Nemo-Like Kinase Associated with Proliferation and Apoptosis by c-Myb Degradation in Breast Cancer

Nemo-like kinase (NLK), a mediator of the Wnt signaling pathway, binds directly to c-Myb, leading to its phosphorylation, ubiquitination and proteasome-dependent degradation. NLK was significantly downregulated in the breast cancer tissues compared to corresponding normal tissues. NLK expression was negatively correlated with c-Myb expression. NLK suppressed proliferation, induced apoptosis and mediated c-Myb degradation in MCF-7 cells via a mechanism that seems to involve c-myc and Bcl2. These findings might provide a novel target for therapeutic intervention in patients with breast cancer.

• Publication year

  2013

• Venue

  PLoS ONE

• Publication date

  2013-07-23

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1371/journal.pone.0069148PMID 23935942PMCID 3720543
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• An update on the genomic landscape of breast cancer: new opportunity for personalized therapy?

  2012cited by this paper
• Breast cancer manifested by hematologic disorders.

  2012influential reference
• Clinical and biological significance of nemo-like kinase expression in glioma.

  2011cited by this paper
• Potential Tumor Suppressor Role for the c-Myb Oncogene in Luminal Breast Cancer

  2010cited by this paper
• MYB suppresses differentiation and apoptosis of human breast cancer cells

  2010cited by this paper
• Regulation of FOXO1 by TAK1-Nemo-like Kinase Pathway*

  2010cited by this paper
• Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck

  2009cited by this paper
• Role of c-Myb during prolactin-induced signal transducer and activator of transcription 5a signaling in breast cancer cells.

  2009cited by this paper
• Nemo-Like Kinase, an Essential Effector of Anterior Formation, Functions Downstream of p38 Mitogen-Activated Protein Kinase

  2009cited by this paper
• Nemo‐like kinase induces apoptosis and inhibits androgen receptor signaling in prostate cancer cells

  2009cited by this paper
• Fbxw7 Acts as an E3 Ubiquitin Ligase That Targets c-Myb for Nemo-like Kinase (NLK)-induced Degradation*

  2008cited by this paper
• Wnt pathway and breast cancer.

  2007cited by this paper
• The Wnt-NLK signaling pathway inhibits A-Myb activity by inhibiting the association with coactivator CBP and methylating histone H3.

  2005cited by this paper
• Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK.

  2004influential reference
• Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/β-catenin synergy

  2003cited by this paper
• Nemo-like kinase induces apoptosis in DLD-1 human colon cancer cells.

  2003cited by this paper
• c-Myc Is Essential but Not Sufficient for c-Myb-mediated Block of Granulocytic Differentiation*

  2003cited by this paper
• Wnt1 and Wnt5a induce cyclin D1 expression through ErbB1 transactivation in HC11 mammary epithelial cells (EMBO reports, February 2003) (Correction)

  2003cited by this paper
• Tamoxifen functions as a molecular agonist inducing cell cycle-associated genes in breast cancer cells.

  2003cited by this paper
• Drosophila nemo is an essential gene involved in the regulation of programmed cell death.

  2002cited by this paper
• The tissue polarity gene nemo carries out multiple roles in patterning during Drosophila development.

  2001cited by this paper
• c-Myb and Bcl-x overexpression predicts poor prognosis in colorectal cancer: clinical and experimental findings.

  2001cited by this paper
• MYB oncogene amplification in hereditary BRCA1 breast cancer.

  2000cited by this paper
• c-Myb is critical for murine colon development

  1999cited by this paper
• Nlk is a murine protein kinase related to Erk/MAP kinases and localized in the nucleus.

  1998cited by this paper
• Mechanisms of Wnt signaling in development.

  1998cited by this paper
• Myb proteins in life, death and differentiation.

  1998cited by this paper
• Binary specification of the embryonic lineage in Caenorhabditis elegans

  1997cited by this paper
• Microsatellite deletions in the c-myb transcriptional attenuator region associated with over-expression in colon tumour cell lines

  1997cited by this paper
• Resistance to apoptosis in CTLL-2 cells constitutively expressing c-Myb is associated with induction of BCL-2 expression and Myb-dependent regulation of bcl-2 promoter activity.

