Long‐term macrolide treatment of chronic inflammatory airway diseases: risks, benefits and future developments

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Clinical and Experimental Allergy

• Publication date

  2012-09-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/j.1365-2222.2012.03979.xPMID 22925316
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effect of Azithromycin on Pulmonary Function in Patients With Cystic Fibrosis Uninfected With Pseudomonas aeruginosa: A Randomized Controlled Trial

  2012cited by this paper
• International Guidelines for the Treatment of Community-Acquired Pneumonia in Adults

  2012cited by this paper
• Clarithromycin inhibits interleukin-13-induced goblet cell hyperplasia in human airway cells.

  2011cited by this paper
• Azithromycin for prevention of exacerbations of COPD.

  2011influential reference
• Neomacrolides in the treatment of patients with severe asthma and/or bronchiectasis: a retrospective observational study

  2011cited by this paper
• Development of non-antibiotic macrolide that corrects inflammation-driven immune dysfunction in models of inflammatory bowel diseases and arthritis.

  2011cited by this paper
• Long-term low-dose erythromycin in patients with unexplained chronic cough: a double-blind placebo controlled trial

  2010cited by this paper
• British Thoracic Society guideline for non-CFbronchiectasis

  2010cited by this paper
• British Thoracic Society guideline for non-CF bronchiectasis

  2010cited by this paper
• A trial of clarithromycin for the treatment of suboptimally controlled asthma.

  2010cited by this paper
• Azithromycin induces anti-viral responses in bronchial epithelial cells

  2010cited by this paper
• A randomised controlled trial of azithromycin to prevent chronic rejection after lung transplantation

  2010influential reference
• Azithromycin is associated with increased survival in lung transplant recipients with bronchiolitis obliterans syndrome.

  2010influential reference
• Effect of azithromycin on pulmonary function in patients with cystic fibrosis uninfected with Pseudomonas aeruginosa: a randomized controlled trial.

  2010cited by this paper
• Mechanisms of Action and Clinical Application of Macrolides as Immunomodulatory Medications

  2010influential reference
• Macrolide-resistant Mycoplasma pneumoniae: characteristics of isolates and clinical aspects of community-acquired pneumonia

  2010cited by this paper
• Azithromycin and Clarithromycin Inhibit Lipopolysaccharide-Induced Murine Pulmonary Neutrophilia Mainly through Effects on Macrophage-Derived Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-1β

  2009cited by this paper
• Azithromycin reduces exaggerated cytokine production by M1 alveolar macrophages in cystic fibrosis.

  2009cited by this paper
• Aerosol Antibiotics in Cystic Fibrosis

  2009cited by this paper
• EM703, the new derivative of erythromycin, inhibits transcription of type I collagen in normal and scleroderma fibroblasts.

  2008cited by this paper
• Azithromycin alters macrophage phenotype.

  2008cited by this paper
• Long-term erythromycin therapy is associated with decreased chronic obstructive pulmonary disease exacerbations.

  2008cited by this paper
• New acylides: synthesis of 3-O-[γ-(4-oxo-2-aryl-thiazolidin-3-yl)butyryl]erythromycin A derivatives

  2008cited by this paper
• Azithromycin or montelukast as inhaled corticosteroid-sparing agents in moderate-to-severe childhood asthma study.

  2008cited by this paper
• Effects of prolonged use of azithromycin in patients with cystic fibrosis: a meta-analysis.

  2008cited by this paper
• EM703, A NEW DERIVATIVE OF ERYTHROMYCIN, INHIBITS TRANSFORMING GRWTH FACTOR-β SIGNALING IN HUMAN LUNG FIBROBLASTS

  2008cited by this paper
• Clarithromycin targets neutrophilic airway inflammation in refractory asthma.

  2008influential reference
• Azithromycin improves macrophage phagocytic function and expression of mannose receptor in chronic obstructive pulmonary disease.

  2008cited by this paper
• Azithromycin Blocks Quorum Sensing and Alginate Polymer Formation and Increases the Sensitivity to Serum and Stationary-Growth-Phase Killing of Pseudomonas aeruginosa and Attenuates Chronic P. aeruginosa Lung Infection in Cftr−/− Mice

  2007cited by this paper
• Azithromycin reduces bronchial hyperresponsiveness and neutrophilic airway inflammation in asthmatic children: a preliminary report.

