The vital link between the ubiquitin-proteasome pathway and DNA repair: impact on cancer therapy.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Cancer Letters

• Publication date

  2009-09-28

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.canlet.2008.12.030PMID 19201084
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The endless tale of non-homologous end-joining

  2008cited by this paper
• Eukaryotic nucleotide excision repair: from understanding mechanisms to influencing biology

  2008cited by this paper
• Homologous recombination in DNA repair and DNA damage tolerance

  2008cited by this paper
• RNF8-dependent and RNF8-independent Regulation of 53BP1 in Response to DNA Damage*

  2008cited by this paper
• Eukaryotic DNA damage tolerance and translesion synthesis through covalent modifications of PCNA

  2008cited by this paper
• Transcription-coupled nucleotide excision repair in mammalian cells: molecular mechanisms and biological effects

  2008cited by this paper
• Proteasome inhibitors remarkably prevent translesion replication in cancer cells but not normal cells

  2008cited by this paper
• Paradigms for the three rs: DNA replication, recombination, and repair.

  2007cited by this paper
• The proteasome is involved in determining differential utilization of double-strand break repair pathways

  2007cited by this paper
• Nucleotide excision repair and the ubiquitin proteasome pathway--do all roads lead to Rome?

  2007cited by this paper
• Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells.

  2007cited by this paper
• Randomized phase III study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: combination therapy improves time to progression.

  2007cited by this paper
• Proteasome-Independent Functions of Ubiquitin in Endocytosis and Signaling

  2007cited by this paper
• Polymerase eta is a short-lived, proteasomally degraded protein that is temporarily stabilized following UV irradiation in Saccharomyces cerevisiae.

  2007cited by this paper
• RAD18 and Poly(ADP-Ribose) Polymerase Independently Suppress the Access of Nonhomologous End Joining to Double-Strand Breaks and Facilitate Homologous Recombination-Mediated Repair

  2007cited by this paper
• A proteasome for all occasions

  2007cited by this paper
• RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.

  2007cited by this paper
• DNA damage checkpoints: from initiation to recovery or adaptation.

  2007cited by this paper
• Regulation of Pax3 by proteasomal degradation of monoubiquitinated protein in skeletal muscle progenitors.

  2007cited by this paper
• RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.

  2007cited by this paper
• A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination.

  2007cited by this paper
• Many faces of NF-kappaB signaling induced by genotoxic stress.

  2007cited by this paper
• MDM2 and MDM4: p53 regulators as targets in anticancer therapy.

  2007cited by this paper
• Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase

  2007cited by this paper
• Leading Edge Minireview Proteasomes : Machines for All Reasons

  2007cited by this paper
• The DNA damage response: ten years after.

  2007cited by this paper
• Proteasome function is required for DNA damage response and fanconi anemia pathway activation.

  2007cited by this paper
• Many faces of NF-κB signaling induced by genotoxic stress

  2007cited by this paper
• Ubiquitin- and ATP-independent proteolytic turnover of p21 by the REGgamma-proteasome pathway.

  2007cited by this paper
• Proteasome inhibitors: antitumor effects and beyond

  2007cited by this paper
• Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins

  2007cited by this paper
• A ubiquitin ligase complex assembles linear polyubiquitin chains

  2006cited by this paper
• DSS1 is required for the stability of BRCA2

  2006cited by this paper
• UV-induced ubiquitylation of XPC complex, the UV-DDB-ubiquitin ligase complex, and DNA repair

  2006cited by this paper
• Lysine‐63‐linked ubiquitination is required for endolysosomal degradation of class I molecules

  2006cited by this paper
• Differential usage of non-homologous end-joining and homologous recombination in double strand break repair.

  2006cited by this paper
• A dynamic ubiquitin equilibrium couples proteasomal activity to chromatin remodeling

  2006cited by this paper
• Proteasome inhibitors in lung cancer.

  2006cited by this paper
• Molecular mechanisms of mammalian global genome nucleotide excision repair.

