Estradiol-Induced Regression in T47D:A18/PKCα Tumors Requires the Estrogen Receptor and Interaction with the Extracellular Matrix

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Molecular Cancer Research

• Publication date

  2009-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/1541-7786.MCR-08-0415PMID 19372579PMCID PMC2743931
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Unraveling the microenvironmental influences on the normal mammary gland and breast cancer.

  2008cited by this paper
• Membrane ERalpha-dependent activation of PKCalpha in endometrial cancer cells by estradiol.

  2008cited by this paper
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  2008cited by this paper
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• Protein Kinase C α is a marker for antiestrogen resistance and is involved in the growth of tamoxifen resistant human breast cancer cells

  2007cited by this paper
• Protein Kinase C alpha is a marker for antiestrogen resistance and is involved in the growth of tamoxifen resistant human breast cancer cells.

  2007cited by this paper
• Fulvestrant (ICI 182,780)-dependent Interacting Proteins Mediate Immobilization and Degradation of Estrogen Receptor-α*

  2006cited by this paper
• Upregulation of PKC-delta contributes to antiestrogen resistance in mammary tumor cells.

  2005cited by this paper
• Reduced PTEN expression predicts relapse in patients with breast carcinoma treated by tamoxifen

  2005cited by this paper
• Integration of the extranuclear and nuclear actions of estrogen.

  2005cited by this paper
• Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells.

  2005cited by this paper
• Upregulation of PKC-δ contributes to antiestrogen resistance in mammary tumor cells

  2005cited by this paper
• Reversal of tamoxifen resistant breast cancer by low dose estrogen therapy.

  2005cited by this paper
• Overexpression of PKCalpha is required to impart estradiol inhibition and tamoxifen-resistance in a T47D human breast cancer tumor model.

  2005cited by this paper
• Estrogen-induced apoptosis in a breast cancer model resistant to long-term estrogen withdrawal.

  2005cited by this paper
• Measurement of steroid hormone receptors in breast cancer patients on tamoxifen

  2004cited by this paper
• PC Cell-Derived Growth Factor Mediates Tamoxifen Resistance and Promotes Tumor Growth of Human Breast Cancer Cells

  2004cited by this paper
• Apoptotic action of estrogen

  2004cited by this paper
• HER-2 Amplification, HER-1 Expression, and Tamoxifen Response in Estrogen Receptor-Positive Metastatic Breast Cancer

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• Mechanisms of tamoxifen resistance.

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• Protein kinase C: a target for anticancer drugs?

  2004cited by this paper
• ACTR/AIB1 Functions as an E2F1 Coactivator To Promote Breast Cancer Cell Proliferation and Antiestrogen Resistance

  2004cited by this paper
• Increased Constitutive Activity of PKB/Akt in Tamoxifen Resistant Breast Cancer MCF-7 Cells

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  2004cited by this paper
• Sequencing of Endocrine Therapy in Postmenopausal Women with Advanced Breast Cancer

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  2004cited by this paper
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  2004cited by this paper
• Expression analysis of estrogen receptor alpha coregulators in breast carcinoma: evidence that NCOR1 expression is predictive of the response to tamoxifen.

  2003cited by this paper
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  2003cited by this paper
• Protein kinase C: a target for anticancer drugs?

  2003cited by this paper
• Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure

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• Live and let die: regulatory mechanisms in Fas-mediated apoptosis.

  2003cited by this paper
• Changing role of the oestrogen receptor in the life and death of breast cancer cells.

  2003cited by this paper
• Direct Binding of Syndecan-4 Cytoplasmic Domain to the Catalytic Domain of Protein Kinase Cα (PKCα) Increases Focal Adhesion Localization of PKCα*

  2003cited by this paper
• Apoptotic action of 17beta-estradiol in raloxifene-resistant MCF-7 cells in vitro and in vivo.

  2003cited by this paper
• Apoptotic Action of 17β-Estradiol in Raloxifene-Resistant MCF-7 Cells In Vitro and In Vivo

  2003cited by this paper
• Expression of constitutively active Akt-3 in MCF-7 breast cancer cells reverses the estrogen and tamoxifen responsivity of these cells in vivo.

  2003cited by this paper
• Cyclic, proteasome-mediated turnover of unliganded and liganded ERalpha on responsive promoters is an integral feature of estrogen signaling.

  2003cited by this paper
• Direct binding of syndecan-4 cytoplasmic domain to the catalytic domain of protein kinase C alpha (PKC alpha) increases focal adhesion localization of PKC alpha.

  2003cited by this paper
• Growth factor receptor cross-talk with estrogen receptor as a mechanism for tamoxifen resistance in breast cancer.

  2003cited by this paper
• Antisense therapy directed to protein kinase C-alpha (Affinitak, LY900003/ISIS 3521): potential role in breast cancer.

  2003cited by this paper
• Normal breast epithelial cells induce apoptosis of breast cancer cells via Fas signaling.

