014cites this paper
• Characterization of the mono-ADP-ribosylation by ARTD10 : substrates, consequences and reversibility

  2014cites this paper
• Role of OVCA1/DPH1 in craniofacial abnormalities of Miller-Dieker syndrome.

  2014cites this paper
• The biosynthesis and biological function of diphthamide

  2013influential citation
• Molecular mechanisms underlying the neuroprotective effect of IGF-1 in neuroblastoma cells and the pro-metastatic effect of Dph3 in murine melanoma cells

  2013cites this paper
• The Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6, a Gene Identified through Mining the DPH1-DPH5 Interaction Network

  2013cites this paper
• The Discovery And Functional Studies Of Two Diphthamide Biosynthetic Genes

  2013influential citation
• A network of cytosolic factors targets SRP-independent proteins to the endoplasmic reticulum.

  2013cites this paper
• New genes involved in the synthesis of diphthamide, a modification of eukaryotic translation elongation factor 2 with roles in diphtheria disease and ovarian cancer formation

  2013influential citation
• Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy

  2012cites this paper
• Fidélité de la traduction chez les eucaryotes. De la molécule au génome

  2012cites this paper
• The elongation, termination, and recycling phases of translation in eukaryotes.

  2012cites this paper
• Identification of Cellular Components Interacting with the Shiga-like Toxin 1 A1 Chain (SLT-1 A1) By

  2012cites this paper
• Proteomics analysis of in vitro protein methylation during Src‐induced transformation

  2012cites this paper
• Diphtheria Disease and Genes Involved in Formation of Diphthamide, Key Effector of the Diphtheria Toxin

  2012cites this paper
• Silencing of Diphthamide Synthesis 3 (Dph3) Reduces Metastasis of Murine Melanoma

  2012cites this paper
• Structure and Mechanistic Insights into Novel Iron-mediated Moonlighting Functions of Human J-protein Cochaperone, Dph4

  2012cites this paper
• Chemogenomic approach identified yeast YLR143W as diphthamide synthetase

  2012cites this paper
• Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development

  2012cites this paper
• Synthetic lethal interactions in yeast reveal functional roles of J protein co-chaperones.

  2012cites this paper
• Comparative genomic analysis of the DUF71/COG2102 family predicts roles in diphthamide biosynthesis and B12 salvage

  2012cites this paper
• Antibody Fusion Proteins: Anti-CD22 Recombinant Immunotoxin Moxetumomab Pasudotox

  2011cites this paper
• A guide to taming a toxin – recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer

  2011cites this paper
• Towards a Systems Approach in the Genetic Analysis of Archaea: Accelerating Mutant Construction and Phenotypic Analysis in Haloferax volcanii

  2010cites this paper
• A Dominant-Negative Approach That Prevents Diphthamide Formation Confers Resistance to Pseudomonas Exotoxin A and Diphtheria Toxin

  2010cites this paper
• Recombinant immunotoxins for the treatment of chemoresistant hematologic malignancies.

  2009cites this paper
• Analysis of Pax6 Contiguous Gene Deletions in the Mouse, Mus musculus, Identifies Regions Distinct from Pax6 Responsible for Extreme Small-Eye and Belly-Spotting Phenotypes

  2009cites this paper