Pulmonary surfactant proteins A and D: innate immune functions and biomarkers for lung diseases.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Current pharmaceutical design

• Publication date

  2006-01-31

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2174/138161206775474387PMID 16472150
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Immunomodulatory effects of macrolides in the lung: lessons from in-vitro and in-vivo models.

  2004cited by this paper
• Pulmonary Collectins Enhance Phagocytosis of Mycobacterium avium through Increased Activity of Mannose Receptor1

  2004cited by this paper
• Pulmonary Surfactant Protein A Augments the Phagocytosis of Streptococcus pneumoniae by Alveolar Macrophages through a Casein Kinase 2-dependent Increase of Cell Surface Localization of Scavenger Receptor A*

  2004cited by this paper
• Surfactant proteins A and D inhibit the growth of Gram-negative bacteria by increasing membrane permeability.

  2003cited by this paper
• Macrophage-independent Fungicidal Action of the Pulmonary Collectins*

  2003cited by this paper
• The pulmonary renin-angiotensin system.

  2003cited by this paper
• By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation.

  2003cited by this paper
• Lactoferrin and surfactant protein A exhibit distinct binding specificity to F protein and differently modulate respiratory syncytial virus infection

  2003cited by this paper
• Direct binding of Toll-like receptor 2 to zymosan, and zymosan-induced NF-kappa B activation and TNF-alpha secretion are down-regulated by lung collectin surfactant protein A.

  2003cited by this paper
• Re-evaluation of fibrogenic cytokines in lung fibrosis.

  2003cited by this paper
• Human Surfactant Protein D (SP-D) Binds Mycoplasma pneumoniae by High Affinity Interactions with Lipids*

  2002cited by this paper
• Role of Surfactant Proteins A, D, and C1q in the Clearance of Apoptotic Cells In Vivo and In Vitro: Calreticulin and CD91 as a Common Collectin Receptor Complex1

  2002cited by this paper
• Pulmonary Surfactant Protein A Up-Regulates Activity of the Mannose Receptor, a Pattern Recognition Receptor Expressed on Human Macrophages1

  2002cited by this paper
• Serum surfactant proteins‐A and ‐D as biomarkers in idiopathic pulmonary fibrosis

  2002cited by this paper
• Surfactant Protein D Enhances Clearance of Influenza A Virus from the Lung In Vivo1

  2001cited by this paper
• Surfactant Protein A Enhances Alveolar Macrophage Phagocytosis of Apoptotic Neutrophils1

  2001cited by this paper
• Clinical significance of surfactant protein D as a serum marker for evaluating pulmonary fibrosis in patients with systemic sclerosis.

  2001cited by this paper
• Immunosuppressed surfactant protein A-deficient mice have increased susceptibility to Pneumocystis carinii infection.

  2001cited by this paper
• Surfactant Protein A Inhibits Peptidoglycan-induced Tumor Necrosis Factor-α Secretion in U937 Cells and Alveolar Macrophages by Direct Interaction with Toll-like Receptor 2*

  2001cited by this paper
• Rat Mannose-Binding Protein A Binds CD14

  2001cited by this paper
• Diagnostic significance of surfactant proteins A and D in sera from patients with radiation pneumonitis.

  2001cited by this paper
• Lipopolysaccharide Is in Close Proximity to Each of the Proteins in Its Membrane Receptor Complex

  2001cited by this paper
• Clinical significance of serum pulmonary surfactant proteins a and d for the early detection of radiation pneumonitis.

  2001cited by this paper
• The roles of surfactant proteins A and D in innate immunity

  2000cited by this paper
• Serum surfactant proteins A and D as prognostic factors in idiopathic pulmonary fibrosis and their relationship to disease extent.

  2000cited by this paper
• Lipoglycans Are Putative Ligands for the Human Pulmonary Surfactant Protein A Attachment to Mycobacteria

  2000cited by this paper
• Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice.

  2000cited by this paper
• Serum levels of surfactant proteins A and D are useful biomarkers for interstitial lung disease in patients with progressive systemic sclerosis.

