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Altered metabolic patterns induced in the normal rat by feeding an adequate diet containing fructose as sole carbohydrate.

R. Hill,N. Baker,I. Chaikoff

Published 1954 in Journal of Biological Chemistry

ABSTRACT

The response of the blood sugar level in the early intervals after the administration of glucose (glucose tolerawe t,est) is generally considered to be an indication of the animal’s capacit(y to utilize glucose (1). As judged by this test, it has been established that, after fasting (2, 3) or the feeding of a diet deficient in rarbohydrat,e (4, 5), the animal loses its tolerance for glucose. Apparently frequent ingestions of adequate amounts of carbohydrate are required to keep active the animal’s mechanisms for disposal of glucose. The specificity of glucose in this respect has not hit.herto been realized, and this phenomenon is brought out in the present study. It is shown here that, when large amounts of fructose are fed to normal rats as the sole carbohydrate in an adequate synthetic diet, a loss in capacity to utilize glurose ensues, a loss apparently similar to that observed in the fast,ed rat. In order to investigate the mechanism responsible for this phenomenon, we further studied the utilization of C14-labeled glucose, fructose, and acetate by various tissues of normal rats previously fed either a glucose-containing or a fructose-containing diet. Only in liver was an altered metabolic pattern observed in response to fructose feeding, and this finding is discussed from the standpoint of an enzymatic adaptation to diet.

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