Enhanced prefrontal serotonin 2A receptor signaling in the subchronic phencyclidine mouse model of schizophrenia

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Journal of Neuroscience Research

• Publication date

  2013-05-01

• Fields of study

  Medicine, Chemistry, Psychology

• Identifiers
  DOI 10.1002/jnr.23198PMID 23404493
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Repeated phencyclidine administration alters glutamate release and decreases GABA markers in the prefrontal cortex of rats.

  2012cited by this paper
• Glutamatergic animal models of schizophrenia.

  2012cited by this paper
• Maternal Influenza Viral Infection Causes Schizophrenia-Like Alterations of 5-HT2A and mGlu2 Receptors in the Adult Offspring

  2011cited by this paper
• Serotonin 2A receptor antagonists for treatment of schizophrenia

  2011cited by this paper
• Enhanced Function of Prefrontal Serotonin 5-HT2 Receptors in a Rat Model of Psychiatric Vulnerability

  2010influential reference
• Opposite effect of phencyclidine on activity-regulated cytoskeleton-associated protein (Arc) in juvenile and adult limbic rat brain regions.

  2010cited by this paper
• α7 nicotinic receptor agonism mitigates phencyclidine-induced changes in synaptophysin and Arc gene expression in the mouse prefrontal cortex.

  2010cited by this paper
• Decreased frontal serotonin2A receptor binding in antipsychotic-naive patients with first-episode schizophrenia.

  2010cited by this paper
• alpha(7) Nicotinic acetylcholine receptor activation prevents behavioral and molecular changes induced by repeated phencyclidine treatment.

  2009cited by this paper
• Involvement of the endocannabinoid system in phencyclidine-induced cognitive deficits modelling schizophrenia.

  2009cited by this paper
• PSD-95 Is Essential for Hallucinogen and Atypical Antipsychotic Drug Actions at Serotonin Receptors

  2009cited by this paper
• Evaluation of NMDA receptor models of schizophrenia: divergences in the behavioral effects of sub-chronic PCP and MK-801.

  2009cited by this paper
• Psychedelics and schizophrenia.

  2009cited by this paper
• The Immediate Early Gene Arc/Arg3.1: Regulation, Mechanisms, and Function

  2008cited by this paper
• Agonist-directed signaling of the serotonin 2A receptor depends on β-arrestin-2 interactions in vivo

  2008cited by this paper
• Models of schizophrenia in humans and animals based on inhibition of NMDA receptors.

  2008cited by this paper
• Modelling prefrontal cortex deficits in schizophrenia: implications for treatment

  2008cited by this paper
• Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone: role of serotonin 5-HT1A receptors.

  2008cited by this paper
• Evidence that genetic variation in 5-HT transporter expression is linked to changes in 5-HT2A receptor function.

  2008influential reference
• Identification of a serotonin/glutamate receptor complex implicated in psychosis

  2008cited by this paper
• NMDA Receptor Hypofunction Produces Opposite Effects on Prefrontal Cortex Interneurons and Pyramidal Neurons

  2007cited by this paper
• Antipsychotic drugs reverse the disruption in prefrontal cortex function produced by NMDA receptor blockade with phencyclidine

  2007cited by this paper
• Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior.

  2007influential reference
• Glutamate and Schizophrenia: Beyond the Dopamine Hypothesis

  2006cited by this paper
• Chandelier Cells Control Excessive Cortical Excitation: Characteristics of Whisker-Evoked Synaptic Responses of Layer 2/3 Nonpyramidal and Pyramidal Neurons

  2004cited by this paper
• Glutamate receptor activation is involved in 5-HT2 agonist-induced Arc gene expression in the rat cortex.