  2006cited by this paper
• MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo.

  2006cited by this paper
• NF-kappaB and IKK as therapeutic targets in cancer.

  2006cited by this paper
• Cullin 4A-mediated Proteolysis of DDB2 Protein at DNA Damage Sites Regulates in Vivo Lesion Recognition by XPC*

  2006cited by this paper
• NF-κB and IKK as therapeutic targets in cancer

  2006cited by this paper
• The proteasome and proteasome inhibitors in cancer therapy.

  2006cited by this paper
• MLN120B, a Novel IκB Kinase β Inhibitor, Blocks Multiple Myeloma Cell Growth In vitro and In vivo

  2006cited by this paper
• Controlling the subcellular localization of DNA polymerases ι and η via interactions with ubiquitin

  2006cited by this paper
• Proteasome Inhibition in the Treatment of Cancer

  2005cited by this paper
• Cellular ubiquitination and proteasomal functions positively modulate mammalian nucleotide excision repair

  2005cited by this paper
• Proteasome inhibition in multiple myeloma: therapeutic implication.

  2005cited by this paper
• The novel functions of ubiquitination in signaling.

  2004cited by this paper
• Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints.

  2004cited by this paper
• Sem1, the yeast ortholog of a human BRCA2-binding protein, is a component of the proteasome regulatory particle that enhances proteasome stability

  2004cited by this paper
• The proteasome: a suitable antineoplastic target

  2004cited by this paper
• Rad23 and Rpn10 Serve as Alternative Ubiquitin Receptors for the Proteasome*

  2004cited by this paper
• The interplay of Fanconi anemia proteins in the DNA damage response.

  2004cited by this paper
• Proteasome involvement in the repair of DNA double-strand breaks.

  2004cited by this paper
• Sem1p Is a Novel Subunit of the 26 S Proteasome from Saccharomyces cerevisiae*

  2004cited by this paper
• Proteasome inhibitors disrupt the unfolded protein response in myeloma cells

  2003cited by this paper
• The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.

  2003cited by this paper
• The link between 20S proteasome activity and post‐replication DNA repair in Saccharomyces cerevisiae

  2003cited by this paper
• Potential for proteasome inhibition in the treatment of cancer.

  2003cited by this paper
• The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications.

  2003cited by this paper
• Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341.

  2003cited by this paper
• NF-kappa B as a therapeutic target in multiple myeloma.

  2002cited by this paper
• Regulation of Repair by the 26S Proteasome

  2002cited by this paper
• BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.

  2002cited by this paper
• Maintenance of Genome Stability in Saccharomyces cerevisiae

  2002cited by this paper
• A role for Rad23 proteins in 26S proteasome-dependent protein degradation?

  2002cited by this paper
• NF-κB as a Therapeutic Target in Multiple Myeloma*

  2002cited by this paper
• Proteasome subunit Rpn1 binds ubiquitin-like protein domains

  2002cited by this paper
• Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-kappaB.

  2001cited by this paper
• The 19S complex of the proteasome regulates nucleotide excision repair in yeast.

  2001cited by this paper
• Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition.

  2001cited by this paper
• Apoptosis and radiosensitization of hodgkin cells by proteasome inhibition.

  2000cited by this paper
• Role of p53 in cell cycle regulation and apoptosis following exposure to proteasome inhibitors.

  2000cited by this paper
• Prevention of cisplatin-DNA adduct repair and potentiation of cisplatin-induced apoptosis in ovarian carcinoma cells by proteasome inhibitors.

  2000cited by this paper
• The 19S regulatory complex of the proteasome functions independently of proteolysis in nucleotide excision repair.

  1999cited by this paper
• Interaction between the Product of the Breast Cancer Susceptibility Gene BRCA2 and DSS1, a Protein Functionally Conserved from Yeast to Mammals

  1999cited by this paper
• Proteasome inhibitors: a novel class of potent and effective antitumor agents.

