Multiple enhancer regions located at significant distances upstream of the transcriptional start site mediate RANKL gene expression in response to 1,25-dihydroxyvitamin D3.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Steroid Biochemistry and Molecular Biology

• Publication date

  2007-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.JSBMB.2006.12.020PMID 17197168PMCID PMC1892901
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A high-resolution map of active promoters in the human genome

  2005cited by this paper
• NF-Y Is Essential for the Recruitment of RNA Polymerase II and Inducible Transcription of Several CCAAT Box-Containing Genes

  2005cited by this paper
• Direct isolation and identification of promoters in the human genome.

  2005cited by this paper
• High-throughput screening of chromatin immunoprecipitates using CpG-island microarrays.

  2004cited by this paper
• Genome-Wide Mapping of the Cohesin Complex in the Yeast Saccharomyces cerevisiae

  2004cited by this paper
• 1,25‐Dihydroxyvitamin D3 Stimulates Cyclic Vitamin D Receptor/Retinoid X Receptor DNA‐Binding, Co‐activator Recruitment, and Histone Acetylation in Intact Osteoblasts

  2004cited by this paper
• Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27.

  2004cited by this paper
• Regulation of RANKL promoter activity is associated with histone remodeling in murine bone stromal cells

  2004cited by this paper
• 2-Methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 Potently Stimulates Gene-specific DNA Binding of the Vitamin D Receptor in Osteoblasts*

  2003cited by this paper
• Cbfa1 does not regulate RANKL gene activity in stromal/osteoblastic cells.

  2002cited by this paper
• A potent analog of 1α,25-dihydroxyvitamin D3 selectively induces bone formation

  2002cited by this paper
• A potent analog of 1alpha,25-dihydroxyvitamin D3 selectively induces bone formation.

  2002cited by this paper
• Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand.

  1999cited by this paper
• Osteoclast differentiation factor acts as a multifunctional regulator in murine osteoclast differentiation and function.

  1999cited by this paper
• Promoter structure of mouse RANKL/TRANCE/OPGL/ODF gene.

  1999cited by this paper
• OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

  1999cited by this paper
• Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.

  1998cited by this paper

• In vivo vitamin D target genes interconnect key signaling pathways of innate immunity

  2024cites this paper
• Antioxidant Functions of Vitamin D and CYP11A1-Derived Vitamin D, Tachysterol, and Lumisterol Metabolites: Mechanisms, Clinical Implications, and Future Directions

  2024cites this paper
• Vitamin D and Aging: Central Role of Immunocompetence

  2024cites this paper
• Genomic Mechanisms Controlling Renal Vitamin D Metabolism.

  2023cites this paper
• Molecular insights into mineralotropic hormone inter-regulation

  2023cites this paper
• Association of 25-Hydroxy Vitamin D with IL-17 Inflammatory Cytokines, and Osteoporosis in patients with Rheumatoid Arthritis in Kurdish nation / Iraq

  2022cites this paper
• Vitamin D in the Context of Evolution

  2022cites this paper
• Vitamin D and evolution: pharmacologic implications.

  2020cites this paper
• Genome-wide effects of chromatin on vitamin D signaling.

  2020cites this paper
• Is cholecalciferol a potential disease modifying anti-rheumatic drug for the management of rheumatoid arthritis?

  2019cites this paper
• 1,25-Dihydroxyvitamin D3 enhances glucose-stimulated insulin secretion in mouse and human islets: a role for transcriptional regulation of voltage-gated calcium channels by the vitamin D receptor.

  2019cites this paper
• Vitamin D: A Micronutrient Regulating Genes.

  2019cites this paper
• Vitamin D Signaling in the Context of Innate Immunity: Focus on Human Monocytes

  2019cites this paper
• Vitamin D, Inflammation and Osteoporosis in Rheumatoid Arthritis

  2018cites this paper
• Steroid Hormone Vitamin D: Implications for Cardiovascular Disease.

  2018cites this paper
• Mesenchymal Differentiation, Epigenetic Dynamics, and Interactions With VDR

  2018cites this paper
• Multiple Functional Variants at 13q14 Risk Locus for Osteoporosis Regulate RANKL Expression Through Long‐Range Super‐Enhancer

  2018cites this paper
• New Insights on Low Vitamin D Plasma Concentration as a Potential Cardiovascular Risk Factor.

  2018cites this paper
• SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts

  2017cites this paper
• Multiple Sclerosis in Women: Vitamin D and Estrogen Synergy for Autoimmune T-Cell Regulation and Demyelinating Disease Prevention

  2017cites this paper
• UVB Exposure Prevents Atherosclerosis by Regulating Immunoinflammatory Responses

  2017cites this paper
• TNFα Increases RANKL Expression via PGE2-Induced Activation of NFATc1

  2017cites this paper
• Role of Vitamin D in Rheumatoid Arthritis.

