Promoting effects of unleaded gasoline and 2,2,4-trimethylpentane on the development of atypical cell foci and renal tubular cell tumors in rats exposed to N-ethyl-N-hydroxyethylnitrosamine.

No abstract is available for this paper.

• Publication year

  1989

• Venue

  Cancer Research

• Publication date

  1989-11-15

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  PMID 2804983
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Exposures associated with cancer in humans

  2004cited by this paper
• Elevated proliferation of proximal tubule cells and localization of accumulated alpha 2u-globulin in F344 rats during chronic exposure to unleaded gasoline or 2,2,4-trimethylpentane.

  1989influential reference
• The comparative pathobiology of alpha 2u-globulin nephropathy.

  1989cited by this paper
• Potential role of alpha-2 mu-globulin, protein droplet accumulation, and cell replication in the renal carcinogenicity of rats exposed to trichloroethylene, perchloroethylene, and pentachloroethane.

  1988cited by this paper
• High- to low-dose extrapolation: critical determinants involved in the dose response of carcinogenic substances.

  1987cited by this paper
• Site-specific renal cytotoxicity and cell proliferation in male rats exposed to petroleum hydrocarbons.

  1987influential reference
• Reciprocal modifying effects of isomeric forms of aminophenol on induction of neoplastic lesions in rat liver and kidney initiated by N-ethyl-N-hydroxyethylnitrosamine.

  1987cited by this paper
• Experimental induction of renal tumors.

  1987cited by this paper
• Assessment of unscheduled and replicative DNA synthesis in rat kidney cells exposed in vitro or in vivo to unleaded gasoline.

  1987cited by this paper
• Immunohistochemically demonstrated altered expression of cytochrome P-450 molecular forms and epoxide hydrolase in N-ethyl-N-hydroxyethylnitrosamine-induced rat kidney and liver lesions.

  1987cited by this paper
• Rat renal carcinogenesis after chronic simultaneous exposure to lead acetate and N-nitrosodiethylamine

  1987cited by this paper
• Accumulation of alpha 2u-globulin in the renal proximal tubules of male rats exposed to unleaded gasoline.

  1987cited by this paper
• Correlative histochemical studies on preneoplastic and neoplastic lesions in the kidney of rats treated with nitrosamines

  1986cited by this paper
• Preneoplastic lesions as end points in carcinogenicity testing. II. Preneoplasia in various non-hepatic tissues.

  1986cited by this paper
• Renal oncocytoma: origin from the collecting duct

  1986cited by this paper
• Assessment of unscheduled and replicative DNA synthesis in hepatocytes treated in vivo and in vitro with unleaded gasoline or 2,2,4-trimethylpentane.

  1986cited by this paper
• Alpha 2U-globulin: measurement in rat kidney following administration of 2,2,4-trimethylpentane.

  1986cited by this paper
• Histopathology and Cell Proliferation Induced by 2,2,4-Trimethylpentane in the Male Rat Kidney

  1986cited by this paper
• Assessment of the genotoxic potential of unleaded gasoline and 2,2,4-trimethylpentane in human lymphoblasts in vitro.

  1986cited by this paper
• Comparison of the various forms of glutathione S-transferase with glucose-6-phosphate dehydrogenase and gamma-glutamyltranspeptidase as markers of preneoplastic and neoplastic lesions in rat kidney induced by N-ethyl-N-hydroxyethylnitrosamine.

  1985cited by this paper
• Dose-related effect of trisodium nitrilotriacetate monohydrate on renal tumorigenesis initiated with N-ethyl-N-hydroxyethylnitrosamine in rats.

  1985cited by this paper
• Dose-related enhancing effect of potassium bromate on renal tumorigenesis in rats initiated with N-ethyl-N-hydroxyethyl-nitrosamine.

  1985cited by this paper
• Promoting Effect of Metal Compounds on Rat Renal Tumorigenesis

  1985cited by this paper
• Chronic kidney disease and organic chemical exposures: evaluations of causal relationships in humans and experimental animals.

  1984cited by this paper
• Trisodium nitrilotriacetate monohydrate: promoting effects on the development of renal tubular cell tumors in rats treated with N-ethyl-N-hydroxyethylnitrosamine.

  1984cited by this paper
• DL-Serine: promoting activity on renal tumorigenesis by N-ethyl-N-hydroxyethylnitrosamine in rats.

