Roles of disulfide bonds in recombinant human interleukin 6 conformation.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Biochemistry

• Publication date

  1994-05-03

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/BI00183A018PMID 8172889
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The structure of granulocyte-colony-stimulating factor and its relationship to other growth factors.

  1993cited by this paper
• Site-directed and deletion mutational analysis of the receptor binding domain of the interleukin-6 receptor targeted fusion toxin DAB389-IL-6.

  1993cited by this paper
• Analysis of human/mouse interleukin‐6 hybrid proteins: both amino and carboxy termini of human interleukin‐6 are required for in vitro receptor binding

  1992cited by this paper
• High affinity ligand binding is not essential for granulocyte-macrophage colony-stimulating factor receptor activation.

  1992cited by this paper
• Folding and oxidation of recombinant human granulocyte colony stimulating factor produced in Escherichia coli. Characterization of the disulfide-reduced intermediates and cysteine----serine analogs.

  1992cited by this paper
• Overexpression and structure--function analysis of a bioengineered IL-2/IL-6 chimeric lymphokine.

  1992cited by this paper
• Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.

  1992cited by this paper
• Effects of site-specific mutations on biologic activities of recombinant human IL-6.

  1991cited by this paper
• Identification of a functional domain of human granulocyte colony-stimulating factor using neutralizing monoclonal antibodies.

  1991cited by this paper
• Biological and clinical aspects of interleukin 6.

  1990cited by this paper
• Interleukin-6: an overview.

  1990cited by this paper
• Intermediates in the folding reactions of small proteins.

  1990cited by this paper
• Structure‐function analysis of human interleukin‐6

  1990cited by this paper
• Haemopoietic receptors and helical cytokines.

  1990cited by this paper
• Structure-function analysis of human IL-6. Epitope mapping of neutralizing monoclonal antibodies with amino- and carboxyl-terminal deletion mutants.

  1990cited by this paper
• Establishment of strongly neutralizing monoclonal antibody to human interleukin-6 and its epitope analysis.

  1989cited by this paper
• Mutagenesis of human granulocyte colony stimulating factor.

  1989cited by this paper
• Analysis of human IL-6 mutants expressed in Escherichia coli. Biologic activities are not affected by deletion of amino acids 1-28.

  1989cited by this paper
• Disulfide and secondary structures of recombinant human granulocyte colony stimulating factor.

  1989cited by this paper
• Molecular cloning of the chicken myelomonocytic growth factor (cMGF) reveals relationship to interleukin 6 and granulocyte colony stimulating factor.

  1989cited by this paper
• Disulfide structures of human interleukin-6 are similar to those of human granulocyte colony stimulating factor.

  1989cited by this paper
• Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130.

  1989cited by this paper
• Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human.

  1988cited by this paper
• High-level expression of a bioengineered, cysteine-free hepatocyte-stimulating factor (interleukin 6)-like protein.

  1988cited by this paper
• Functional discrimination between interleukin 6 and interleukin 1

  1988cited by this paper
• Characterization of a recombinant murine interleukin-6: assignment of disulfide bonds.

  1988cited by this paper
• Three-dimensional structure of a genetically engineered variant of porcine growth hormone.

  1987cited by this paper
• Receptors for B cell stimulatory factor 2. Quantitation, specificity, distribution, and regulation of their expression

  1987cited by this paper
• Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

  1986cited by this paper
• Isolation and characterization of the cDNA for murine granulocyte colony-stimulating factor.

  1986cited by this paper
• Estimation of globular protein secondary structure from circular dichroism.

  1981cited by this paper
• The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent.

  1973cited by this paper
• Form-determining function of the genes required for the assembly of the head of bacteriophage T4.

  1970cited by this paper

• Label-free SERS for rapid identification of interleukin 6 based on intrinsic SERS fingerprint of antibody‑gold nanoparticles conjugate.