  2017cites this paper
• Absence of the Vitamin D Receptor Inhibits Atherosclerotic Plaque Calcification in Female Hypercholesterolemic Mice

  2017cites this paper
• Epigenetic Plasticity Drives Adipogenic and Osteogenic Differentiation of Marrow-derived Mesenchymal Stem Cells*

  2016cites this paper
• Unique Distal Enhancers Linked to the Mouse Tnfsf11 Gene Direct Tissue-Specific and Inflammation-Induced Expression of RANKL.

  2016cites this paper
• Deletion of the Distal Tnfsf11 RL‐D2 Enhancer That Contributes to PTH‐Mediated RANKL Expression in Osteoblast Lineage Cells Results in a High Bone Mass Phenotype in Mice

  2016cites this paper
• Early response of the human SOST gene to stimulation by 1α,25-dihydroxyvitamin D3.

  2016cites this paper
• [Osteoporosis in Rheumatoid Arthritis: role of the vitamin D/parathyroid hormone system].

  2015cites this paper
• Vitamin D Actions on CD4+ T Cells in Autoimmune Disease

  2015cites this paper
• A DNA Segment Spanning the Mouse Tnfsf11 Transcription Unit and Its Upstream Regulatory Domain Rescues the Pleiotropic Biologic Phenotype of the RANKL Null Mouse

  2015cites this paper
• RNA interference-mediated knockdown of Smad1 inhibits receptor activator of nuclear factor κB ligand expression induced by BMP-2 in primary osteoblasts.

  2015cites this paper
• STAT-6 mediates TRAIL induced RANK ligand expression in stromal/preosteoblast cells.

  2015cites this paper
• Osteoporosis in rheumatoid arthritis: role of the vitamin D/parathyroid hormone system

  2015cites this paper
• Osteocyte-derived RANKL is a critical mediator of the increased bone resorption caused by dietary calcium deficiency.

  2014cites this paper
• Regulation of cortical and trabecular bone mass by communication between osteoblasts, osteocytes and osteoclasts.

  2014cites this paper
• Essential roles of Pdia3/PLAA receptor complex and CaMKII IN 1α,25(OH)₂D₃ and Wnt5a calcium-dependent signaling pathways in osteoblasts and chondrocytes

  2014cites this paper
• Detection of 1α,25-Dihydroxyvitamin D-Regulated miRNAs in Zebrafish by Whole Transcriptome Sequencing

  2014cites this paper
• Analyses of RANK and RANKL in the Post‐GWAS Context: Functional Evidence of Vitamin D Stimulation Through a RANKL Distal Region

  2013cites this paper
• Activated Human T Cells Express Alternative mRNA Transcripts Encoding a Secreted Form of RANKL

  2013cites this paper
• 1,25-Dihydroxyvitamin D3 and the aging-related forkhead box O and sestrin proteins in osteoblasts.

  2013cites this paper
• Control of bone resorption in mice by Schnurri-3

  2012cites this paper
• Regulation of mouse Cyp24a1 expression via promoter-proximal and downstream-distal enhancers highlights new concepts of 1,25-dihydroxyvitamin D(3) action.

  2012cites this paper
• MKP-1 is essential for canonical vitamin D-induced signaling through nuclear import and regulates RANKL expression and function.

  2012cites this paper
• Regulatory T cells: banned cells for decades.

  2012cites this paper
• Epigenetic regulation by nuclear receptors.

  2011cites this paper
• What is a functional locus? Understanding the genetic basis of complex phenotypic traits.

  2011cites this paper
• Multifunctional enhancers regulate mouse and human vitamin D receptor gene transcription.

  2010cites this paper
• Genome-wide analysis of the VDR/RXR cistrome in osteoblast cells provides new mechanistic insight into the actions of the vitamin D hormone.

  2010cites this paper
• Diversity of Vitamin D Target Genes

  2010cites this paper
• Curcumin: a novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention.

  2010cites this paper
• 1,25-DIHYDROXYVITAMIN D3-INDUCED GENES IN OSTEOBLASTS: UNCOVERING NEW FUNCTIONS FOR MENINGIOMA 1 AND SEMAPHORIN 3B IN SKELETAL PHYSIOLOGY

  2009cites this paper
• Regulation of cutaneous immunity by the environment: an important role for UV irradiation and vitamin D.

  2009cites this paper
• Modulation of mouse RANKL gene expression by Runx2 and vitamin D3

  2008influential citation
• adjacent binding on a genome-wide scale and C / EBP factors orchestrate adipocyte biology via γ PPAR Material Supplemental

  2008cites this paper
• KUOPION YLIOPISTON JULKAISUJA C. LUONNONTIETEET JA YMPÄRISTÖTIETEET 246 KUOPIO UNIVERSITY PUBLICATIONS C. NATURAL AND ENVIRONMENTAL SCIENCES 246

  2008cites this paper
• PPAR (cid:1) and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale

  2008cites this paper
• The expression of the human apolipoprotein genes and their regulation by PPARs

  2008cites this paper
• Metabolic Pathways of Type 2 Diabetes Intersection of Genetics, Transcriptomics, and Metabolite Profiling

  2008cites this paper
• Nuclear receptor location analyses in mammalian genomes: from gene regulation to regulatory networks.

  2008cites this paper
• PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale.

  2008cites this paper