RGS4 inhibits G-protein signaling in cardiomyocytes.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Circulation

• Publication date

  1999-01-26

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/01.CIR.99.3.441PMID 9918533
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1998cited by this paper
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• Subcellular localization of G‐proteins in primary‐cultured mouse preadipocytes and adipocytes

  1997cited by this paper
• The cellular and molecular response of cardiac myocytes to mechanical stress.

  1997influential reference
• Interleukin-1β Is a Negative Transcriptional Regulator of α1-Adrenergic Induced Gene Expression in Cultured Cardiac Myocytes*

  1996cited by this paper
• Interleukin-1beta is a negative transcriptional regulator of alpha1-adrenergic induced gene expression in cultured cardiac myocytes.

  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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• Identification of a Domain in the Angiotensin II Type 1 Receptor Determining Gq Coupling by the Use of Receptor Chimeras (*)

  1995cited by this paper
• Blockade of the renin-angiotensin system in cardiac pressure-overload hypertrophy in rats.

  1995cited by this paper
• Ventricular Expression of a MLC-2v-ras Fusion Gene Induces Cardiac Hypertrophy and Selective Diastolic Dysfunction in Transgenic Mice (*)

  1995cited by this paper
• Signaling Pathways for Cardiac Growth and Hypertrophy

  1995influential reference
• Signalling from TPA to MAP kinase requires protein kinase C, raf and MEK: reconstitution of the signalling pathway in vitro.

  1994cited by this paper
• Mitogen-activated protein kinases mediate changes in gene expression, but not cytoskeletal organization associated with cardiac muscle cell hypertrophy

  1994cited by this paper
• Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype.

  1993cited by this paper
• Functional coupling between endothelin receptors and multiple G-proteins in rat heart myocytes.

  1993cited by this paper
• Hypertension, left ventricular hypertrophy, ventricular ectopy, and sudden death.

  1993cited by this paper
• Metabolically-modulated growth and phenotype of the rat heart.

  1992cited by this paper
• Hypertension, left ventricular hypertrophy, ventricular ectopy, and sudden death.

  1992cited by this paper
• Co-regulation of the atrial natriuretic factor and cardiac myosin light chain-2 genes during alpha-adrenergic stimulation of neonatal rat ventricular cells. Identification of cis sequences within an embryonic and a constitutive contractile protein gene which mediate inducible expression.

  1991cited by this paper
• Hypertrophy, fibrosis and diastolic dysfunction in early canine experimental hypertension.

  1991cited by this paper
• Peptide growth factors can provoke "fetal" contractile protein gene expression in rat cardiac myocytes.

  1990cited by this paper
• Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy.

  1990cited by this paper
• Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study.

  1990cited by this paper
• Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study.

  1990cited by this paper
• Alpha 1-adrenergic stimulation of cardiac gene transcription in neonatal rat myocardial cells. Effects on myosin light chain-2 gene expression.

  1988cited by this paper
• Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload.

  1988cited by this paper
• Acquisition by innervated cardiac myocytes of a pertussis toxin-specific regulatory protein linked to the alpha 1-receptor.

  1985cited by this paper
• Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response.

  1983cited by this paper
• Myocyte Hypertrophy in Neonatal Rat Heart Cultures and Its Regulation by Serum and by Catecholamines

  1982cited by this paper

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  2000cites this paper
• Heterotrimeric G proteins in heart disease.

  2000cites this paper
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