  2023cites this paper
• The glutathione peroxidase 8 (GPX8)/IL-6/STAT3 axis is essential in maintaining an aggressive breast cancer phenotype

  2020cites this paper
• Glutathione Peroxidase 8 (GPX8)-IL6 axis is essential in maintaining breast cancer mesenchymal stem-like state and aggressive phenotype

  2019cites this paper
• Improved detection of biomarkers in cervico-vaginal mucus (CVM) from postpartum cattle

  2018cites this paper
• Enhancing recombinant interleukin‐6 production yield by fermentation optimization, two‐step denaturing, and one‐step purification

  2018cites this paper
• Interleukin-6 and Exercise-Induced Cardioprotection

  2014cites this paper
• Formation of disulfide bonds in insect prophenoloxidase enhances immunity through improving enzyme activity and stability.

  2014cites this paper
• Semisynthesis of biologically active glycoforms of the human cytokine interleukin 6.

  2014cites this paper
• The bioactivity of teleost IL-6: IL-6 protein in orange-spotted grouper (Epinephelus coioides) induces Th2 cell differentiation pathway and antibody production.

  2012cites this paper
• Large-scale production, purification and bioactivity assay of recombinant human interleukin-6 in the methylotrophic yeast Pichia pastoris.

  2011cites this paper
• Rapid mRNA-display selection of an IL-6 inhibitor using continuous-flow magnetic separation.

  2011cites this paper
• Large-scale production, puri¢cation and bioactivity assay of recombinant human interleukin-6 in the methylotrophic yeast Pichiapastoris

  2011cites this paper
• Synthesis, solution conformation and interleukin-6-related activities of interleukin-6 peptides.

  2009cites this paper
• Negative modulation of signal transduction via interleukin splice variation

  2008cites this paper
• The role of disulfide bonds in the structure and function of murine epidermal growth factor (mEGF)

  2005cites this paper
• Neutralization effects of interleukin-6 (IL-6) antibodies on sulfur mustard (HD)-induced IL-6 secretion on human epidermal keratinocytes.

  2004cites this paper
• Interleukin-6 N-Terminal Peptides Modulate the Expression of junB Protooncogene and the Production of Fibrinogen in HepG2 Cells

  2003cites this paper
• Effect of in situ expression of human interleukin-6 on antibody responses against Salmonella typhimurium antigens.

  2003cites this paper
• Cloning and hemolysin-mediated secretory expression of a codon-optimized synthetic human interleukin-6 gene in Escherichia coli.

  2002cites this paper
• Sub-zero temperature inactivation of carboxypeptidase Y under high hydrostatic pressure.

  2002cites this paper
• Application of combined reagent solution to the oxidative refolding of recombinant human interleukin 6.

  2001cites this paper
• Hierarchical protein folding: asymmetric unfolding of an insulin analogue lacking the A7-B7 interchain disulfide bridge.

  2001cites this paper
• The Role of Interleukin-6 (IL-6) in Human Sulfur Mustard (HD) Toxicology

  2001influential citation
• Human Herpesvirus 8 Interleukin-6 (vIL-6) Signals through gp130 but Has Structural and Receptor-Binding Properties Distinct from Those of Human IL-6

  1999cites this paper
• Nitric oxide and thiol redox regulation of Janus kinase activity.

  1998cites this paper
• Disruption of the disulfide bonds of recombinant murine interleukin-6 induces formation of a partially unfolded state.

  1997cites this paper
• Interleukin‐6: Structure‐function relationships

  1997influential citation
• Acid-induced molten globule state of a fully active mutant of human interleukin-6.

  1996cites this paper
• The Liptin Haemopoietic Cytokine Fold is Stabilized by an Intrachain Disulfide Bond

  1996cites this paper
• The leptin haemopoietic cytokine fold is stabilized by an intrachain disulfide bond.

  1996cites this paper
• Complete 1H, 15N and 13C assignments, secondary structure, and topology of recombinant human interleukin-6

  1996cites this paper
• Identification of Single Amino Acid Residues of Human IL-6 Involved in Receptor Binding and Signal Initiation

  1996cites this paper
• Structure, stability and biological properties of a N-terminally truncated form of recombinant human interleukin-6 containing a single disulfide bond.

  1995cites this paper