  2007cited by this paper
• Lipopolysaccharide-induced lung inflammation is inhibited by neutralization of GM-CSF.

  2007cited by this paper
• The effect of telithromycin in acute exacerbations of asthma.

  2006cited by this paper
• Secondary Outcomes of a Pilot Randomized Trial of Azithromycin Treatment for Asthma

  2006cited by this paper
• Effect of clarithromycin on rhinovirus-16 infection in A549 cells

  2006cited by this paper
• Azithromycin reduces airway neutrophilia and interleukin-8 in patients with bronchiolitis obliterans syndrome.

  2006influential reference
• Macrolide resistance of Staphylococcus aureus and Haemophilus species associated with long-term azithromycin use in cystic fibrosis.

  2006cited by this paper
• Effects of claritromycin on inflammatory parameters and clinical conditions in children with bronchiectasis 1

  2006cited by this paper
• Cochrane Database of Systematic Reviews

  2006cited by this paper
• Meta-analysis of bacterial resistance to macrolides.

  2005cited by this paper
• The Disease-Modifying Effects of Twice-Weekly Oral Azithromycin in Patients with Bronchiectasis

  2005cited by this paper
• The effect of oral clarithromycin on health status and sputum bacteriology in stable COPD.

  2005cited by this paper
• Interleukin-1beta causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung.

  2005cited by this paper
• Oral erythromycin and the risk of sudden death.

  2005cited by this paper
• Azithromycin blocks neutrophil recruitment in Pseudomonas endobronchial infection.

  2004cited by this paper
• Molecular Mechanisms of Anti-Inflammatory Action of Erythromycin in Human Bronchial Epithelial Cells: Possible Role in the Signaling Pathway That Regulates Nuclear Factor- (cid:2) B Activation

  2004cited by this paper
• Regulatory effects of macrolides on bacterial virulence: potential role as quorum-sensing inhibitors.

  2004cited by this paper
• Macrolides and ketolides: azithromycin, clarithromycin, telithromycin.

  2004influential reference
• Clarithromycin reduces the severity of bronchial hyperresponsiveness in patients with asthma

  2004cited by this paper
• Effects of six-week clarithromycin therapy in corticosteroid-dependent asthma: A randomized, double-blind, placebo-controlled pilot study.

  2004cited by this paper
• Innate immune responses to LPS in mouse lung are suppressed and reversed by neutralization of GM-CSF via repression of TLR4

  2004cited by this paper
• Innate immune responses to LPS in mouse lung are suppressed and reversed by neutralization of GM-CSF via repression of TLR-4.

  2004cited by this paper
• Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase.

  2004cited by this paper
• Molecular Mechanisms of Anti-Inflammatory Action of Erythromycin in Human Bronchial Epithelial Cells: Possible Role in the Signaling Pathway That Regulates Nuclear Factor-κB Activation

  2004cited by this paper
• Maintenance azithromycin therapy for bronchiolitis obliterans syndrome: results of a pilot study.

  2003cited by this paper
• Alternative activation of macrophages

  2003cited by this paper
• Long-term efficacy and safety of clarithromycin treatment in patients with diffuse panbronchiolitis.

  2003cited by this paper
• In vivo and in vitro effects of macrolide antibiotics on mucus secretion in airway epithelial cells.

  2003cited by this paper
• Azithromycin in patients with cystic fibrosis chronically infected with Pseudomonas aeruginosa: a randomized controlled trial.

  2003cited by this paper
• Clarithromycin suppresses lipopolysaccharide-induced interleukin-8 production by human monocytes through AP-1 and NF-kappa B transcription factors.

  2002cited by this paper
• Effect of Azithromycin on the Severity of Bronchial Hyperresponsiveness in Patients with Mild Asthma

  2002cited by this paper
• Long term azithromycin in children with cystic fibrosis: a randomised, placebo-controlled crossover trial.

  2002cited by this paper
• Mycoplasma pneumoniae and Chlamydia pneumoniae in asthma: effect of clarithromycin.

  2002cited by this paper
• Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids

  2002cited by this paper
• Azithromycin modulates neutrophil function and circulating inflammatory mediators in healthy human subjects.

