Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  International Journal of Biochemistry and Cell Biology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.biocel.2008.03.008PMID 18436469
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases.

  2008cited by this paper
• HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention

  2007cited by this paper
• DNA Damage-Induced Acetylation of Lysine 3016 of ATM Activates ATM Kinase Activity

  2007cited by this paper
• Acetylation of MEK2 and IκB kinase (IKK) activation loop residues by YopJ inhibits signaling

  2006cited by this paper
• Acetylation of MEK2 and I kappa B kinase (IKK) activation loop residues by YopJ inhibits signaling.

  2006cited by this paper
• Poly(ADP-ribose) polymerase-2 contributes to the fidelity of male meiosis I and spermiogenesis

  2006cited by this paper
• Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?

  2006cited by this paper
• Poly(ADP-ribose): novel functions for an old molecule

  2006cited by this paper
• Poly(ADP-ribose) polymerase-1 activation during DNA damage and repair.

  2006cited by this paper
• Acetylation of Poly(ADP-ribose) Polymerase-1 by p300/CREB-binding Protein Regulates Coactivation of NF-κB-dependent Transcription*

  2005cited by this paper
• A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.

  2005cited by this paper
• The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases.

  2004cited by this paper
• Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis.

  2004cited by this paper
• Noncleavable poly(ADP-ribose) polymerase-1 regulates the inflammation response in mice.

  2004cited by this paper
• The Sir2 family of protein deacetylases.

  2004cited by this paper
• Lysine acetylation and the bromodomain: a new partnership for signaling

  2004cited by this paper
• Functional interaction between PARP‐1 and PARP‐2 in chromosome stability and embryonic development in mouse

  2003cited by this paper
• Mechanisms of P/CAF auto-acetylation.

  2003cited by this paper
• Transcriptional Coactivation of Nuclear Factor-κB-dependent Gene Expression by p300 Is Regulated by Poly(ADP)-ribose Polymerase-1*

  2003cited by this paper
• Poly(ADP-ribose) Polymerase-2 (PARP-2) Is Required for Efficient Base Excision DNA Repair in Association with PARP-1 and XRCC1*

  2002cited by this paper
• Acetylation regulates the DNA end-trimming activity of DNA polymerase beta.

  2002cited by this paper
• Cooperation between complexes that regulate chromatin structure and transcription.

  2002cited by this paper
• Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300.

  2001cited by this paper
• Acetylation and chromosomal functions.

  2000cited by this paper
• SAP - a putative DNA-binding motif involved in chromosomal organization.

  2000cited by this paper
• Acetylation of Histones and Transcription-Related Factors

  2000cited by this paper
• Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions.

  1999cited by this paper
• PARP-2, A Novel Mammalian DNA Damage-dependent Poly(ADP-ribose) Polymerase*

  1999cited by this paper
• A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues.

  1999cited by this paper
• The mechanism of the elongation and branching reaction of poly(ADP-ribose) polymerase as derived from crystal structures and mutagenesis.

  1998cited by this paper
• Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo.

  1998cited by this paper
• Human histone acetyltransferase GCN5 exists in a stable macromolecular complex lacking the adapter ADA2.

  1997cited by this paper
• Random mutagenesis of the poly(ADP-ribose) polymerase catalytic domain reveals amino acids involved in polymer branching.

  1997cited by this paper
• Histone acetyltransferase activity and interaction with ADA2 are critical for GCN5 function in vivo

  1997cited by this paper
• ADP-ribose in glycation and glycoxidation reactions.

  1997cited by this paper
• Regulation of NF-κB by Cyclin-Dependent Kinases Associated with the p300 Coactivator

  1997cited by this paper
• The transcriptional coactivators p300 and CBP are histone acetyltransferases.

  1996cited by this paper
• A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

  1996cited by this paper
• Glycation and Glycoxidation of Histones by ADP-ribose (*)

  1996cited by this paper
• Role of Glutamic Acid 988 of Human Poly-ADP-ribose Polymerase in Polymer Formation

  1995cited by this paper
• Protein glycation by ADP-ribose: studies of model conjugates.

  1993cited by this paper

• GCN5L: a critical target in energy metabolism pathways

  2025cites this paper
• Specific and shared biological functions of PARP2 – is PARP2 really a lil’ brother of PARP1?

  2024cites this paper
• Lysine Acetylation, Cancer Hallmarks and Emerging Onco-Therapeutic Opportunities

  2022cites this paper
• Multi-therapies Based on PARP Inhibition: Potential Therapeutic Approaches for Cancer Treatment.

  2022cites this paper
• Lysine Acetylation in the Proteome of Renal Tubular Epithelial Cells in Diabetic Nephropathy

  2021cites this paper
• Poly(ADP-ribose) polymerase-2 is essential for endometrial receptivity and blastocyst implantation, and regulated by caspase-8.

  2020cites this paper
• Silencing of PARP2 Blocks Autophagic Degradation

  2020influential citation
• Role of PARP-catalyzed ADP-ribosylation in the crosstalk between DNA strand breaks and epigenetic regulation.

  2019influential citation
• Poly(ADP-ribose) polymerase-2 is a lipid-modulated modulator of muscular lipid homeostasis.

  2018cites this paper
• Nuclear Import of Arabidopsis Poly(ADP-Ribose) Polymerase 2 Is Mediated by Importin-α and a Nuclear Localization Sequence Located Between the Predicted SAP Domains

  2018cites this paper
• Poly(ADP-Ribose) polymerase 1 as a key regulator of DNA repair

  2016cites this paper
• Characterization of the DNA dependent activation of human ARTD2/PARP2

  2016cites this paper
• Post-translational modifications in mitochondria: protein signaling in the powerhouse

  2016cites this paper
• Understanding specific functions of PARP-2: new lessons for cancer therapy.

