Intronic ANG II type 2 receptor gene polymorphism 1675 G/A modulates receptor protein expression but not mRNA splicing.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  American Journal of Physiology. Regulatory Integrative and Comparative Physiology

• Publication date

  2005-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/AJPREGU.00385.2005PMID 16109806
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Effect of the angiotensin II type 2-receptor gene (+1675 G/A) on left ventricular structure in humans.

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• Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT2) angiotensin receptor.

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• Role of type 1 and type 2 angiotensin receptors in angiotensin II-induced cardiomyocyte hypertrophy.

  1996cited by this paper
• Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice

  1996cited by this paper
• The sequence and genomic organization of the human type 2 angiotensin II receptor.

  1995cited by this paper
• Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice

  1995cited by this paper
• Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor

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• The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer.

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• The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells.

  1995cited by this paper
• Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice.

  1995cited by this paper
• Pre-mRNA splicing.

  1994cited by this paper
• Role of angiotensin subtype 2 receptor in neointima formation after vascular injury.

  1992cited by this paper
• The generality of self-splicing RNA: Relationship to nuclear mRNA splicing

  1986cited by this paper
• Pre-mRNA splicing.

  1986cited by this paper
• The generality of self-splicing RNA: relationship to nuclear mRNA splicing.

  1986cited by this paper
• Cryptic branch point activation allows accurate in vitro splicing of human beta-globin intron mutants.

  1985cited by this paper
• The smooth muscle cell in culture.

  1979cited by this paper
• Splicing and the formation of stable RNA.

  1979cited by this paper

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