Evidence for the involvement of the Ss protein of the mouse in the hemolytic complement system

A significant within-strain correlation has been demonstrated between the levels of Ss and hemolytic complement (C) activity in two Ss-high strains. Mouse serum specifically depleted of Ss by absorption with F(ab')2 fragments of anti-Ss had negligible C activity. In control experiments, Ss-specific antigen-antibody complexes formed with F(ab')2 fragments did not fix rabbit C, and bovine serum albumin-specific antigen-antibody complexes formed with F(ab')2 fragments did not fix mouse C. Therefore the removal of C activity by anti-Ss [F(ab')2] was apparently not due to C fixation. These results suggest that the Ss protein is a necessary component of the C system.

• Publication year

  1975

• Venue

  Journal of Experimental Medicine

• Publication date

  1975-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/JEM.141.5.1216PMID 805206PMCID 2189786
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genetic studies of the H-2-associated complement gene.

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  1973influential reference
• Two complement interaction sites in guinea pig immunoglobulins.

  1971cited by this paper
• DIFFERENCES IN SERUM COMPLEMENT ACTIVITY AMONG INBRED STRAINS OF MICE.

  1964cited by this paper
• Activity of mouse complement.

  1962cited by this paper

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  2012cites this paper
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  2007cites this paper
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  2005cites this paper
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  2005cites this paper
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  2005cites this paper
• Genetics of the complement system.

  2000cites this paper
• Genetic regulation of testosterone-induced immune suppression.

  1987cites this paper
• Molecular genetics of the fourth component of human complement.

  1987cites this paper
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  1983cites this paper
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  1983cites this paper
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  1981cites this paper
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  1980cites this paper
• A murine C4 molecule with reduced hemolytic efficiency

  1980cites this paper
• Le complexe d'histocompatibilité majeur chez l'homme et chez les animaux

  1979cites this paper
• Studies on murine Ss protein: demonstration that S region encodes structural gene for fourth component of complement.

  1979cites this paper
• Evaluation of the role of C4 in the cellular immune response in vitro.

  1979cites this paper
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  1978cites this paper
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  1978cites this paper
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  1978cites this paper
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  1978cites this paper
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  1977cites this paper
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• Component fragments obtained by acid dissociation of the alpha- glycoprotein associated with beta2-microglobulin in mouse plasma.

  1977cites this paper
• The Major Histocompatibility System of the Mouse

  1977cites this paper
• Contemporary Topics in Immunobiology

  1977cites this paper
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  1977cites this paper
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  1976cites this paper
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  1976cites this paper
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  1976cites this paper
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  1976cites this paper
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  1976cites this paper
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