  1984cited by this paper
• Natural history of body weight gain, survival, and neoplasia in the F344 rat.

  1984cited by this paper
• Promotion of 2-(ethylnitrosamino)ethanol-induced renal carcinogenesis in rats by nephrotoxic compounds: positive responses with folic acid, basic lead acetate, and N-(3,5-dichlorophenyl)succinimide but not with 2,3-dibromo-1-propanol phosphate.

  1984cited by this paper
• Modulation of chemical carcinogenesis by xenobiotics.

  1984cited by this paper
• Distinction between liver neoplasm promoting and syncarcinogenic effects demonstrated by exposure to phenobarbital or diethylnitrosamine either before or after N-2-fluorenylacetamide.

  1984cited by this paper
• A Chronic Inhalation Study with Unleaded Gasoline Vapor

  1984cited by this paper
• Renal effects of petroleum hydrocarbons

  1984cited by this paper
• Chronic Kidney Disease and Organic Chemical Exposures: Evaluations of Causal Relationships in Humans and Experimental Animals

  1984cited by this paper
• Sequential observations on the appearance of neoplastic lesions in the liver and kidney after treatment with N-ethyl-N-hydroxyethylnitrosamine followed by partial hepatectomy and unilateral nephrectomy.

  1983cited by this paper
• Basic lead acetate: promoting effect on the development of renal tubular cell tumors in rats treated with N-ethyl-N-hydroxyethylnitrosamine.

  1983cited by this paper
• The Cell Cycle and Chemical Carcinogenesis

  1983cited by this paper
• Enhancement by potassium bromate of renal tumorigenesis initiated by N-ethyl-N-hydroxyethylnitrosamine in F-344 rats.

  1983cited by this paper
• Gamma glutamyl transpeptidase activity in carcinogen-induced epithelial lesions of rat kidney.

  1982cited by this paper
• Metabolic activation of chemical carcinogens by kidney from rats and mice of various ages.

  1982cited by this paper
• Effect of phenobarbital, polychlorinated biphenyl and sodium saccharin on hepatic and renal carcinogenesis in unilaterally nephrectomized rats given N-ethyl-N-hydroxyethylnitrosamine orally.

  1981cited by this paper
• Adenocarcinoma of the kidney. IV. Electron microscopic study of the development of renal adenocarcinomas induced in rats by N-(4'-fluoro-4-biphenylyl)acetamide.

  1980cited by this paper
• The stages of initiation and promotion in hepatocarcinogenesis.

  1980cited by this paper
• Adenocarcinoma of the kidney. III. Histogenesis of renal adenocarcinomas induced in rats by N-(4'-fluoro-4-biphenylyl)acetamide.

  1980cited by this paper
• Improved methodology for generating controlled test atmospheres.

  1980cited by this paper
• Neoplastic and nonneoplastic lesions in aging F344 rats.

  1979cited by this paper
• Histopathological studies on renal tubular cell tumors in rats treated with N-ethyl-N-hydroxyethylnitrosamine.

  1979cited by this paper
• Age-associated pathological changes in male rats.

  1978cited by this paper
• Adenocarcinoma of the kidney. I. Ultrastructure of renal adenocarcinomas induced in rats by N-(4'-fluoro-4-biphenylyl)acetamide.

  1976cited by this paper
• Tumours of the kidney, renal pelvis and ureter.

  1976cited by this paper
• Renal epithelial dysplasia and neoplasia in rats given dimethylnitrosamine

  1972cited by this paper
• Ultrastructural aspects of renal adenocarcinoma induced in the rat by dimethylnitrosamine.

  1971cited by this paper
• Morphogenesis of epithelial neoplasms induced in the rat kidney by dimethylnitrosamine.

  1971cited by this paper
• Animal inhalation exposure chambers.

  1968cited by this paper
• SOME BIOLOGICAL ASPECTS OF SKIN CARCINOGENISIS.

  1964cited by this paper
• Principles and procedures of statistics.

  1961cited by this paper
• Animal inhalation exposure chambers.

  1959cited by this paper
• The Mechanism of Carcinogenesis. A Study of the Significance of Cocarcinogenic Action and Related Phenomena

  1941cited by this paper

• Adverse outcome pathway (AOP): α2u-globulin nephropathy and kidney tumors in male rats

  2022cites this paper
• Les particules diesel : impact sur la santé et moyens de lutte en France

  2017cites this paper
• Biochemical and physiological effects from exhaust emissions. A review of the relevant literature.

