The effects of birth condition on infants' cortisol response to stress.

UNLABELLED OBJECTIVE, DESIGN, AND SUBJECTS: To examine the effects of nonoptimal birth condition on cortisol response to routine inoculation in a longitudinal sample of full-term healthy infants at 2, 4, and 6 months of age. MEASUREMENT AND MAIN RESULTS Optimal versus non-optimal birth condition was defined by a large versus small head circumference and a high versus low 1-minute Apgar score. An optimal birth condition was associated with a high cortisol response at 2 months, but a low cortisol response by 6 months of age. CONCLUSIONS The findings indicate a reversal in the meaning of high adrenocortical reactivity between 2 and 6 months of age: high cortisol response may index optimal functioning at 2 months, but nonoptimal functioning by 6 months of age. Together with other results, this reversal provides evidence for a developmental shift in adrenocortical functioning during this period. The findings also show that the effects of a nonoptimal birth condition in otherwise healthy full-term infants persist for at least the first 6 months of life.

• Publication year

  1995

• Venue

  Pediatrics

• Publication date

  1995-04-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1542/peds.95.4.546PMID 7700756
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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