  2016cites this paper
• PARPs and ADP-Ribosylation: 50 Years … and Counting.

  2015cites this paper
• Nuclear ADP-Ribosylation and Its Role in Chromatin Plasticity, Cell Differentiation, and Epigenetics.

  2015cites this paper
• PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage

  2015cites this paper
• Quantitative site-specific ADP-ribosylation profiling of DNA-dependent PARPs.

  2015cites this paper
• The Role of PARP-1 in Host-Pathogen Interaction and Cellular Stress Responses.

  2015cites this paper
• Interplay between histone acetylation/deacetylation and poly(ADP-ribosyl)ation in the development of ischemic tolerance in vitro.

  2015cites this paper
• Deletion of PARP-2 induces hepatic cholesterol accumulation and decrease in HDL levels.

  2014cites this paper
• Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling

  2014cites this paper
• MicroRNA-149 Inhibits PARP-2 and Promotes Mitochondrial Biogenesis via SIRT-1/PGC-1α Network in Skeletal Muscle

  2014cites this paper
• Probing PARP1-inhibitor complexes for the development of novel inhibitors.

  2014cites this paper
• Alpha-lipoic acid attenuates cardiac hypertrophy via downregulation of PARP-2 and subsequent activation of SIRT-1.

  2014cites this paper
• The Role of Poly(ADP-ribosyl)ation in DNA Damage Response and Cancer Chemotherapy

  2014cites this paper
• PARP-1 activation regulates the DNA damage response to DNA double-strand breaks

  2014cites this paper
• Characterization of the mono-ADP-ribosylation by ARTD10 : substrates, consequences and reversibility

  2014cites this paper
• Assessment of Unique and Combined Functions of Poly(ADP-Ribose) Polymerases by Using RNA Interference

  2014cites this paper
• PARP-2 regulates cell cycle-related genes through histone deacetylation and methylation independently of poly(ADP-ribosyl)ation.

  2013cites this paper
• Poly(ADP-ribose): PARadigms and PARadoxes.

  2013cites this paper
• Interaction of PARP-2 with DNA structures mimicking DNA repair intermediates and consequences on activity of base excision repair proteins.

  2013cites this paper
• Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes.

  2013cites this paper
• Macrodomain-containing proteins: regulating new intracellular functions of mono(ADP-ribosyl)ation

  2013cites this paper
• Expanding functions of intracellular resident mono‐ADP‐ribosylation in cell physiology

  2013cites this paper
• Mapping PARP-1 auto-ADP-ribosylation sites by liquid chromatography-tandem mass spectrometry.

  2013cites this paper
• Molecular mechanisms in inherited retinal degeneration: Exploring three routes towards understanding Retinitis pigmentosa

  2013cites this paper
• Poly(ADP) Ribose Polymerase at the Interface of DNA Damage Signaling and DNA Repair

  2013cites this paper
• Data-independent mass spectrometry strategies for the identification of atRA-mediated protein signatures of differential cellular response

  2013cites this paper
• Identification de nouveaux partenaires protéiques de l'oncoprotéine Ets-1 et étude de sa régulation par l'enzyme de réparation de l'ADN PARP-1 au sein des cellules tumorales

  2013cites this paper
• Regulacija apoptoze pod utjecajem poli[ADP-riboza] polimeraze-1

  2012cites this paper
• FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ( Ph . D . ) Role of poly ( ADP-ribose ) polymerase ( PARP )-2 in mitochondrial metabolism and in doxorubicin-induced vascular damage by Magdolna Szántó

  2012influential citation
• On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1.

  2012influential citation
• HDAC inhibition prevents Rd1 mouse photoreceptor degeneration.

  2012cites this paper
• Poly(ADP-ribose) polymerase-2: emerging transcriptional roles of a DNA-repair protein

  2012cites this paper
• Synthesis and SAR optimization of quinazolin-4(3H)-ones as poly(ADP-ribose)polymerase-1 inhibitors.

  2012cites this paper
• Characterization and Prediction of Lysine (K)-Acetyl-Transferase Specific Acetylation Sites*

  2011cites this paper
• Characterization and Prediction of Lysine (K)- Acetyl-Transferase Specific Acetylation Sites*□S

  2011cites this paper
• PARP-2 regulates SIRT1 expression and whole-body energy expenditure.

  2011cites this paper
• The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets.

  2010influential citation
• Excessive HDAC activation is critical for neurodegeneration in the rd1 mouse

  2010cites this paper
• Proteomique fonctionnelle des poly(ADP-Ribose) polymerases

  2010cites this paper
• Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding.

  2010cites this paper
• PARP1 ADP-ribosylates lysine residues of the core histone tails

  2010cites this paper
• PARP inhibitors: new tools to protect from inflammation.

  2010cites this paper
• Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging

  2009influential citation
• Disruption of Poly(ADP-Ribose) Homeostasis Affects Spermiogenesis and Sperm Chromatin Integrity in Mice1

  2009cites this paper
• Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites

  2009cites this paper
• Sumoylation of poly(ADP‐ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function

  2009cites this paper
• A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation

  2009cites this paper
• Importin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS

  2008cites this paper
• Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes

  2008cites this paper
• List of Papers Related Publications

  year unknowncites this paper