  2016cites this paper
• SAFETY DATA SHEET 1. INFORMATION

  2015cites this paper
• Mammalian models of chemically induced primary malignancies exploitable for imaging-based preclinical theragnostic research.

  2015cites this paper
• Trimethylpentane (all isomers)

  2014influential citation
• Safety Assessment of Isoparaffins as Used in Cosmetics

  2012cites this paper
• α2u-Globulin Nephropathy

  2010cites this paper
• Chemical and physical properties of the pure substance

  2008cites this paper
• A possible role for cell proliferation in potassium bromate (KBrO3) carcinogenesis

  2005cites this paper
• RISK CHARACTERIZATION: PRINCIPLES AND PRACTICE

  2002cites this paper
• Lack of oxidative DNA damage or initiation of carcinogenesis in the kidneys of male F344 rats given subchronic exposure to p-dichlorobenzene (pDCB)at a carcinogenic dose

  2000cites this paper
• Mortality among three refinery/petrochemical plant cohorts. I. 1970 to 1982 active/terminated workers.

  2000cites this paper
• 2-Methylpentane (isohexane). CAS# 107-83-5.

  1999cites this paper
• A physiological model for ligand-induced accumulation of alpha 2u globulin in male rat kidney: roles of protein synthesis and lysosomal degradation in the renal dosimetry of 2,4,4-trimethyl-2-pentanol.

  1999cites this paper
• Species Differences in Thyroid, Kidney and Urinary Bladder Carcinogenesis

  1999cites this paper
• 2-METHYLPENTANE (ISOHEXANE)

  1999cites this paper
• Exfoliated Cells in the Urine Reflect Transient and Sustained Elevation of Cell Proliferation in Rat α2u-Globulin Nephropathy

  1999cites this paper
• alpha 2-Urinary globulin-associated nephropathy as a mechanism of renal tubule cell carcinogenesis in male rats.

  1999cites this paper
• 2,3-Dimethylbutane. CAS# 79-29-8.

  1999cites this paper
• Effect of Hexachloro-1,3-butadiene on Renal Carcinogenesis in Male Rats Pretreated with N-Ethyl-N-hydroxyethylnitrosamine

  1998cites this paper
• Oxidative DNA damage and cell proliferation in kidneys of male and female rats during 13-weeks exposure to potassium bromate (KBrO3)

  1998cites this paper
• The Progression of Neoplasia, Cell Replication, and Electromagnetic Fields

  1998cites this paper
• 1,3,5-Trinitrobenzene-Induced Alpha-2u-Globulin Nephropathy

  1997cites this paper
• Carcinogenicity of Gasoline: A Review of Epidemiological Evidence

  1997cites this paper
• Relationship of Hydroquinone-Associated Rat Renal Tumors with Spontaneous Chronic Progressive Nephropathy

  1997cites this paper
• Doubting nongenotoxic mechanisms of renal cancer: comparing apples and oranges in the alpha2u-globulin hypothesis.

  1997cites this paper
• Binding of hexachlorobutadiene to alpha 2u-globulin and its role in nephrotoxicity in rats.

  1997cites this paper
• Binding of Hexachlorobutadiene to α2u-Globulin and Its Role in Nephrotoxicity in Rats

  1997cites this paper
• Doubting nongenotoxic mechanisms of renal cancer: comparing apples and oranges in the alpha2u-globulin hypothesis.

  1997cites this paper
• Implications for risk assessment of suggested nongenotoxic mechanisms of chemical carcinogenesis.

  1996influential citation
• Toxicology in Transition

  1995cites this paper
• A possible role for oxidative stress in potassium bromate (KBrO3) carcinogenesis.

  1995cites this paper
• Synergism and Antagonism Between Chemical Carcinogens

  1995cites this paper
• Toxicological profile for gasoline

  1995cites this paper
• Development of a mechanism-based dosimetry model for 2,4,4-trimethyl-2-pentanol-induced alpha 2u-globulin nephropathy in male Fischer 344 rats.

  1995cites this paper
• Preneoplastic Lesions In Kidney And Carcinogenesis By Non-Genotoxic Compounds

  1994cites this paper
• Preneoplastic lesions in kidney and carcinogenesis by non-genotoxic compounds.