  1999cited by this paper
• Interaction of hHR23 with S5a

  1999cited by this paper
• Tumor growth inhibition induced in a murine model of human Burkitt's lymphoma by a proteasome inhibitor.

  1998cited by this paper
• Rad23 links DNA repair to the ubiquitin/proteasome pathway

  1998cited by this paper
• Lactacystin, a specific inhibitor of the proteasome, induces apoptosis in human monoblast U937 cells.

  1995cited by this paper
• Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23.

  1994cited by this paper
• The Saccharomyces cerevisiae DNA repair gene RAD23 encodes a nuclear protein containing a ubiquitin-like domain required for biological function

  1993cited by this paper

• β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

  2025cites this paper
• Disrupting DDB2-DNA Interaction by Lapatinib Enhances Chemotherapy Sensitivity

  2025cites this paper
• Multi-omics analysis identifies UBA family as potential pan-cancer biomarkers for tumor prognosis and immune microenvironment infiltration

  2025cites this paper
• The HIV Protease Inhibitor Ritonavir Reverts the Mesenchymal Phenotype Induced by Inflammatory Cytokines in Normal and Tumor Oral Keratinocytes to an Epithelial One, Increasing the Radiosensitivity of Tumor Oral Keratinocytes

  2025cites this paper
• Modulation of the ubiquitin‐proteasome system by phytochemicals: Therapeutic implications in malignancies with an emphasis on brain tumors

  2023cites this paper
• Proteomic profile of BxPC-3 cells after treatment with BRC4.

  2023cites this paper
• Proteasome activity modulates amyloid toxicity.

  2022cites this paper
• New Agents for the Treatment of T-Cell Acute Lymphoblastic Leukemia

  2022cites this paper
• DNA damage-induced sumoylation of Sp1 induces its interaction with RNF4 and degradation in S phase to remove 53BP1 from DSBs and permit HR.

  2022cites this paper
• Mitochondrial Determinants of Anti-Cancer Drug-Induced Cardiotoxicity

  2022cites this paper
• Urinary proteomic profiles of prostate cancer with different risk of progression and correlation with histopathological features.

  2021cites this paper
• The Landscape of Signaling Pathways and Proteasome Inhibitors Combinations in Multiple Myeloma

  2021cites this paper
• Knockdown of PSMC2 contributes to suppression of cholangiocarcinoma development by regulating CDK1

  2021cites this paper
• PSMC2/ITGA6 axis plays critical role in the development and progression of hepatocellular carcinoma

  2021cites this paper
• Immunoproteasome Function in Normal and Malignant Hematopoiesis

  2021cites this paper
• The chemical environmental pollutants BPA and BPS induce alterations of the proteomic profile of different phenotypes of human breast cancer cells: A proposed interactome.

  2020cites this paper
• Proteasome inhibition prevents cell death induced by the chemotherapeutic agent cisplatin downstream of DNA damage.

  2019cites this paper
• Proteasomes: unfoldase-assisted protein degradation machines

  2019cites this paper
• Aberrations in DNA repair pathways in cancer and therapeutic significances.

  2019cites this paper
• Modulating the DNA Damage Response to Improve Treatment Response in Cervical Cancer.

  2017cites this paper
• miR-100 antagonism triggers apoptosis by inhibiting ubiquitination-mediated p53 degradation

  2017cites this paper
• Apoptosis Induction and Gene Expression Profile Alterations of Cutaneous T-Cell Lymphoma Cells following Their Exposure to Bortezomib and Methotrexate

  2017cites this paper
• PID1 increases chemotherapy-induced apoptosis in medulloblastoma and glioblastoma cells in a manner that involves NFκB

  2017cites this paper
• Dynamic Behavior of the RNA Polymerase II and the Ubiquitin Proteasome System During the Neuronal DNA Damage Response to Ionizing Radiation

  2016cites this paper
• Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage*

  2015cites this paper
• Identification of reproducible drug-resistance-related dysregulated genes in small-scale cancer cell line experiments

  2015cites this paper
• Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage*□S

  2015cites this paper
• The Hsp90 inhibitor SNX-7081 is synergistic with fludarabine nucleoside via DNA damage and repair mechanisms in human, p53-negative chronic lymphocytic leukemia

  2015cites this paper
• PSMD9 expression predicts radiotherapy response in breast cancer

  2014cites this paper
• Nucleotide excision repair and the 26S proteasome function together to promote trinucleotide repeat expansions.