  2002cited by this paper
• Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages.

  2001cited by this paper
• Trial of roxithromycin in subjects with asthma and serological evidence of infection with Chlamydia pneumoniae.

  2001cited by this paper
• Clarithromycin potentiates glucocorticoid responsiveness in patients with asthma: results of a pilot study.

  2001cited by this paper
• Azithromycin-containing regimens for treatment of Mycobacterium avium complex lung disease.

  2001cited by this paper
• Interleukin-8 gene repression by clarithromycin is mediated by the activator protein-1 binding site in human bronchial epithelial cells.

  2000cited by this paper
• Long-term clarithromycin decreases prednisone requirements in elderly patients with prednisone-dependent asthma.

  2000cited by this paper
• Association between airway bacterial load and markers of airway inflammation in patients with stable chronic bronchitis.

  2000cited by this paper
• Anti‐inflammatory effect of roxithromycin in patients with aspirin‐intolerant asthma

  1999cited by this paper
• A pilot study of low-dose erythromycin in bronchiectasis.

  1999cited by this paper
• Improvement of survival in patients with diffuse panbronchiolitis treated with low-dose erythromycin.

  1998cited by this paper
• Therapeutic effect of erythromycin on influenza virus-induced lung injury in mice.

  1998cited by this paper
• Effect of clarithromycin on nasal mucus properties in healthy subjects and in patients with purulent rhinitis.

  1997cited by this paper
• Interleukin 1β,Tumor Necrosis Factor Alpha,and Interleukin 8 in Bronchoalveolar Lavage Fluid of Patients with Diffuse Panbronchiolitis: A Potential Mechanism of Macrolide Therapy

  1996cited by this paper
• Interleukin 1 beta, tumor necrosis factor alpha, and interleukin 8 in bronchoalveolar lavage fluid of patients with diffuse panbronchiolitis: a potential mechanism of macrolide therapy.

  1996cited by this paper
• Obliterative bronchiolitis after lung and heart-lung transplantation. An analysis of risk factors and management.

  1995cited by this paper
• Erythromycin inhibits neutrophil chemotaxis in bronchoalveoli of diffuse panbronchiolitis.

  1994cited by this paper
• Efficacy and safety of low-dose troleandomycin therapy in children with severe, steroid-requiring asthma.

  1993cited by this paper
• Benefits and complications of troleandomycin (TAO) in young children with steroid‐dependent asthma

  1991cited by this paper
• The use of macrolide antibiotic substances in the treatment of asthma.

  1970cited by this paper

• Understanding the rationale for metronidazole use in dogs and cats

  2025cites this paper
• Proteogenomic verifies targets underlying erythromycin alleviate neutrophil extracellular traps-induced inflammation

  2025influential citation
• The value of macrolides in the adjuvant treatment of pulmonary fibrosis: maybe a panacea

  2025cites this paper
• Diffuse panbronchiolitis as a rare complication of thymectomy and radiation therapy in a patient with thymoma: a case report

  2025cites this paper
• Azithromycin therapy in infants hospitalized for RSV bronchiolitis: airway MMP-9 levels and subsequent recurrent wheeze.

  2024cites this paper
• Use of Azithromycin in Pregnancy: More Doubts than Certainties

  2022cites this paper
• Asthma Management in Children.

  2022cites this paper
• Unprecedented Epimerization of an Azithromycin Analogue: Synthesis, Structure and Biological Activity of 2′-Dehydroxy-5″-Epi-Azithromycin

  2022cites this paper
• Azithromycin to Prevent Recurrent Wheeze Following Severe Respiratory Syncytial Virus Bronchiolitis.

  2022cites this paper
• Erythromycin attenuates oxidative stress-induced cellular senescence via the PI3K-mTOR signaling pathway in chronic obstructive pulmonary disease

  2022cites this paper
• Effects of intranasal azithromycin on features of cigarette smoke-induced lung inflammation.

  2021cites this paper
• Nonantimicrobial Actions of Macrolides: Overview and Perspectives for Future Development

  2021cites this paper
• The azithromycin to prevent wheezing following severe RSV bronchiolitis-II clinical trial: Rationale, study design, methods, and characteristics of study population

  2021cites this paper
• Overexpression of hypoxia-inducible factor 1α is associated with neutrophilic inflammation in chronic rhinosinusitis with nasal polyps.