  1997cited by this paper
• v-Myb of E26 leukemia virus up-regulates bcl-2 and suppresses apoptosis in myeloid cells.

  1996cited by this paper
• P-glycoprotein-mediated acquired multidrug resistance of human lung cancer cells in vivo.

  1996cited by this paper
• Effects of antisense c-myb oligonucleotides on vascular smooth muscle cell proliferation and response to vessel wall injury.

  1995cited by this paper
• Myb expression is higher in malignant human colonic carcinoma and premalignant adenomatous polyps than in normal mucosa.

  1992cited by this paper
• Myb: a transcriptional activator linking proliferation and differentiation in hematopoietic cells.

  1992cited by this paper
• Inhibition of proliferation by c-myb antisense oligodeoxynucleotides in colon adenocarcinoma cell lines that express c-myb.

  1991cited by this paper
• G1/S transition in normal human T-lymphocytes requires the nuclear protein encoded by c-myb.

  1989cited by this paper
• An oligomer complementary to c-myb-encoded mRNA inhibits proliferation of human myeloid leukemia cell lines.

  1989cited by this paper
• A c-myb antisense oligodeoxynucleotide inhibits normal human hematopoiesis in vitro.

  1988cited by this paper

• Activation of nemo-like kinase in diamond blackfan anemia suppresses early erythropoiesis by preventing mitochondrial biogenesis

  2024cites this paper
• Atypical MAPKs in cancer

  2024cites this paper
• MSI2 regulates NLK-mediated EMT and PI3K/AKT/mTOR pathway to promote pancreatic cancer progression

  2024cites this paper
• The expression of NLK is functionally associated with colorectal cancers (CRC)

  2021cites this paper
• Therapeutic Targeting of Nemo-like Kinase in Primary and Acquired Endocrine-resistant Breast Cancer

  2021cites this paper
• NLK interacts with 14-3-3ζ to restore the expression of E-cadherin

  2020cites this paper
• Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase

  2020cites this paper
• Decreased expression of nemo-like kinase in melanoma is correlated with increased vascularity and metastasis.

  2019cites this paper
• New insights into the roles of the FOXO3 and P27Kip1 genes in signaling pathways

  2019cites this paper
• Overexpression of Nemo-like kinase promotes the proliferation and invasion of lung cancer cells and indicates poor prognosis.

  2019cites this paper
• Expression of Nemo-like kinase in cervical squamous cell carcinoma: a clinicopathological study

  2018cites this paper
• Nanog suppresses the expression of vasa by directly regulating nlk1 in the early zebrafish embryo.

  2017cites this paper
• NLK-mediated phosphorylation of HDAC1 negatively regulates Wnt signaling

  2017cites this paper
• Identification des composantes du système ubiquitine-protéasome régulant la stabilité de la MAPK atypique ERK3

  2017influential citation
• ON 01910.Na inhibits growth of diffuse large B-cell lymphoma by cytoplasmic sequestration of sumoylated C-MYB/TRAF6 complex.

  2016cites this paper
• Nemo-like kinase as a negative regulator of nuclear receptor Nurr1 gene transcription in prostate cancer

  2016cites this paper
• Protein Modifications in Pathogenic Dysregulation of Signaling

  2015cites this paper
• Expression of Nemo-like kinase was increased and negatively correlated with the expression of TCF4 in lung cancers.

  2015cites this paper
• Cyclin C interacts with steroid receptor coactivator 2 and upregulates cell cycle genes in MCF-7 cells.

  2015cites this paper
• The emerging role of Nemo-like kinase (NLK) in the regulation of cancers

  2015cites this paper
• Functional characterization of the interaction of Paraxial protocadherin (PAPC) and Nemo like kinase1 (Nlk1) during Xenopus gastrulation

  2015cites this paper
• In vivo RNAi screen identifies NLK as a negative regulator of mesenchymal activity in glioblastoma

  2015cites this paper
• Prognostic significance of Nemo-like kinase expression in patients with hepatocellular carcinoma

  2015cites this paper
• Post-translational Modification of Tcf/Lef: New Insights into the Regulation of Wnt/β-Catenin Signaling

  2015cites this paper
• NLK, a novel target of miR-199a-3p, functions as a tumor suppressor in colorectal cancer.

  2014cites this paper