  2014cites this paper
• Cancer Biology and Signal Transduction Nedd 8-Activating Enzyme Inhibitor MLN 4924 Provides Synergy with Mitomycin C through Interactions with ATR , BRCA 1 / BRCA 2 , and Chromatin Dynamics Pathways

  2014cites this paper
• Nedd8-Activating Enzyme Inhibitor MLN4924 Provides Synergy with Mitomycin C through Interactions with ATR, BRCA1/BRCA2, and Chromatin Dynamics Pathways

  2014cites this paper
• Discovery of Polyphenol‐Based Drugs for Cancer Prevention and Treatment: The Tumor Proteasome as a Novel Target

  2014cites this paper
• Interplays between Sumoylation, SUMO-Targeted Ubiquitin Ligases, and the Ubiquitin-Adaptor Protein Ufd1 in Fission Yeast

  2014cites this paper
• The role of the CTD phosphatase Rrt1 and post-translational modifications in regulation of RNA polymerase II

  2014cites this paper
• Targeting homologous recombination-mediated DNA repair in cancer

  2014influential citation
• The 26S proteasome drives trinucleotide repeat expansions

  2013cites this paper
• Regulation of DNA damage responses by ubiquitin and SUMO.

  2013cites this paper
• Identification of novel factors that promote trinucleotide repeat instability

  2013cites this paper
• The 26S proteasome complex: an attractive target for cancer therapy.

  2012cites this paper
• Targeting tumor ubiquitin-proteasome pathway with polyphenols for chemosensitization.

  2012cites this paper
• Radiosensitization of Cancer Cells by Inactivation of Cullin-RING E3 Ubiquitin Ligases.

  2012cites this paper
• Effects of proteasome inhibition on cisplatin induced DNA damage responses in human cells

  2012influential citation
• Bioinformatic identification of genes suppressing genome instability

  2012cites this paper
• RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair.

  2012influential citation
• The 19S proteasome subunit Rpn7 stabilizes DNA damage foci upon genotoxic insult

  2012cites this paper
• Differential proteomics in the search for biomarkers of radiotherapy resistance

  2011cites this paper
• The Ubiquitin-Proteasome System and DNA Repair

  2011cites this paper
• A pilot study to investigate the role of the 26S proteasome in radiotherapy resistance and loco-regional recurrence following breast conserving therapy for early breast cancer.

  2011cites this paper
• Proteasome inhibitors in cancer therapy

  2011cites this paper
• Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast

  2011cites this paper
• Roles of the ubiquitin -proteasome system and mono-ubiquitination in regulating MHC class II transcription

  2010cites this paper
• Proteomic analysis of nuclei isolated from cancer cell lines treated with indenoisoquinoline NSC 724998, a novel topoisomerase I inhibitor.

  2010cites this paper
• A novel defect in mitochondrial p53 accumulation following DNA damage confers apoptosis resistance in Ataxia Telangiectasia and Nijmegen Breakage Syndrome T-cells.

  2010cites this paper
• Enhancement of cisplatin sensitivity by NSC109268 in budding yeast and human cancer cells is associated with inhibition of S-phase progression

  2010cites this paper
• Proteomic identification of putative biomarkers of radiotherapy resistance: a possible role for the 26S proteasome?

  2009cites this paper
• Proteasome inhibitors in cancer therapy.

  2009cites this paper
• A Quantitative Proteomics Analysis of Subcellular Proteome Localization and Changes Induced by DNA Damage

  2009cites this paper