  2020cites this paper
• Effectiveness and safety of medicines used in COPD patients

  2020cites this paper
• Effectiveness and safety of medicines used in COPD patients

  2020cites this paper
• Identification and treatment of T2-low asthma in the era of biologics

  2020cites this paper
• Azithromycin Treatment vs Placebo in Children With Respiratory Syncytial Virus–Induced Respiratory Failure

  2020cites this paper
• Pulmonary Anti-Inflammatory Effects of Macrolides

  2020cites this paper
• Azithromycin inhibits constitutive airway epithelial sodium channel activation in vitro and modulates downstream pathogenesis in vivo.

  2020cites this paper
• Pediatric respiratory diseases: A comprehensive textbook

  2020cites this paper
• A genome-wide analysis of targets of macrolide antibiotics in mammalian cells

  2020cites this paper
• Comparative efficacy of Chinese herbal injections combined with azithromycin for mycoplasma pneumonia in children: A Bayesian network meta‐analysis of randomized controlled trials

  2019cites this paper
• Appropriate lung management in patients with primary antibody deficiencies

  2019cites this paper
• Azithromycin does not improve disease severity in acute experimental pancreatitis

  2019cites this paper
• Primary immunodeficiency-related bronchiectasis in adults: comparison with bronchiectasis of other etiologies in a French reference center

  2019cites this paper
• Practical Considerations in Management of Non-eosinophilic Asthma

  2019cites this paper
• Management of Asthma in the Preschool Child.

  2019cites this paper
• Double-blind, placebo-controlled, randomized trial on low-dose azithromycin prophylaxis in patients with primary antibody deficiencies.

  2019cites this paper
• Effects of prophylactic antibiotics on patients with stable COPD: a systematic review and meta-analysis of randomized controlled trials

  2018cites this paper
• Challenges in the management of asthma associated with smoking-induced airway diseases

  2018cites this paper
• Macrolides in Children With Community-Acquired Pneumonia: Panacea or Placebo?

  2018cites this paper
• Towards precision medicine in severe asthma: Treatment algorithms based on treatable traits.

  2018cites this paper
• Current and future pharmacotherapy options for non-cystic fibrosis bronchiectasis

  2018cites this paper
• Severe asthma and macrolides

  2018cites this paper
• Risk factors for Haemophilus influenzae and pneumococcal respiratory tract colonization in CVID.

  2018cites this paper
• Microbes and the Role of Antibiotic Treatment for Wheezy Lower Respiratory Tract Illnesses in Preschool Children

  2017cites this paper
• New and developing non-adrenoreceptor small molecule drugs for the treatment of asthma

  2017cites this paper
• Solithromycin: A novel ketolide antibiotic

  2017cites this paper
• Acquired macrolide resistance genes in nontypeable Haemophilus influenzae

  2017cites this paper
• Immunomodulatory Effects of Tulathromycin in Rabbits

  2017cites this paper
• Steady-State Therapy with Azithromycin or Low-Dose Prednisolone in Paediatric Cystic Fibrosis Patients: Inflammatory Markers and Disease Progression

  2017cites this paper
• Effects of Macrolide Antibiotics on Th1 Cell and Th2 Cell Development Mediated by Langerhans Cells.

  2016cites this paper
• Inhibitory effect of Zanthoxylum bungeanum seed oil on ovalbumin‑induced lung inflammation in a murine model of asthma.

  2016cites this paper
• Addressing corticosteroid insensitivity in adults with asthma

  2016cites this paper
• Novel approaches to the management of noneosinophilic asthma

  2016cites this paper
• Effects of low-dose clarithromycin added to fluticasone on inflammatory markers and pulmonary function among children with asthma: A randomized clinical trial

  2016cites this paper
• Colonization of CF patients’ upper airways with S. aureus contributes more decisively to upper airway inflammation than P. aeruginosa

  2016cites this paper
• Clarithromycin prevents human respiratory syncytial virus-induced airway epithelial responses by modulating activation of interferon regulatory factor-3.

  2016cites this paper
• Long-term azithromycin ameliorates not only airway inflammation but also remodeling in a murine model of chronic asthma.