  2000cited by this paper
• Surfactant Proteins A and D Bind CD14 by Different Mechanisms*

  2000cited by this paper
• Distinct Effects of Surfactant Protein A or D Deficiency During Bacterial Infection on the Lung1

  2000cited by this paper
• Surfactant-associated protein A inhibits LPS-induced cytokine and nitric oxide production in vivo.

  2000cited by this paper
• Toll-like receptors in the induction of the innate immune response

  2000cited by this paper
• Serial changes in surfactant-associated proteins in lung and serum before and after onset of ARDS.

  1999cited by this paper
• The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens

  1999cited by this paper
• MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4

  1999cited by this paper
• Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.

  1999cited by this paper
• Surfactant protein D binds to Mycobacterium tuberculosis bacilli and lipoarabinomannan via carbohydrate-lectin interactions resulting in reduced phagocytosis of the bacteria by macrophages.

  1999cited by this paper
• Mechanisms of phagocytosis in macrophages.

  1999cited by this paper
• Pulmonary surfactant protein A modulates the cellular response to smooth and rough lipopolysaccharides by interaction with CD14.

  1999cited by this paper
• Introduction of mannose binding protein-type phosphatidylinositol recognition into pulmonary surfactant protein A.

  1999cited by this paper
• Collectins and pulmonary host defense.

  1998cited by this paper
• Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D.

  1998cited by this paper
• Surfactant Protein-D Regulates Surfactant Phospholipid Homeostasis in Vivo *

  1998cited by this paper
• Surfactant protein-A-deficient mice are susceptible to Pseudomonas aeruginosa infection.

  1998cited by this paper
• SP-A enhances uptake of bacillus Calmette-Guérin by macrophages through a specific SP-A receptor.

  1997cited by this paper
• Enzyme-linked immunosorbent assay using F(ab')2 fragment for the detection of human pulmonary surfactant protein D in sera.

  1997cited by this paper
• SP-A enhances phagocytosis of Klebsiella by interaction with capsular polysaccharides and alveolar macrophages.

  1997cited by this paper
• Surfactant protein A-deficient mice are susceptible to group B streptococcal infection.

  1997cited by this paper
• Effects of cigarette smoking on the serum concentration of lung surfactant protein A (SP-A).

  1997cited by this paper
• Pulmonary surfactant protein D in sera and bronchoalveolar lavage fluids.

  1995cited by this paper
• Surfactant protein a promotes attachment of Mycobacterium tuberculosis to alveolar macrophages during infection with human immunodeficiency virus.

  1995cited by this paper
• Surfactant protein A predicts survival in idiopathic pulmonary fibrosis.

  1995cited by this paper
• Pulmonary surfactant protein A: a serum marker of pulmonary fibrosis in patients with collagen vascular diseases.

  1995cited by this paper
• Aberrant appearance of lung surfactant protein A in sera of patients with idiopathic pulmonary fibrosis and its clinical significance.

  1995cited by this paper
• Pulmonary surfactant protein A mediates enhanced phagocytosis of Mycobacterium tuberculosis by a direct interaction with human macrophages.

  1995cited by this paper
• Enzyme-linked immunosorbent assay for human pulmonary surfactant protein D.

  1994cited by this paper
• Pulmonary surfactant proteins.

  1994cited by this paper
• The C-type carbohydrate recognition domain (CRD) superfamily.

  1994cited by this paper
• Aggregation and opsonization of type A but not type B Hemophilus influenzae by surfactant protein A.

  1994cited by this paper
• Brief report: deficiency of pulmonary surfactant protein B in congenital alveolar proteinosis.

  1993cited by this paper
• Surfactant protein-A concentration in bronchoalveolar lavage fluids of patients with pulmonary alveolar proteinosis.

  1993cited by this paper
• Elevated levels of lung surfactant protein A in sera from patients with idiopathic pulmonary fibrosis and pulmonary alveolar proteinosis.

  1993cited by this paper
• Interactions of surfactant protein D with bacterial lipopolysaccharides. Surfactant protein D is an Escherichia coli-binding protein in bronchoalveolar lavage.