  1994cites this paper
• Comparative hyaline droplet nephropathy in male F344/NCr rats induced by sodium barbital and diethylacetylurea, a breakdown product of sodium barbital.

  1994cites this paper
• α 2μ -Globulin Mediated Male Rat Kidney Carcinogenesis

  1994cites this paper
• Interpretation of male rat renal tubule tumors.

  1993cites this paper
• Hazard evaluation of chemicals that cause accumulation of alpha 2u-globulin, hyaline droplet nephropathy, and tubule neoplasia in the kidneys of male rats.

  1993cites this paper
• ACCELERATED DEVELOPMENT OF CHRONIC PROGRESSIVE NEPHROSIS IN MALE F344 RATS AFTER CESSATION OF PDICHLOROBENZENE-TREATMENT

  1993cites this paper
• Alpha 2u-globulin nephropathy: review of the cellular and molecular mechanisms involved and their implications for human risk assessment.

  1993cites this paper
• Modification of hepato- and renal carcinogenesis by catechol and its isomers in rats pretreated with N-ethyl-N-hydroxyethylnitrosamine.

  1993cites this paper
• Cell proliferation and renal carcinogenesis.

  1993cites this paper
• Kidney cancer and hydrocarbon exposures among petroleum refinery workers.

  1993cites this paper
• Critique of R. Melnick's "An alternative hypothesis on the role of chemically induced protein droplet (alpha 2u-globulin) nephropathy in renal carcinogenesis".

  1993cites this paper
• Hepatocyte cell proliferation in mice after inhalation exposure to unleaded gasoline vapor.

  1993cites this paper
• A comparison of European High Test gasoline and PS-6 unleaded gasoline in their abilities to induce alpha 2u-globulin nephropathy and renal cell proliferation.

  1992cites this paper
• Mechanisms of Xenobiotic-lnduced Renal Carcinogenicity

  1992cites this paper
• Evaluation of genotoxicity, pathological lesions, and cell proliferation in livers of rats and mice treated with furan

  1992cites this paper
• Species-specific mechanisms of carcinogenesis.

  1992cites this paper
• An alternative hypothesis on the role of chemically induced protein droplet (alpha 2u-globulin) nephropathy in renal carcinogenesis.

  1992cites this paper
• Preneoplastic lesions in rodent kidney induced spontaneously or by non-genotoxic agents: predictive nature and comparison to lesions induced by genotoxic carcinogens.

  1991cites this paper
• The Presence of α2u-Globulin Is Necessary for d-Limonene Promotion of Male Rat Kidney Tumors

  1991cites this paper
• The human relevance of the renal tumor-inducing potential of d-limonene in male rats: implications for risk assessment.

  1991cites this paper
• The presence of alpha 2u-globulin is necessary for d-limonene promotion of male rat kidney tumors.

  1991cites this paper
• NCI-Black-Reiter (NBR) male rats fail to develop renal disease following exposure to agents that induce α-2u-globulin (α2u) nephropathy☆

  1991cites this paper
• Induction of Renal Cell Tumors in Rats and Mice, and Enhancement of Hepatocellular Tumor Development in Mice after Long‐term Hydroquinone Treatment

  1991cites this paper
• Characteristics of chemical binding to alpha 2u-globulin in vitro--evaluating structure-activity relationships.

  1991cites this paper
• Alpha 2u-globulin nephropathy without nephrocarcinogenesis in male Wistar rats administered 1-(aminomethyl)cyclohexaneacetic acid.

  1991cites this paper
• NCI-Black-Reiter (NBR) male rats fail to develop renal disease following exposure to agents that induce alpha-2u-globulin (alpha 2u) nephropathy.

  1991cites this paper
• Chronic nephrotoxicity of 2,2,4-trimethylpentane and other branched-chain hydrocarbons.

  1990cites this paper
• Biochemical mechanisms and pathobiology of alpha 2u-globulin nephropathy.

  1990cites this paper
• Consideration of both genotoxic and nongenotoxic mechanisms in predicting carcinogenic potential.

  1990cites this paper
• Nephrocarcinogenic xenobiotics.

  1990cites this paper
• Involvement of reversible binding to α2u-globulin in 1,4-dichlorobenzene-induced nephrotoxicity☆

  1989cites this paper