  2004cited by this paper
• Transcriptome Fingerprints Distinguish Hallucinogenic and Nonhallucinogenic 5-Hydroxytryptamine 2A Receptor Agonist Effects in Mouse Somatosensory Cortex

  2003cited by this paper
• Glutamatergic Animal Models of Schizophrenia

  2003cited by this paper
• The cortical serotonin2A receptor and the pathology of schizophrenia: a likely accomplice

  2003cited by this paper
• The Dynamin-dependent, Arrestin-independent Internalization of 5-Hydroxytryptamine 2A (5-HT2A) Serotonin Receptors Reveals Differential Sorting of Arrestins and 5-HT2A Receptors during Endocytosis* 210

  2001cited by this paper
• MS-377, a novel selective sigma(1) receptor ligand, reverses phencyclidine-induced release of dopamine and serotonin in rat brain.

  2001cited by this paper
• Cannabinoids of diverse structure inhibit two DOI-induced 5-HT(2A) receptor-mediated behaviors in mice.

  2001cited by this paper
• Modulation of 5-HT(2A) receptor-mediated head-twitch behaviour in the rat by 5-HT(2C) receptor agonists.

  2001influential reference
• Serotonergic regulation of mRNA expression of Arc, an immediate early gene selectively localized at neuronal dendrites.

  2000cited by this paper
• GABAergic local circuit neurons and prefrontal cortical dysfunction in schizophrenia.

  2000cited by this paper
• Inhibition of Activity-Dependent Arc Protein Expression in the Rat Hippocampus Impairs the Maintenance of Long-Term Potentiation and the Consolidation of Long-Term Memory

  2000cited by this paper
• Clinical and theoretical implications of 5-HT2 and D2 receptor occupancy of clozapine, risperidone, and olanzapine in schizophrenia.

  1999cited by this paper
• The Neuropsychopharmacology of Phencyclidine: From NMDA Receptor Hypofunction to the Dopamine Hypothesis of Schizophrenia

  1999cited by this paper
• Psilocybin induces schizophrenia‐like psychosis in humans via a serotonin‐2 agonist action

  1998cited by this paper
• Effects of 5-hydroxytryptamine2 receptor antagonism on the behavioral activation and immediate early gene expression induced by dizocilpine.

  1998cited by this paper
• Ketamine-Induced Exacerbation of Psychotic Symptoms and Cognitive Impairment in Neuroleptic-Free Schizophrenics

  1997cited by this paper
• Direct injection of 5-HT2A receptor agonists into the medial prefrontal cortex produces a head-twitch response in rats.

  1997cited by this paper
• NMDA Receptor Function and Human Cognition: The Effects of Ketamine in Healthy Volunteers

  1996cited by this paper
• Effects of risperidone on phencyclidine-induced behaviors: comparison with haloperidol and ritanserin.

  1994cited by this paper
• Phencyclidine-induced head-twitch responses as 5-HT2 receptor-mediated behavior in rats.

  1987cited by this paper

• Relationship between increased binding potential of possible 5-HT2A receptors in the ventral hippocampus by subchronic phencyclidine and disturbed social interaction in rats: a PET study using 18F-altanserin.

  2025cites this paper
• Psychotomimetic compensation versus sensitization

  2024cites this paper
• DSP-6745, a novel 5-hydroxytryptamine modulator with rapid antidepressant, anxiolytic, antipsychotic and procognitive effects

  2024cites this paper
• 1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI): From an Obscure to Pivotal Member of the DOX Family of Serotonergic Psychedelic Agents – A Review

  2024cites this paper
• The history of Danish neuroscience

  2023cites this paper
• 5-HT2A receptor dysregulation in a schizophrenia relevant mouse model of NMDA receptor hypofunction

  2022cites this paper
• Sustained NMDA receptor hypofunction impairs brain-derived neurotropic factor signalling in the PFC, but not in the hippocampus, and disturbs PFC-dependent cognition in mice

  2021cites this paper
• Serotonin 2A receptors and cannabinoids.

  2021cites this paper
• N, N-dimethylglycine protects behavioral disturbances and synaptic deficits induced by repeated ketamine exposure in mice.

  2021cites this paper
• Sustained NMDA receptor hypofunction impairs brain-derived neurotropic factor (BDNF) signalling in the prefrontal cortex (PFC), but not in the hippocampus, and disturbs PFC-dependent cognition in mice Running head: BDNF function is lost in PFC of PCP-treated mice

  2021influential citation
• Increased behavioral and neuronal responses to a hallucinogenic drug after adolescent toluene exposure in mice: Effects of antipsychotic treatment.