  2016cites this paper
• Allergic Bronchopulmonary Aspergillosis

  2016cites this paper
• Evaluation of a multidisciplinary adult integrated respiratory service in the UK.

  2016cites this paper
• Efficacy and safety of long‐term inhaled antibiotic for patients with noncystic fibrosis bronchiectasis: a meta‐analysis

  2016cites this paper
• Randomized trial to evaluate azithromycin's effects on serum and upper airway IL-8 levels and recurrent wheezing in infants with respiratory syncytial virus bronchiolitis.

  2015cites this paper
• Azithromycin for the Prevention of COPD Exacerbations: The Good, Bad, and Ugly.

  2015cites this paper
• Mechanisms of fluoroquinolone side effects 1 Non-antibiotic effects of fluoroquinolones in mammalian cells

  2015cites this paper
• Relationship between chronic rhinosinusitis and lower airway diseases: An extensive review

  2015cites this paper
• Non-anti-infective effects of antimicrobials and their clinical applications: a review.

  2015cites this paper
• Prophylactic Use of Macrolide Antibiotics for the Prevention of Chronic Obstructive Pulmonary Disease Exacerbation: A Meta-Analysis

  2015cites this paper
• Randomized trial to evaluate azithromycin’s effects on serum and upper airway IL-8 levels, and recurrent wheezing in infants with RSV bronchiolitis

  2015cites this paper
• Expression and Regulation of Transcription Factor FoxA2 in Chronic Rhinosinusitis With and Without Nasal Polyps

  2015cites this paper
• A Retrospective Longitudinal Within-Subject Risk Interval Analysis of Immunoglobulin Treatment for Recurrent Acute Exacerbation of Chronic Obstructive Pulmonary Disease

  2015cites this paper
• Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells

  2015cites this paper
• Sub-Inhibitory Antibiotics Enhance Virulence, Persistence, and Pathogenesis of Uropathogens

  2014cites this paper
• Azithromycin: mechanisms of action and their relevance for clinical applications.

  2014influential citation
• Prevalence and load of airway bacteria in chronic obstructive pulmonary disease

  2014cites this paper
• Long‐term macrolides for non‐cystic fibrosis bronchiectasis: A systematic review and meta‐analysis

  2014cites this paper
• Long-term, low-dose erythromycin monotherapy for Mycobacterium avium complex lung disease: a propensity score analysis.

  2014cites this paper
• Allergens, germs and asthma

  2014cites this paper
• The successful management of respiratory complications with long-term, low-dose macrolide administration in pediatric heart transplant recipients.

  2014cites this paper
• Comparative Effectiveness of Ceftriaxone in Combination With a Macrolide Compared With Ceftriaxone Alone for Pediatric Patients Hospitalized With Community-acquired Pneumonia

  2014cites this paper
• Bronchiolitis in a patient with ulcerative colitis treated with erythromycin.

  2014cites this paper
• Endotype Driven Treatment of Asthma

  2014cites this paper
• Fungal allergy in asthma–state of the art and research needs

  2014cites this paper
• Respiratory failure in a term newborn due to compound heterozygous ABCA3 mutation: the case report of another lethal variant

  2014cites this paper
• Macrolides à faible dose dans les pathologies pulmonaires

  2013cites this paper
• The Pharmacological Approach to the Elderly COPD Patient

  2013cites this paper
• Randomised controlled trial of azithromycin in smokers with asthma

  2013cites this paper
• Developments in the field of allergy in 2012 through the eyes of Clinical & Experimental Allergy

  2013cites this paper
• Microbes and mucosal immune responses in asthma.

  2013cites this paper
• L’asthme sévère réfractaire : quels traitements disponibles et à venir ?

  2013cites this paper
• Risks of population antimicrobial resistance associated with chronic macrolide use for inflammatory airway diseases.

  2013cites this paper
• Antibiotic prophylaxis in primary immune deficiency disorders.

  2013cites this paper
• Liposomal clarithromycin delivery for the treatment of pseudomonal lung infection in cystic fibrosis.

  2013cites this paper
• Becker Digital

  year unknowncites this paper
• Comparative effectiveness of ceftriaxone in combination with a macrolide relative to ceftriaxone alone for pediatric patients hospitalized with community acquired pneumonia

  year unknowncites this paper