  1992cited by this paper
• 120-kD surface glycoprotein of Pneumocystis carinii is a ligand for surfactant protein A.

  1992cited by this paper
• Pulmonary surfactant protein D specifically binds to phosphatidylinositol.

  1992cited by this paper
• The major glycolipid recognized by SP-D in surfactant is phosphatidylinositol.

  1992cited by this paper
• Binding specificity of lung surfactant protein SP-D for glucosylceramide.

  1992cited by this paper
• Pulmonary surfactant protein a in pleural effusions

  1992cited by this paper
• Binding of pulmonary surfactant protein A to galactosylceramide and asialo-GM2.

  1992cited by this paper
• Specificity of lung surfactant protein SP-A for both the carbohydrate and the lipid moieties of certain neutral glycolipids.

  1992cited by this paper
• Surfactant chemical composition and biophysical activity in acute respiratory distress syndrome.

  1991cited by this paper
• Surfactant protein A is opsonin in phagocytosis of herpes simplex virus type 1 by rat alveolar macrophages.

  1991cited by this paper
• Pulmonary surfactant protein A (SP-A) specifically binds dipalmitoylphosphatidylcholine.

  1991cited by this paper
• Idiopathic pulmonary fibrosis. Abnormalities in the bronchoalveolar lavage content of surfactant protein A.

  1991cited by this paper
• Changes in surfactant in bronchoalveolar lavage fluid after hemithorax irradiation in patients with mesothelioma.

  1990cited by this paper
• Pulmonary surfactant protein A enhances the host-defense mechanism of rat alveolar macrophages.

  1990cited by this paper
• Surfactant protein D is a divalent cation-dependent carbohydrate-binding protein.

  1990cited by this paper
• Human pulmonary surfactant protein (SP-A), a protein structurally homologous to C1q, can enhance FcR- and CR1-mediated phagocytosis.

  1989cited by this paper
• Reconstitution of tubular myelin from synthetic lipids and proteins associated with pig pulmonary surfactant.

  1989cited by this paper
• Pulmonary surfactant apoprotein A structure and modulation of surfactant secretion by rat alveolar type II cells.

  1988cited by this paper
• Immunohistochemical localization of pulmonary surfactant apoproteins in various lung tumors: Special reference to nonmucus producing lung adenocarcinomas

  1988cited by this paper
• Alveolar type II cells express a high-affinity receptor for pulmonary surfactant protein A.

  1988cited by this paper
• Surfactant proteins in the diagnosis of fetal lung maturity. I. Predictive accuracy of the 35 kD protein, the lecithin/sphingomyelin ratio, and phosphatidylglycerol.

  1988cited by this paper
• The major lung surfactant protein, SP 28-36, is a calcium-dependent, carbohydrate-binding protein.

  1987cited by this paper
• Surfactant apoprotein Mr = 26,000-36,000 enhances uptake of liposomes by type II cells.

  1987cited by this paper
• Pulmonary surfactant and its components inhibit secretion of phosphatidylcholine from cultured rat alveolar type II cells.

  1987cited by this paper
• Monoclonal antibodies against human pulmonary surfactant apoproteins: specificity and application in immunoassay.

  1985cited by this paper
• Two-Site “Simultaneous” Immunoassay with Monoclonal Antibodies for the Determination of Surfactant Apoproteins in Human Amniotic Fluid

  1985cited by this paper
• Surface active materials from dog lung. I. Method of isolation.

  1972cited by this paper
• Pulmonary alveolar proteinosis.

  1958cited by this paper

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• Effect of Surfactant Protein B and D Genes Polymorphisms on Frequency and Severity of Acute Bronchiolitis

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• Serum surfactant protein D as a significant biomarker for predicting occurrence, progression, acute exacerbation, and mortality in interstitial lung disease: a systematic review and meta-analysis

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  2018cites this paper
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  2009cites this paper
• [Whole lung lavage - Report of four cases of alveolar proteinosis].

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