  2020cites this paper
• Serotonin 5-HT2A receptor expression and functionality in postmortem frontal cortex of subjects with schizophrenia: Selective biased agonism via Gαi1-proteins.

  2019cites this paper
• Metabotropic Glutamate Receptor 2 and Dopamine Receptor 2 Gene Expression Predict Sensorimotor Gating Response in the Genetically Heterogeneous NIH-HS Rat Strain

  2019cites this paper
• Chronic methamphetamine self‐administration dysregulates 5‐HT2A and mGlu2 receptor expression in the rat prefrontal and perirhinal cortex: Comparison to chronic phencyclidine and MK‐801

  2018cites this paper
• Early emergence of altered 5‐HT2A receptor‐evoked behavior, neural activation and gene expression following maternal separation

  2018cites this paper
• Chronic cannabis promotes pro-hallucinogenic signaling of 5-HT2A receptors through Akt/mTOR pathway

  2018cites this paper
• The use of antioxidant compounds in the treatment of first psychotic episode: Highlights from preclinical studies

  2018cites this paper
• Hallucinogens and Serotonin 5-HT2A Receptor-Mediated Signaling Pathways.

  2018cites this paper
• Differences in 5-HT2A and mGlu2 Receptor Expression Levels and Repressive Epigenetic Modifications at the 5-HT2A Promoter Region in the Roman Low- (RLA-I) and High- (RHA-I) Avoidance Rat Strains

  2017cites this paper
• The prolyl oligopeptidase inhibitor IPR19 ameliorates cognitive deficits in mouse models of schizophrenia.

  2017cites this paper
• Prolonged reversal of the phencyclidine-induced impairment in novel object recognition by a serotonin (5-HT)1A-dependent mechanism.

  2016cites this paper
• Assessment of Potential Long Term Health Effects on Army Human Test Subjects of Relevant Biological and Chemical Agents, Drugs, Medications and Substances

  2016cites this paper
• Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model

  2016cites this paper
• The 5-HT2A serotonin receptor in executive function: Implications for neuropsychiatric and neurodegenerative diseases.

  2016cites this paper
• Progress in Neurobiology How serotonin receptors regulate morphogenic signalling in neurons

  2016cites this paper
• Visualization of 5‐HT Receptors Using Radioligand‐Binding Autoradiography

  2016cites this paper
• Overview about the localization of nanoparticles in tissue and cellular context by different imaging techniques

  2015cites this paper
• Preview : Published ahead of advance online publication

  2015cites this paper
• Differences in central serotoninergic transmission among patients with recent onset, sub-chronic, and chronic schizophrenia as assessed by the loudness dependence of auditory evoked potentials.

  2015cites this paper
• Combined serotonin (5-HT)1A agonism, 5-HT(2A) and dopamine D₂ receptor antagonism reproduces atypical antipsychotic drug effects on phencyclidine-impaired novel object recognition in rats.

  2015cites this paper
• Maternal lipopolysaccharide treatment differentially affects 5-HT(2A) and mGlu2/3 receptor function in the adult male and female rat offspring.

  2015cites this paper
• Enhanced calcium responses to serotonin receptor stimulation in T-lymphocytes from schizophrenic patients--a pilot study.

  2015cites this paper
• Long-lasting alterations in 5-HT2A receptor after a binge regimen of methamphetamine in mice.

  2014cites this paper
• The effects of olanzapine on genome-wide DNA methylation in the hippocampus and cerebellum

  2014cites this paper
• Olanzapine-induced methylation alters cadherin gene families and associated pathways implicated in psychosis

  2014cites this paper
• Animal Models of Psychosis: Current State and Future Directions

  2014cites this paper
• Regulating Prefrontal Cortex Activation: An Emerging Role for the 5-HT2A Serotonin Receptor in the Modulation of Emotion-Based Actions?

  2013cites this paper