MC1R and cAMP signaling inhibit cdc25B activity and delay cell cycle progression in melanoma cells

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2013-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.1201917110PMID 23908401PMCID PMC3752210
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A UV-independent pathway to melanoma carcinogenesis in the redhair-fairskin background

  2012cited by this paper
• An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair / fair skin background

  2012cited by this paper
• ERK and PDE4 cooperate to induce RAF isoform switching in melanoma

  2011cited by this paper
• Protein kinase A regulates resumption of meiosis by phosphorylation of Cdc25B in mammalian oocytes

  2009cited by this paper
• α‐MSH activates immediate defense responses to UV‐induced oxidative stress in human melanocytes

  2009cited by this paper
• MAPK Pathway Activation Delays G2/M Progression by Destabilizing Cdc25B*

  2009cited by this paper
• Protein kinase a modulates Cdc25B activity during meiotic resumption of mouse oocytes

  2008cited by this paper
• Central role of p53 in the suntan response and pathologic hyperpigmentation.

  2007cited by this paper
• Melanocortin 1 receptor variants and skin cancer risk

  2006cited by this paper
• MC1R germline variants confer risk for BRAF-mutant melanoma.

  2006cited by this paper
• Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning

  2006cited by this paper
• In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling.

  2006cited by this paper
• Comprehensive evaluation of allele frequency differences of MC1R variants across populations.

  2006cited by this paper
• Meta-analysis of risk factors for cutaneous melanoma: III. Family history, actinic damage and phenotypic factors.

  2005cited by this paper
• Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways

  2005cited by this paper
• Activation of the cAMP pathway by variant human MC1R alleles expressed in HEK and in melanoma cells.

  2005cited by this paper
• Protein Kinase A Blocks Raf-1 Activity by Stimulating 14-3-3 Binding and Blocking Raf-1 Interaction with Ras*

  2003cited by this paper
• The role of melanocortin-1 receptor polymorphism in skin cancer risk phenotypes.

  2003cited by this paper
• Regulating mammalian checkpoints through Cdc25 inactivation

  2003cited by this paper
• Inhibition of Xenopus oocyte meiotic maturation by catalytically inactive protein kinase A

  2002cited by this paper
• Loss-of-function variants of the human melanocortin-1 receptor gene in melanoma cells define structural determinants of receptor function.

  2002cited by this paper
• Cyclic AMP Blocks Cell Growth through Raf-1-Dependent and Raf-1-Independent Mechanisms

  2002cited by this paper
• Melanocortin 1 receptor (MC1R) gene variants are associated with an increased risk for cutaneous melanoma which is largely independent of skin type and hair color.

  2001cited by this paper
• Cdc25B activity is regulated by 14-3-3

  2001cited by this paper
• Cell cycle regulation by the Cdc25 phosphatase family.

  2000cited by this paper
• Ras mediates the cAMP‐dependent activation of extracellular signal‐regulated kinases (ERKs) in melanocytes

  2000cited by this paper
• The melanocortin-1 receptor is a key regulator of human cutaneous pigmentation.

  2000cited by this paper
• Melanoma and sun exposure: An overview of published studies

  1997cited by this paper
• The Asp84Glu variant of the melanocortin 1 receptor (MC1R) is associated with melanoma.

  1996cited by this paper
• Variants of the melanocyte–stimulating hormone receptor gene are associated with red hair and fair skin in humans

  1995cited by this paper
• Alpha melanocyte stimulating hormone (alpha MSH) stimulates normal human melanocyte growth by binding to high-affinity receptors.

  1993cited by this paper
• MUTATION IN BRIEF

  year unknowncited by this paper

• MC1R depalmitoylation inhibition reveals a physiological role for pheomelanin

  2026cites this paper
• Spectrum of Phenotypes Associated with Human MC1R Variations

  2025cites this paper
• A pathological role of O-GlcNAcylation-driven TR11B production and function in lung adenocarcinoma.

  2025cites this paper
• Understanding Mechanisms and Key Factors Influencing Melanogenesis for the Management of Melasma: An Updated Review.