  2002cited by this paper
• Estrogen as therapy for breast cancer

  2002cited by this paper
• Site-Directed Perturbation of Protein Kinase C- Integrin Interaction Blocks Carcinoma Cell Chemotaxis

  2002cited by this paper
• Fulvestrant ('Faslodex')--a new treatment option for patients progressing on prior endocrine therapy.

  2002cited by this paper
• Overexpression of HER-2 as a resistance mechanism to hormonal therapy for breast cancer.

  2001cited by this paper
• Protein kinase C alpha expression is inversely related to ER status in endometrial carcinoma: possible role in AP-1-mediated proliferation of ER-negative endometrial cancer.

  2001cited by this paper
• Phosphorylation of ERK1/2 mitogen‐activated protein kinase is associated with poor response to anti‐hormonal therapy and decreased patient survival in clinical breast cancer

  2001cited by this paper
• The Human Estrogen Receptor-α Is a Ubiquitinated Protein Whose Stability Is Affected Differentially by Agonists, Antagonists, and Selective Estrogen Receptor Modulators*

  2001cited by this paper
• Effect of Long-Term Estrogen Deprivation on Apoptotic Responses of Breast Cancer Cells to 17β-Estradiol

  2001influential reference
• Integrin alpha 5 beta 1 suppresses apoptosis triggered by serum starvation but not phorbol ester in MCF-7 breast cancer cells that overexpress protein kinase C-alpha.

  2001cited by this paper
• Integrin-protein kinase C relationships.

  2001cited by this paper
• Effect of long-term estrogen deprivation on apoptotic responses of breast cancer cells to 17beta-estradiol.

  2001cited by this paper
• Novel antitumor effect of estradiol in athymic mice injected with a T47D breast cancer cell line overexpressing protein kinase Calpha.

  2001cited by this paper
• High-dose estrogen treatment in postmenopausal breast cancer patients heavily exposed to endocrine therapy

  2001cited by this paper
• Estrogen receptor pathways to AP-1.

  2000cited by this paper
• Protein kinase C isozymes and the regulation of diverse cell responses.

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• Ligand-, Cell-, and Estrogen Receptor Subtype (α/β)-dependent Activation at GC-rich (Sp1) Promoter Elements*

  2000cited by this paper
• Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements.

  2000cited by this paper
• Steroid‐induced androgen receptor–oestradiol receptor β–Src complex triggers prostate cancer cell proliferation

  2000cited by this paper
• Estrogen Receptor α Rapidly Activates the IGF-1 Receptor Pathway*

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• Estradiol hypersensitivity and mitogen-activated protein kinase expression in long-term estrogen deprived human breast cancer cells in vivo.

  2000cited by this paper
• Antitumor action of physiological estradiol on tamoxifen-stimulated breast tumors grown in athymic mice.

  2000cited by this paper
• Stable transfection of protein kinase C alpha cDNA in hormone-dependent breast cancer cell lines

  2000cited by this paper
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  2000cited by this paper
• Increased activator protein-1 DNA binding and c-Jun NH2-terminal kinase activity in human breast tumors with acquired tamoxifen resistance.

  1999cited by this paper
• Overexpression of protein kinase C-alpha in MCF-7 breast cancer cells results in differential regulation and expression of alphavbeta3 and alphavbeta5.

  1999cited by this paper
• Distinct effects on the conformation of estrogen receptor alpha and beta by both the antiestrogens ICI 164,384 and ICI 182,780 leading to opposite effects on receptor stability.

  1999cited by this paper
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  1999cited by this paper
• Re: Effects of the antiestrogens tamoxifen, toremifene, and ICI 182,780 on endometrial cancer growth.

  1999cited by this paper
• Randomized trial of diethylstilbestrol vs. tamoxifen in postmenopausal women with metastatic breast cancer. An updated analysis

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  1998cited by this paper
• Elevated mitogen-activated protein kinase activity in estrogen-nonresponsive human breast cancer cells.

  1998cited by this paper
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  1998cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
• MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype.

  1995cited by this paper
• Increasing the number of tandem estrogen response elements increases the estrogenic activity of a tamoxifen analogue.

  1995cited by this paper
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  1994cited by this paper
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  1994cited by this paper
• The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling.

  1993cited by this paper
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  1987cited by this paper
• Dynamics of estrogen receptor turnover in uterine cells in vitro and in uteri in vivo.

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• Characterization of the estrogen receptor and its dynamics in MCF-7 human breast cancer cells using a covalently attaching antiestrogen.

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• ERα upregulates the expression of long non-coding RNA LINC00472 which suppresses the phosphorylation of NF-κB in breast cancer

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• Activation of membrane-associated estrogen receptors decreases food and water intake in ovariectomized rats.

  2013cites this paper
• Retraction Note to: Extranuclear ERα is associated with regression of T47D PKCα-overexpressing, tamoxifen-resistant breast cancer

  2013cites this paper
• Extranuclear ERα is associated with regression of T47D PKCα-overexpressing, tamoxifen-resistant breast cancer

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