CX3CL1 at the crossroad of EGF signals

M. Tardaguila,S. Mañes

Published 2013 in Oncoimmunology

ABSTRACT

Inflammatory mediators can play a dual role in oncogenesis and tumor progression. CX3CL1, a chemokine previously implicated in natural killer cell- and CD8+ T cell-mediated antitumor immune responses, has now been identified as a promoter of ERBB2-expressing breast carcinomas as it cross-activates members of the epidermal growth factor receptor family.

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