  2024cites this paper
• MC1R signaling through the cAMP-CREB/ATF-1 and ERK-NFκB pathways accelerates G1/S transition promoting breast cancer progression

  2023cites this paper
• The Role of Cyclic Adenosine Monophosphate (cAMP) in Modulating Glucocorticoid Receptor Signaling and Its Implications on Glucocorticoid-Related Collagen Loss

  2023cites this paper
• A Side-by-Side Comparison of Wildtype and Variant Melanocortin 1 Receptor Signaling with Emphasis on Protection against Oxidative Damage to DNA

  2023cites this paper
• Targeting GPCRs and Their Signaling as a Therapeutic Option in Melanoma

  2022cites this paper
• Lipid droplets are a metabolic vulnerability in melanoma

  2022cites this paper
• Role of miRNAs in melanin metabolism: Implications in melanin‐related diseases

  2022cites this paper
• A nuclear cAMP microdomain suppresses tumor growth by Hippo pathway inactivation

  2021cites this paper
• Carvone Decreases Melanin Content by Inhibiting Melanoma Cell Proliferation via the Cyclic Adenosine Monophosphate (cAMP) Pathway

  2020cites this paper
• Cyclic adenosine monophosphate (cAMP) signaling in melanocyte pigmentation and melanomagenesis

  2020cites this paper
• Circular RNA hsa_circRNA_102958 promotes tumorigenesis of colorectal cancer via miR-585/CDC25B axis

  2019cites this paper
• Identification of differentially expressed genes and functional annotations associated with metastases of the uveal melanoma

  2019cites this paper
• Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism and in Vitro Efficacy against Melanoma Cell Lines.

  2019cites this paper
• TNFα-signal and cAMP-mediated signals oppositely regulate melanoma- associated ganglioside GD3 synthase gene in human melanocytes

  2019cites this paper
• Circular RNA hsa_circRNA_102958 promotes tumorigenesis of colorectal cancer via miR-585/ CDC25B axis

  2019cites this paper
• Targeted therapies in melanoma beyond BRAF: targeting NRAS-mutated and KIT-mutated melanoma.

  2019cites this paper
• Circular RNA hsa_circRNA_102958 promotes tumorigenesis of colorectal cancer via miR-585/ CDC25B axis

  2019cites this paper
• Finasteride inhibits melanogenesis through regulation of the adenylate cyclase in melanocytes and melanoma cells

  2018cites this paper
• Adenosine and adenosine receptors in the immunopathogenesis and treatment of cancer

  2018cites this paper
• A meta-analysis of transcriptome datasets characterizes malignant transformation from melanocytes and nevi to melanoma.

  2018cites this paper
• Melanoma‐associated GRM3 variants dysregulate melanosome trafficking and cAMP signaling

  2018cites this paper
• PDE4D promotes FAK-mediated cell invasion in BRAF-mutated melanoma

  2017cites this paper
• EPAC–RAP1 Axis-Mediated Switch in the Response of Primary and Metastatic Melanoma to Cyclic AMP

  2017influential citation
• Detrimental effects of melanocortin‐1 receptor (MC1R) variants on the clinical outcomes of BRAF V600 metastatic melanoma patients treated with BRAF inhibitors

  2016cites this paper
• Oxidative stress-induced DNA damage of mouse zygotes triggers G2/M checkpoint and phosphorylates Cdc25 and Cdc2

  2016cites this paper
• Specific Activation of A3, A2A and A1 Adenosine Receptors in CD73-Knockout Mice Affects B16F10 Melanoma Growth, Neovascularization, Angiogenesis and Macrophage Infiltration

  2016cites this paper
• Melanocortin Peptide Drug Design and Application to Feeding Behavior and Melanoma

  2015cites this paper
• MicroRNA-211, a direct negative regulator of CDC25B expression, inhibits triple-negative breast cancer cells’ growth and migration

  2015cites this paper
• Diverse effects of cAMP signaling in melanoma support the role of distinct cAMP microdomains in melanomagenesis, metastasis, and resistance to therapy

  2014cites this paper
• Resistance to MAPK inhibition: come see(c) AMPed up melanoma

  2014cites this paper
• Melanocytes as Instigators and Victims of Oxidative Stress

  2014cites this paper
• Cyclic AMP (cAMP) signaling in melanocytes and melanoma.

  2014cites this paper